Direct Modification of Extracellular Vesicles and Its Applications for Cancer Therapy: A Mini-Review
Extracellular vesicles (EVs) are a class of lipid membrane-bound vesicles released by various cells and mediate cell-to-cell communication. By reason of their high physiochemical stability and biocompatibility, EVs are considered as novel drug delivery system. An increasing number of studies have in...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2022.910341/full |
| _version_ | 1811307749998329856 |
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| author | Wenbin Nan Wenbin Nan Chao Zhang Hao Wang Hongli Chen Hongli Chen Shenglu Ji |
| author_facet | Wenbin Nan Wenbin Nan Chao Zhang Hao Wang Hongli Chen Hongli Chen Shenglu Ji |
| author_sort | Wenbin Nan |
| collection | DOAJ |
| description | Extracellular vesicles (EVs) are a class of lipid membrane-bound vesicles released by various cells and mediate cell-to-cell communication. By reason of their high physiochemical stability and biocompatibility, EVs are considered as novel drug delivery system. An increasing number of studies have indicated that EVs can be modified to enhance their loading efficiency, targeting ability and therapeutic capabilities for cancer therapy. Compared with the tedious process of gene engineering approaches, direct modification of EVs is easier, faster and versatile. This mini review will summarize the prevailing approaches for direct modification of EVs. Additionally, the potential applications of modified EVs in cancer therapy are also discussed, which will help readers gain a better understanding of the technologies and applications in this field. |
| first_indexed | 2024-04-13T09:09:53Z |
| format | Article |
| id | doaj.art-6530ab6de7164b969c437485ed199d4f |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-04-13T09:09:53Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-6530ab6de7164b969c437485ed199d4f2022-12-22T02:52:54ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462022-05-011010.3389/fchem.2022.910341910341Direct Modification of Extracellular Vesicles and Its Applications for Cancer Therapy: A Mini-ReviewWenbin Nan0Wenbin Nan1Chao Zhang2Hao Wang3Hongli Chen4Hongli Chen5Shenglu Ji6College of Life Science and Technology, Nano Biomedical Materials Research Center, Xinxiang Medical University, Xinxiang, ChinaThe Third Hospital of Xinxiang Medical University, Xinxiang, ChinaCollege of Life Science and Technology, Nano Biomedical Materials Research Center, Xinxiang Medical University, Xinxiang, ChinaCollege of Life Science and Technology, Nano Biomedical Materials Research Center, Xinxiang Medical University, Xinxiang, ChinaCollege of Life Science and Technology, Nano Biomedical Materials Research Center, Xinxiang Medical University, Xinxiang, ChinaThe Third Hospital of Xinxiang Medical University, Xinxiang, ChinaCollege of Life Science and Technology, Nano Biomedical Materials Research Center, Xinxiang Medical University, Xinxiang, ChinaExtracellular vesicles (EVs) are a class of lipid membrane-bound vesicles released by various cells and mediate cell-to-cell communication. By reason of their high physiochemical stability and biocompatibility, EVs are considered as novel drug delivery system. An increasing number of studies have indicated that EVs can be modified to enhance their loading efficiency, targeting ability and therapeutic capabilities for cancer therapy. Compared with the tedious process of gene engineering approaches, direct modification of EVs is easier, faster and versatile. This mini review will summarize the prevailing approaches for direct modification of EVs. Additionally, the potential applications of modified EVs in cancer therapy are also discussed, which will help readers gain a better understanding of the technologies and applications in this field.https://www.frontiersin.org/articles/10.3389/fchem.2022.910341/fullextracellular vesiclescancer therapydrug deliverymodificationnanomedicine |
| spellingShingle | Wenbin Nan Wenbin Nan Chao Zhang Hao Wang Hongli Chen Hongli Chen Shenglu Ji Direct Modification of Extracellular Vesicles and Its Applications for Cancer Therapy: A Mini-Review Frontiers in Chemistry extracellular vesicles cancer therapy drug delivery modification nanomedicine |
| title | Direct Modification of Extracellular Vesicles and Its Applications for Cancer Therapy: A Mini-Review |
| title_full | Direct Modification of Extracellular Vesicles and Its Applications for Cancer Therapy: A Mini-Review |
| title_fullStr | Direct Modification of Extracellular Vesicles and Its Applications for Cancer Therapy: A Mini-Review |
| title_full_unstemmed | Direct Modification of Extracellular Vesicles and Its Applications for Cancer Therapy: A Mini-Review |
| title_short | Direct Modification of Extracellular Vesicles and Its Applications for Cancer Therapy: A Mini-Review |
| title_sort | direct modification of extracellular vesicles and its applications for cancer therapy a mini review |
| topic | extracellular vesicles cancer therapy drug delivery modification nanomedicine |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2022.910341/full |
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