Circulation of Toscana Virus in a Sample Population of Corsica, France
Sandfly-borne phleboviruses pathogenic to humans, such as Toscana virus (TOSV) and Sandfly Fever Sicilian virus (SFSV), are endemic in the Mediterranean region. In France, several autochthonous cases of TOSV infection have been described, causing either meningitis or encephalitis. The aim of the pre...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-09-01
|
| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/11/9/817 |
| _version_ | 1818057284975067136 |
|---|---|
| author | Shirley Masse Nazli Ayhan Lisandru Capai Frédéric Bosseur Xavier de Lamballerie Rémi Charrel Alessandra Falchi |
| author_facet | Shirley Masse Nazli Ayhan Lisandru Capai Frédéric Bosseur Xavier de Lamballerie Rémi Charrel Alessandra Falchi |
| author_sort | Shirley Masse |
| collection | DOAJ |
| description | Sandfly-borne phleboviruses pathogenic to humans, such as Toscana virus (TOSV) and Sandfly Fever Sicilian virus (SFSV), are endemic in the Mediterranean region. In France, several autochthonous cases of TOSV infection have been described, causing either meningitis or encephalitis. The aim of the present study was to investigate the seroprevalence of TOSV and SFSV antibodies in a healthy population from Corsica. In this cross-sectional study, participants were enrolled (i) from a medical staff at the University of Corsica and (ii) from general practitioners of the Corsican Sentinelles Network. The seroprevalence study was based on a virus microneutralization assay. A total of 240 sera were tested. Altogether, 54 sera (22.5%) were confirmed positive for TOSV antibodies, whereas none were positive for SFSV (0/240). The residential district of participants was significantly associated with TOSV seropositivity (<i>p</i> value = 0.005). The rate of the seropositivity against TOSV in our study suggests that the Corsican population is well exposed to the TOSV. These results encourage the implementation of a systematic surveillance system including entomological, microbiological, and medical aspects for the collection of better information on the diseases that are associated with phleboviruses in Corsica and beyond in the regions where these viruses are present. |
| first_indexed | 2024-12-10T12:42:18Z |
| format | Article |
| id | doaj.art-65300617e09d4c6fbf99cfe35df02c44 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-10T12:42:18Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-65300617e09d4c6fbf99cfe35df02c442022-12-22T01:48:30ZengMDPI AGViruses1999-49152019-09-0111981710.3390/v11090817v11090817Circulation of Toscana Virus in a Sample Population of Corsica, FranceShirley Masse0Nazli Ayhan1Lisandru Capai2Frédéric Bosseur3Xavier de Lamballerie4Rémi Charrel5Alessandra Falchi6Université de Corse Pascal Paoli, EA7310 BIOSCOPE, 20250 Corte, FranceUnité des Virus Emergents (UVE: Aix Marseille Univ, IRD 190, INSERM 1207, IHU Méditerranée Infection), 13385 Marseille, FranceUniversité de Corse Pascal Paoli, EA7310 BIOSCOPE, 20250 Corte, FranceSciences Pour l’Environnement—UMR CNRS 6134, Université de Corse, 20250 Corte, FranceUnité des Virus Emergents (UVE: Aix Marseille Univ, IRD 190, INSERM 1207, IHU Méditerranée Infection), 13385 Marseille, FranceUnité des Virus Emergents (UVE: Aix Marseille Univ, IRD 190, INSERM 1207, IHU Méditerranée Infection), 13385 Marseille, FranceUniversité de Corse Pascal Paoli, EA7310 BIOSCOPE, 20250 Corte, FranceSandfly-borne phleboviruses pathogenic to humans, such as Toscana virus (TOSV) and Sandfly Fever Sicilian virus (SFSV), are endemic in the Mediterranean region. In France, several autochthonous cases of TOSV infection have been described, causing either meningitis or encephalitis. The aim of the present study was to investigate the seroprevalence of TOSV and SFSV antibodies in a healthy population from Corsica. In this cross-sectional study, participants were enrolled (i) from a medical staff at the University of Corsica and (ii) from general practitioners of the Corsican Sentinelles Network. The seroprevalence study was based on a virus microneutralization assay. A total of 240 sera were tested. Altogether, 54 sera (22.5%) were confirmed positive for TOSV antibodies, whereas none were positive for SFSV (0/240). The residential district of participants was significantly associated with TOSV seropositivity (<i>p</i> value = 0.005). The rate of the seropositivity against TOSV in our study suggests that the Corsican population is well exposed to the TOSV. These results encourage the implementation of a systematic surveillance system including entomological, microbiological, and medical aspects for the collection of better information on the diseases that are associated with phleboviruses in Corsica and beyond in the regions where these viruses are present.https://www.mdpi.com/1999-4915/11/9/817Sandfly Fever Sicilian virusseroprevalencemicroneutralizationmeningitisarbovirusarthropod-borne virus<i>Phlebovirus</i><i>Phenuiviridae</i><i>Bunyavirales</i>sandfly |
| spellingShingle | Shirley Masse Nazli Ayhan Lisandru Capai Frédéric Bosseur Xavier de Lamballerie Rémi Charrel Alessandra Falchi Circulation of Toscana Virus in a Sample Population of Corsica, France Viruses Sandfly Fever Sicilian virus seroprevalence microneutralization meningitis arbovirus arthropod-borne virus <i>Phlebovirus</i> <i>Phenuiviridae</i> <i>Bunyavirales</i> sandfly |
| title | Circulation of Toscana Virus in a Sample Population of Corsica, France |
| title_full | Circulation of Toscana Virus in a Sample Population of Corsica, France |
| title_fullStr | Circulation of Toscana Virus in a Sample Population of Corsica, France |
| title_full_unstemmed | Circulation of Toscana Virus in a Sample Population of Corsica, France |
| title_short | Circulation of Toscana Virus in a Sample Population of Corsica, France |
| title_sort | circulation of toscana virus in a sample population of corsica france |
| topic | Sandfly Fever Sicilian virus seroprevalence microneutralization meningitis arbovirus arthropod-borne virus <i>Phlebovirus</i> <i>Phenuiviridae</i> <i>Bunyavirales</i> sandfly |
| url | https://www.mdpi.com/1999-4915/11/9/817 |
| work_keys_str_mv | AT shirleymasse circulationoftoscanavirusinasamplepopulationofcorsicafrance AT nazliayhan circulationoftoscanavirusinasamplepopulationofcorsicafrance AT lisandrucapai circulationoftoscanavirusinasamplepopulationofcorsicafrance AT fredericbosseur circulationoftoscanavirusinasamplepopulationofcorsicafrance AT xavierdelamballerie circulationoftoscanavirusinasamplepopulationofcorsicafrance AT remicharrel circulationoftoscanavirusinasamplepopulationofcorsicafrance AT alessandrafalchi circulationoftoscanavirusinasamplepopulationofcorsicafrance |