Implementing Curcumin in Translational Oncology Research
Most data published on curcumin and curcumin-based formulations are very promising. In cancer research, the majority of data has been obtained in vitro. Less frequently, researchers used experimental animals. The results of several clinical studies are conclusive, and these studies have established...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/25/22/5240 |
| _version_ | 1797548267179868160 |
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| author | Koraljka Gall Trošelj Ivana Samaržija Marko Tomljanović Renata Novak Kujundžić Nikola Đaković Anamarija Mojzeš |
| author_facet | Koraljka Gall Trošelj Ivana Samaržija Marko Tomljanović Renata Novak Kujundžić Nikola Đaković Anamarija Mojzeš |
| author_sort | Koraljka Gall Trošelj |
| collection | DOAJ |
| description | Most data published on curcumin and curcumin-based formulations are very promising. In cancer research, the majority of data has been obtained in vitro. Less frequently, researchers used experimental animals. The results of several clinical studies are conclusive, and these studies have established a good foundation for further research focusing on implementing curcumin in clinical oncology. However, the issues regarding timely data reporting and lack of disclosure of the exact curcumin formulations used in these studies should not be neglected. This article is a snapshot of the current status of publicly available data on curcumin clinical trials and a detailed presentation of results obtained so far with some curcumin formulations. Phenomena related to the observed effects of curcumin shown in clinical trials are presented, and its modifying effect on gut microbiota and metabolic reprogramming is discussed. Based on available data, there is a strong indication that curcumin and its metabolites present molecules that do not necessarily need to be abundant in order to act locally and benefit systemically. Future clinical studies should be designed in a way that will take that fact into consideration. |
| first_indexed | 2024-03-10T14:56:53Z |
| format | Article |
| id | doaj.art-6534d3a6975142dcae329548afe220d6 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T14:56:53Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-6534d3a6975142dcae329548afe220d62023-11-20T20:29:32ZengMDPI AGMolecules1420-30492020-11-012522524010.3390/molecules25225240Implementing Curcumin in Translational Oncology ResearchKoraljka Gall Trošelj0Ivana Samaržija1Marko Tomljanović2Renata Novak Kujundžić3Nikola Đaković4Anamarija Mojzeš5Laboratory for Epigenomics, Ruđer Bošković Institute, Division of Molecular Medicine, 10000 Zagreb, CroatiaLaboratory for Epigenomics, Ruđer Bošković Institute, Division of Molecular Medicine, 10000 Zagreb, CroatiaLaboratory for Epigenomics, Ruđer Bošković Institute, Division of Molecular Medicine, 10000 Zagreb, CroatiaLaboratory for Epigenomics, Ruđer Bošković Institute, Division of Molecular Medicine, 10000 Zagreb, CroatiaInstitute for Clinical Medical Research and Education, University Hospital Centre Sisters of Charity, 10000 Zagreb, CroatiaLaboratory for Epigenomics, Ruđer Bošković Institute, Division of Molecular Medicine, 10000 Zagreb, CroatiaMost data published on curcumin and curcumin-based formulations are very promising. In cancer research, the majority of data has been obtained in vitro. Less frequently, researchers used experimental animals. The results of several clinical studies are conclusive, and these studies have established a good foundation for further research focusing on implementing curcumin in clinical oncology. However, the issues regarding timely data reporting and lack of disclosure of the exact curcumin formulations used in these studies should not be neglected. This article is a snapshot of the current status of publicly available data on curcumin clinical trials and a detailed presentation of results obtained so far with some curcumin formulations. Phenomena related to the observed effects of curcumin shown in clinical trials are presented, and its modifying effect on gut microbiota and metabolic reprogramming is discussed. Based on available data, there is a strong indication that curcumin and its metabolites present molecules that do not necessarily need to be abundant in order to act locally and benefit systemically. Future clinical studies should be designed in a way that will take that fact into consideration.https://www.mdpi.com/1420-3049/25/22/5240cancer therapyclinical trialsmicrobiotaIL-17nicotinamide <i>N</i>-methyltransferasemetabolic reprogramming |
| spellingShingle | Koraljka Gall Trošelj Ivana Samaržija Marko Tomljanović Renata Novak Kujundžić Nikola Đaković Anamarija Mojzeš Implementing Curcumin in Translational Oncology Research Molecules cancer therapy clinical trials microbiota IL-17 nicotinamide <i>N</i>-methyltransferase metabolic reprogramming |
| title | Implementing Curcumin in Translational Oncology Research |
| title_full | Implementing Curcumin in Translational Oncology Research |
| title_fullStr | Implementing Curcumin in Translational Oncology Research |
| title_full_unstemmed | Implementing Curcumin in Translational Oncology Research |
| title_short | Implementing Curcumin in Translational Oncology Research |
| title_sort | implementing curcumin in translational oncology research |
| topic | cancer therapy clinical trials microbiota IL-17 nicotinamide <i>N</i>-methyltransferase metabolic reprogramming |
| url | https://www.mdpi.com/1420-3049/25/22/5240 |
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