Design of a new series of potent and selective beta-3 adrenergic receptor (β3-AdrR) antagonists for the treatment of acute decompensated heart failure

Design of a new series of potent and selective beta-3 adrenergic receptor (β3-AdrR) antagonists for the treatment of acute decompensated heart failure

The design of a new series of β3-Adrenergic receptor (β3-AdrR) antagonists is described. The use of a spiro building block in the core of the molecule provided novel compounds with reduced aromaticity and antagonist activity at the human β3-AdrR. A shortening of this core and exploration of a series...

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Bibliographic Details
Main Authors: Thuy-Anh Tran, Bryan Kramer, Young-Jun Shin, Quyen-Quyen Do, Brett Ullman, Vasudeva Sagi, John W. Adams, Yunqing Shi, Hsin-Hui Shu, David J. Unett, Joel Gatlin, Michael E. Morgan, Jaimie Reuter, Anthony Blackburn, Carleton R. Sage, Graeme Semple
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Results in Chemistry
Subjects:
GPCR
β3-Adrenergic receptor
β3-AdrR
Antagonist
Acute decompensated heart failure
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715622002375

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