ER and vacuoles: never been closer
The endoplasmic reticulum (ER) represents the gateway for intracellular trafficking of membrane proteins, soluble cargoes and lipids. In all eukaryotes, the best described mechanism of exiting the ER is via COPII-coated vesicles, which transport both membrane proteins and soluble cargo to the cis-Go...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-02-01
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| Series: | Frontiers in Plant Science |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fpls.2014.00020/full |
| _version_ | 1818862513486299136 |
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| author | Corrado eViotti |
| author_facet | Corrado eViotti |
| author_sort | Corrado eViotti |
| collection | DOAJ |
| description | The endoplasmic reticulum (ER) represents the gateway for intracellular trafficking of membrane proteins, soluble cargoes and lipids. In all eukaryotes, the best described mechanism of exiting the ER is via COPII-coated vesicles, which transport both membrane proteins and soluble cargo to the cis-Golgi. The vacuole, together with the plasma membrane, is the most distal point of the secretory pathway, and many vacuolar proteins are transported from the ER through intermediate compartments. However, past results and recent findings demonstrate the presence of alternative transport routes from the ER towards the tonoplast, which are independent of Golgi- and post-Golgi trafficking. Moreover, the transport mechanism of the vacuolar proton pumps VHA-a3 and AVP1 challenges the current model of vacuole biogenesis, pointing to the endoplasmic reticulum for being the main membrane source for the biogenesis of the plant lytic compartment. This review gives an overview of the current knowledge on the transport routes towards the vacuole and discusses the possible mechanism of vacuole biogenesis in plants. |
| first_indexed | 2024-12-19T10:01:04Z |
| format | Article |
| id | doaj.art-653141253a264b45bec84f39f74c21a5 |
| institution | Directory Open Access Journal |
| issn | 1664-462X |
| language | English |
| last_indexed | 2024-12-19T10:01:04Z |
| publishDate | 2014-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Plant Science |
| spelling | doaj.art-653141253a264b45bec84f39f74c21a52022-12-21T20:26:39ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2014-02-01510.3389/fpls.2014.0002078799ER and vacuoles: never been closerCorrado eViotti0Umeå UniversityThe endoplasmic reticulum (ER) represents the gateway for intracellular trafficking of membrane proteins, soluble cargoes and lipids. In all eukaryotes, the best described mechanism of exiting the ER is via COPII-coated vesicles, which transport both membrane proteins and soluble cargo to the cis-Golgi. The vacuole, together with the plasma membrane, is the most distal point of the secretory pathway, and many vacuolar proteins are transported from the ER through intermediate compartments. However, past results and recent findings demonstrate the presence of alternative transport routes from the ER towards the tonoplast, which are independent of Golgi- and post-Golgi trafficking. Moreover, the transport mechanism of the vacuolar proton pumps VHA-a3 and AVP1 challenges the current model of vacuole biogenesis, pointing to the endoplasmic reticulum for being the main membrane source for the biogenesis of the plant lytic compartment. This review gives an overview of the current knowledge on the transport routes towards the vacuole and discusses the possible mechanism of vacuole biogenesis in plants.http://journal.frontiersin.org/Journal/10.3389/fpls.2014.00020/fullEndoplasmic ReticulumGolgi ApparatusMultivesicular Bodiestrans-Golgi Networkvacuolemultivesicular body |
| spellingShingle | Corrado eViotti ER and vacuoles: never been closer Frontiers in Plant Science Endoplasmic Reticulum Golgi Apparatus Multivesicular Bodies trans-Golgi Network vacuole multivesicular body |
| title | ER and vacuoles: never been closer |
| title_full | ER and vacuoles: never been closer |
| title_fullStr | ER and vacuoles: never been closer |
| title_full_unstemmed | ER and vacuoles: never been closer |
| title_short | ER and vacuoles: never been closer |
| title_sort | er and vacuoles never been closer |
| topic | Endoplasmic Reticulum Golgi Apparatus Multivesicular Bodies trans-Golgi Network vacuole multivesicular body |
| url | http://journal.frontiersin.org/Journal/10.3389/fpls.2014.00020/full |
| work_keys_str_mv | AT corradoeviotti erandvacuolesneverbeencloser |