Presurgical language mapping in epilepsy: Using fMRI of reading to identify functional reorganization in a patient with long-standing temporal lobe epilepsy

We report a 55-year-old, right-handed patient with intractable left temporal lobe epilepsy, who previously had a partial left temporal lobectomy. The patient could talk during seizures, suggesting that he might have language dominance in the right hemisphere. Presurgical fMRI localization of languag...

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Main Authors: Layla Gould, Marla J.S. Mickleborough, Adam Wu, Jose Tellez, Chelsea Ekstrand, Eric Lorentz, Tasha Ellchuk, Paul Babyn, Ron Borowsky
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Epilepsy and Behavior Case Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2213323215000432
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author Layla Gould
Marla J.S. Mickleborough
Adam Wu
Jose Tellez
Chelsea Ekstrand
Eric Lorentz
Tasha Ellchuk
Paul Babyn
Ron Borowsky
author_facet Layla Gould
Marla J.S. Mickleborough
Adam Wu
Jose Tellez
Chelsea Ekstrand
Eric Lorentz
Tasha Ellchuk
Paul Babyn
Ron Borowsky
author_sort Layla Gould
collection DOAJ
description We report a 55-year-old, right-handed patient with intractable left temporal lobe epilepsy, who previously had a partial left temporal lobectomy. The patient could talk during seizures, suggesting that he might have language dominance in the right hemisphere. Presurgical fMRI localization of language processing including reading of exception and regular words, pseudohomophones, and dual meaning words confirmed the clinical hypothesis of right language dominance, with only small amounts of activation near the planned surgical resection and, thus, minimal eloquent cortex to avoid during surgery. Postoperatively, the patient was rendered seizure-free without speech deficits.
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spelling doaj.art-6530feef2adb440e89b42a05f22091ab2022-12-21T17:45:46ZengElsevierEpilepsy and Behavior Case Reports2213-32322016-01-015C61010.1016/j.ebcr.2015.10.003Presurgical language mapping in epilepsy: Using fMRI of reading to identify functional reorganization in a patient with long-standing temporal lobe epilepsyLayla Gould0Marla J.S. Mickleborough1Adam Wu2Jose Tellez3Chelsea Ekstrand4Eric Lorentz5Tasha Ellchuk6Paul Babyn7Ron Borowsky8Department of Psychology, 9 Campus Drive, University of Saskatchewan, Saskatoon, SK S7N 5A5, CanadaDepartment of Psychology, 9 Campus Drive, University of Saskatchewan, Saskatoon, SK S7N 5A5, CanadaDepartment of Surgery, Division of Neurosurgery, Royal University Hospital, 103 Hospital Drive, Saskatoon, SK S7N OW8, CanadaDepartment of Neurology, Royal University Hospital, 103 Hospital Drive, Saskatoon, SK S7N OW8, CanadaDepartment of Psychology, 9 Campus Drive, University of Saskatchewan, Saskatoon, SK S7N 5A5, CanadaDepartment of Psychology, 9 Campus Drive, University of Saskatchewan, Saskatoon, SK S7N 5A5, CanadaDepartment of Medical Imaging, Royal University Hospital, 103 Hospital Drive, Saskatoon, SK S7N 0W8, CanadaDepartment of Medical Imaging, Royal University Hospital, 103 Hospital Drive, Saskatoon, SK S7N 0W8, CanadaDepartment of Psychology, 9 Campus Drive, University of Saskatchewan, Saskatoon, SK S7N 5A5, CanadaWe report a 55-year-old, right-handed patient with intractable left temporal lobe epilepsy, who previously had a partial left temporal lobectomy. The patient could talk during seizures, suggesting that he might have language dominance in the right hemisphere. Presurgical fMRI localization of language processing including reading of exception and regular words, pseudohomophones, and dual meaning words confirmed the clinical hypothesis of right language dominance, with only small amounts of activation near the planned surgical resection and, thus, minimal eloquent cortex to avoid during surgery. Postoperatively, the patient was rendered seizure-free without speech deficits.http://www.sciencedirect.com/science/article/pii/S2213323215000432LanguageTemporal lobe epilepsyfMRINeurosurgeryReading
spellingShingle Layla Gould
Marla J.S. Mickleborough
Adam Wu
Jose Tellez
Chelsea Ekstrand
Eric Lorentz
Tasha Ellchuk
Paul Babyn
Ron Borowsky
Presurgical language mapping in epilepsy: Using fMRI of reading to identify functional reorganization in a patient with long-standing temporal lobe epilepsy
Epilepsy and Behavior Case Reports
Language
Temporal lobe epilepsy
fMRI
Neurosurgery
Reading
title Presurgical language mapping in epilepsy: Using fMRI of reading to identify functional reorganization in a patient with long-standing temporal lobe epilepsy
title_full Presurgical language mapping in epilepsy: Using fMRI of reading to identify functional reorganization in a patient with long-standing temporal lobe epilepsy
title_fullStr Presurgical language mapping in epilepsy: Using fMRI of reading to identify functional reorganization in a patient with long-standing temporal lobe epilepsy
title_full_unstemmed Presurgical language mapping in epilepsy: Using fMRI of reading to identify functional reorganization in a patient with long-standing temporal lobe epilepsy
title_short Presurgical language mapping in epilepsy: Using fMRI of reading to identify functional reorganization in a patient with long-standing temporal lobe epilepsy
title_sort presurgical language mapping in epilepsy using fmri of reading to identify functional reorganization in a patient with long standing temporal lobe epilepsy
topic Language
Temporal lobe epilepsy
fMRI
Neurosurgery
Reading
url http://www.sciencedirect.com/science/article/pii/S2213323215000432
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