DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis

DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis

Pancreatic ductal adenocarcinoma (PDAC) tumors are characterized by a desmoplastic reaction resulting in dense deposition of collagen that is known to promote cancer progression. A central mediator of protumorigenic collagen signaling is the receptor tyrosine kinase discoid domain receptor 1 (DDR1)....

Full description

Bibliographic Details
Main Authors: Jenying Deng, Yaan Kang, Chien-Chia Cheng, Xinqun Li, Bingbing Dai, Matthew H. Katz, Taoyan Men, Michael P. Kim, Eugene A. Koay, Huocong Huang, Rolf A. Brekken, Jason B. Fleming
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-09-01
Series:JCI Insight
Subjects:
Oncology
Online Access:https://doi.org/10.1172/jci.insight.146133

Internet

https://doi.org/10.1172/jci.insight.146133

Similar Items