QM/MM Studies of Contemporary and Novel Membrane Raft Fluorescent Probes
We have studied a number of contemporary and novel membrane probes, selected for their structural similarity to membrane raft components, in order to properly anchor themselves within a sphingolipid/cholesterol rich region. A QM/MM approach was adopted in order to understand the structural and elect...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-07-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/19/7/10230 |
| _version_ | 1818276849291100160 |
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| author | Hannah L. Blake David Robinson |
| author_facet | Hannah L. Blake David Robinson |
| author_sort | Hannah L. Blake |
| collection | DOAJ |
| description | We have studied a number of contemporary and novel membrane probes, selected for their structural similarity to membrane raft components, in order to properly anchor themselves within a sphingolipid/cholesterol rich region. A QM/MM approach was adopted in order to understand the structural and electrostatic influences of fluorescence emission shifts of the probes in different lipid and solvation environments. The proposed modifications to the membrane probes have shown encouraging data relating not only to emission shifts within the membrane, but also their ability to anchor within a membrane raft domain and the stability to internalization within a membrane system. |
| first_indexed | 2024-12-12T22:52:11Z |
| format | Article |
| id | doaj.art-653486e2b3354eb6ac3de26cea610641 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-12T22:52:11Z |
| publishDate | 2014-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-653486e2b3354eb6ac3de26cea6106412022-12-22T00:09:01ZengMDPI AGMolecules1420-30492014-07-01197102301024110.3390/molecules190710230molecules190710230QM/MM Studies of Contemporary and Novel Membrane Raft Fluorescent ProbesHannah L. Blake0David Robinson1School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UKSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UKWe have studied a number of contemporary and novel membrane probes, selected for their structural similarity to membrane raft components, in order to properly anchor themselves within a sphingolipid/cholesterol rich region. A QM/MM approach was adopted in order to understand the structural and electrostatic influences of fluorescence emission shifts of the probes in different lipid and solvation environments. The proposed modifications to the membrane probes have shown encouraging data relating not only to emission shifts within the membrane, but also their ability to anchor within a membrane raft domain and the stability to internalization within a membrane system.http://www.mdpi.com/1420-3049/19/7/10230QM/MMfluorescencemembrane probesTDDFTlipid raft |
| spellingShingle | Hannah L. Blake David Robinson QM/MM Studies of Contemporary and Novel Membrane Raft Fluorescent Probes Molecules QM/MM fluorescence membrane probes TDDFT lipid raft |
| title | QM/MM Studies of Contemporary and Novel Membrane Raft Fluorescent Probes |
| title_full | QM/MM Studies of Contemporary and Novel Membrane Raft Fluorescent Probes |
| title_fullStr | QM/MM Studies of Contemporary and Novel Membrane Raft Fluorescent Probes |
| title_full_unstemmed | QM/MM Studies of Contemporary and Novel Membrane Raft Fluorescent Probes |
| title_short | QM/MM Studies of Contemporary and Novel Membrane Raft Fluorescent Probes |
| title_sort | qm mm studies of contemporary and novel membrane raft fluorescent probes |
| topic | QM/MM fluorescence membrane probes TDDFT lipid raft |
| url | http://www.mdpi.com/1420-3049/19/7/10230 |
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