Clinical Trial Design in Alzheimer's Disease
Our understanding of Alzheimer's disease (AD) has drastically improved during the past decade as multiple large-scale studies have been implemented. These studies try to provide a large data set of markers and characteristics of patients with AD. The complexity of these factors and the disease...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Research Center for Rational Use of Drugs (RCRUD)
2022-06-01
|
| Series: | Journal of Pharmaceutical Care |
| Subjects: | |
| Online Access: | https://jpc.tums.ac.ir/index.php/jpc/article/view/504 |
| _version_ | 1811288067414163456 |
|---|---|
| author | Seyed Mehrdad Savar Niayesh Mohebbi |
| author_facet | Seyed Mehrdad Savar Niayesh Mohebbi |
| author_sort | Seyed Mehrdad Savar |
| collection | DOAJ |
| description |
Our understanding of Alzheimer's disease (AD) has drastically improved during the past decade as multiple large-scale studies have been implemented. These studies try to provide a large data set of markers and characteristics of patients with AD. The complexity of these factors and the disease itself have hindered the introduction of novel therapeutic strategies for patients with AD and the success rate of clinical trials in AD is significantly low.
We propose the idea of implementing future clinical trials in AD in a more specified population of AD patients based on the mechanism of action of the drug candidate, stage of the disease, and markers involved in the pathogenesis and severity of the disease. The derived results of such trials will not have the problems of doing a post hoc analysis, and although it may harm the generalizability of the results, we may find novel and effective treatment approaches for AD patients with similar characteristics.
|
| first_indexed | 2024-04-13T03:29:30Z |
| format | Article |
| id | doaj.art-65303da28eb4492aa0188718a621ea87 |
| institution | Directory Open Access Journal |
| issn | 2322-4630 2322-4509 |
| language | English |
| last_indexed | 2024-04-13T03:29:30Z |
| publishDate | 2022-06-01 |
| publisher | Research Center for Rational Use of Drugs (RCRUD) |
| record_format | Article |
| series | Journal of Pharmaceutical Care |
| spelling | doaj.art-65303da28eb4492aa0188718a621ea872022-12-22T03:04:32ZengResearch Center for Rational Use of Drugs (RCRUD)Journal of Pharmaceutical Care2322-46302322-45092022-06-0110210.18502/jpc.v10i2.9971Clinical Trial Design in Alzheimer's DiseaseSeyed Mehrdad Savar0Niayesh Mohebbi1Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran.Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran AND Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Our understanding of Alzheimer's disease (AD) has drastically improved during the past decade as multiple large-scale studies have been implemented. These studies try to provide a large data set of markers and characteristics of patients with AD. The complexity of these factors and the disease itself have hindered the introduction of novel therapeutic strategies for patients with AD and the success rate of clinical trials in AD is significantly low. We propose the idea of implementing future clinical trials in AD in a more specified population of AD patients based on the mechanism of action of the drug candidate, stage of the disease, and markers involved in the pathogenesis and severity of the disease. The derived results of such trials will not have the problems of doing a post hoc analysis, and although it may harm the generalizability of the results, we may find novel and effective treatment approaches for AD patients with similar characteristics. https://jpc.tums.ac.ir/index.php/jpc/article/view/504Alzheimer's DiseaseClinical Trial Design |
| spellingShingle | Seyed Mehrdad Savar Niayesh Mohebbi Clinical Trial Design in Alzheimer's Disease Journal of Pharmaceutical Care Alzheimer's Disease Clinical Trial Design |
| title | Clinical Trial Design in Alzheimer's Disease |
| title_full | Clinical Trial Design in Alzheimer's Disease |
| title_fullStr | Clinical Trial Design in Alzheimer's Disease |
| title_full_unstemmed | Clinical Trial Design in Alzheimer's Disease |
| title_short | Clinical Trial Design in Alzheimer's Disease |
| title_sort | clinical trial design in alzheimer s disease |
| topic | Alzheimer's Disease Clinical Trial Design |
| url | https://jpc.tums.ac.ir/index.php/jpc/article/view/504 |
| work_keys_str_mv | AT seyedmehrdadsavar clinicaltrialdesigninalzheimersdisease AT niayeshmohebbi clinicaltrialdesigninalzheimersdisease |