Altered gut microbiomes are associated with the symptomatic status of unruptured intracranial aneurysms
BackgroundGut microbiome has recently been recognized as an important environmental factor affecting the occurrence and development of unruptured intracranial aneurysms (UIA). This study aimed to investigate the relationship between gut microbiome and symptomatic UIA, which is a predictor of instabi...
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.1056785/full |
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| author | Kaijian Sun Ying Cao Yiting Chen Qing Peng Yugu Xie Yunhao Luo Hao Tian Xin Li Meiqin Zeng Xin Zhang Xifeng Li Shixing Su Xuying He Chuanzhi Duan Haitao Sun Haitao Sun Haitao Sun |
| author_facet | Kaijian Sun Ying Cao Yiting Chen Qing Peng Yugu Xie Yunhao Luo Hao Tian Xin Li Meiqin Zeng Xin Zhang Xifeng Li Shixing Su Xuying He Chuanzhi Duan Haitao Sun Haitao Sun Haitao Sun |
| author_sort | Kaijian Sun |
| collection | DOAJ |
| description | BackgroundGut microbiome has recently been recognized as an important environmental factor affecting the occurrence and development of unruptured intracranial aneurysms (UIA). This study aimed to investigate the relationship between gut microbiome and symptomatic UIA, which is a predictor of instability and a high propensity to rupture.MethodsA total of 132 patients including 86 asymptomatic UIA and 46 symptomatic UIA were recruited in the study. The composition of gut bacterial communities was determined by 16S ribosomal RNA gene sequencing. In addition, Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) was used to predict the functional composition of the gut microbiome.ResultsThere is no difference in the fecal microbial alpha diversity between symptomatic and asymptomatic UIA, but gut microbiome composition changed significantly. At the order level, the relative abundance of Clostridiales was significantly enriched in the symptomatic compared with asymptomatic UIA (p = 0.043). In addition, similar alterations were observed at the family levels of Ruminococcaceae. The Linear discriminant analysis (LEfSe) revealed Fournierella, Ruthenibacterium, and Anaerotruncus as discriminative features in the symptomatic group. Notably, functional differences in gut microbiome of patients with symptomatic UIA included decreased propionate metabolism pathway and enrichment of peptidoglycan biosynthesis pathways.ConclusionThe present study comprehensively characterizes gut microbiome in a large cohort of different risk statuses of UIA patients and demonstrates the potential biological function of gut microbiome involved in the development of UIA. It may provide additional benefits in guiding UIA management and improving patient outcomes. |
| first_indexed | 2024-04-11T05:36:56Z |
| format | Article |
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| language | English |
| last_indexed | 2024-04-11T05:36:56Z |
| publishDate | 2022-12-01 |
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| series | Frontiers in Neuroscience |
| spelling | doaj.art-65375cb37bbb4423920a758272781dd22022-12-22T10:49:11ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-12-011610.3389/fnins.2022.10567851056785Altered gut microbiomes are associated with the symptomatic status of unruptured intracranial aneurysmsKaijian Sun0Ying Cao1Yiting Chen2Qing Peng3Yugu Xie4Yunhao Luo5Hao Tian6Xin Li7Meiqin Zeng8Xin Zhang9Xifeng Li10Shixing Su11Xuying He12Chuanzhi Duan13Haitao Sun14Haitao Sun15Haitao Sun16The National Key Clinical Specialty, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Cerebrovascular Surgery, Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Neurosurgery Center, Zhujiang Hospital, The Neurosurgery Institute of Guangdong Province, Southern Medical University, Guangzhou, Guangdong, ChinaThe National Key Clinical Specialty, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Cerebrovascular Surgery, Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Neurosurgery Center, Zhujiang Hospital, The Neurosurgery Institute of Guangdong Province, Southern Medical University, Guangzhou, Guangdong, ChinaThe National Key Clinical Specialty, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Cerebrovascular Surgery, Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Neurosurgery Center, Zhujiang Hospital, The Neurosurgery Institute of Guangdong Province, Southern Medical University, Guangzhou, Guangdong, ChinaThe National Key Clinical Specialty, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Cerebrovascular Surgery, Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Neurosurgery Center, Zhujiang Hospital, The Neurosurgery Institute of Guangdong Province, Southern Medical University, Guangzhou, Guangdong, ChinaDepartment of Laboratory Medicine, Clinical Biobank Centre, Microbiome Medicine Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, ChinaDepartment of Laboratory Medicine, Clinical Biobank Centre, Microbiome Medicine Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, ChinaThe National Key Clinical Specialty, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Cerebrovascular Surgery, Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Neurosurgery Center, Zhujiang Hospital, The Neurosurgery Institute of Guangdong Province, Southern Medical University, Guangzhou, Guangdong, ChinaDepartment of Laboratory Medicine, Clinical Biobank Centre, Microbiome Medicine Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, ChinaThe National Key Clinical Specialty, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Cerebrovascular Surgery, Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Neurosurgery Center, Zhujiang Hospital, The Neurosurgery Institute of Guangdong Province, Southern Medical University, Guangzhou, Guangdong, ChinaThe National Key Clinical Specialty, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Cerebrovascular Surgery, Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Neurosurgery Center, Zhujiang Hospital, The Neurosurgery Institute of Guangdong Province, Southern Medical University, Guangzhou, Guangdong, ChinaThe National Key Clinical Specialty, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Cerebrovascular Surgery, Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Neurosurgery Center, Zhujiang Hospital, The Neurosurgery Institute of Guangdong Province, Southern Medical University, Guangzhou, Guangdong, ChinaThe National Key Clinical Specialty, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Cerebrovascular Surgery, Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Neurosurgery Center, Zhujiang Hospital, The Neurosurgery Institute of Guangdong Province, Southern Medical University, Guangzhou, Guangdong, ChinaThe National Key Clinical Specialty, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Cerebrovascular Surgery, Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Neurosurgery Center, Zhujiang Hospital, The Neurosurgery Institute of Guangdong Province, Southern Medical University, Guangzhou, Guangdong, ChinaThe National Key Clinical Specialty, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Cerebrovascular Surgery, Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Neurosurgery Center, Zhujiang Hospital, The Neurosurgery Institute of Guangdong Province, Southern Medical University, Guangzhou, Guangdong, ChinaThe National Key Clinical Specialty, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Cerebrovascular Surgery, Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Neurosurgery Center, Zhujiang Hospital, The Neurosurgery Institute of Guangdong Province, Southern Medical University, Guangzhou, Guangdong, ChinaDepartment of Laboratory Medicine, Clinical Biobank Centre, Microbiome Medicine Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, ChinaKey Laboratory of Mental Health of the Ministry of Education, Guangdong–Hong Kong–Macao Greater Bay Area Centre for Brain Science and Brain-Inspired Intelligence, Southern Medical University, Guangzhou, Guangdong, ChinaBackgroundGut microbiome has recently been recognized as an important environmental factor affecting the occurrence and development of unruptured intracranial aneurysms (UIA). This study aimed to investigate the relationship between gut microbiome and symptomatic UIA, which is a predictor of instability and a high propensity to rupture.MethodsA total of 132 patients including 86 asymptomatic UIA and 46 symptomatic UIA were recruited in the study. The composition of gut bacterial communities was determined by 16S ribosomal RNA gene sequencing. In addition, Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) was used to predict the functional composition of the gut microbiome.ResultsThere is no difference in the fecal microbial alpha diversity between symptomatic and asymptomatic UIA, but gut microbiome composition changed significantly. At the order level, the relative abundance of Clostridiales was significantly enriched in the symptomatic compared with asymptomatic UIA (p = 0.043). In addition, similar alterations were observed at the family levels of Ruminococcaceae. The Linear discriminant analysis (LEfSe) revealed Fournierella, Ruthenibacterium, and Anaerotruncus as discriminative features in the symptomatic group. Notably, functional differences in gut microbiome of patients with symptomatic UIA included decreased propionate metabolism pathway and enrichment of peptidoglycan biosynthesis pathways.ConclusionThe present study comprehensively characterizes gut microbiome in a large cohort of different risk statuses of UIA patients and demonstrates the potential biological function of gut microbiome involved in the development of UIA. It may provide additional benefits in guiding UIA management and improving patient outcomes.https://www.frontiersin.org/articles/10.3389/fnins.2022.1056785/fullsymptomatic intracranial aneurysmsgut microbiomegut-brain axis16s rDNA sequencing16S rDNA sequence |
| spellingShingle | Kaijian Sun Ying Cao Yiting Chen Qing Peng Yugu Xie Yunhao Luo Hao Tian Xin Li Meiqin Zeng Xin Zhang Xifeng Li Shixing Su Xuying He Chuanzhi Duan Haitao Sun Haitao Sun Haitao Sun Altered gut microbiomes are associated with the symptomatic status of unruptured intracranial aneurysms Frontiers in Neuroscience symptomatic intracranial aneurysms gut microbiome gut-brain axis 16s rDNA sequencing 16S rDNA sequence |
| title | Altered gut microbiomes are associated with the symptomatic status of unruptured intracranial aneurysms |
| title_full | Altered gut microbiomes are associated with the symptomatic status of unruptured intracranial aneurysms |
| title_fullStr | Altered gut microbiomes are associated with the symptomatic status of unruptured intracranial aneurysms |
| title_full_unstemmed | Altered gut microbiomes are associated with the symptomatic status of unruptured intracranial aneurysms |
| title_short | Altered gut microbiomes are associated with the symptomatic status of unruptured intracranial aneurysms |
| title_sort | altered gut microbiomes are associated with the symptomatic status of unruptured intracranial aneurysms |
| topic | symptomatic intracranial aneurysms gut microbiome gut-brain axis 16s rDNA sequencing 16S rDNA sequence |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.1056785/full |
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