Rapid and Sensitive LC-MS/MS Method for the Determination of Metoprolol in Beagle Dog Plasma with a Simple Protein Precipitation Treatment and Its Pharmacokinetic Applications

Rapid and Sensitive LC-MS/MS Method for the Determination of Metoprolol in Beagle Dog Plasma with a Simple Protein Precipitation Treatment and Its Pharmacokinetic Applications

: A rapid LC-MS/MS method with good accuracy and sensitivity was developed and validated for the pharmacokinetics study of metoprolol (MP) in beagle dogs. The plasma samples were simply precipitated by methanol and then analyzed by LC-MS/MS. An Ultimate XB-C18 column (150 × 2.1 mm ID, 5 μm) was used...

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Bibliographic Details
Main Authors: Aihua Hong, Linlin Li, Xiaofei Li, Shaolian Fu, Xiaoqi Zhang, Zhiguo Ma, Kelong Peng, Xingli Wang, Sha Li, Jie Jiang
Format: Article
Language:English
Published: MDPI AG 2012-03-01
Series:Molecules
Subjects:
metoprolol tartrate
LC-MS/MS
pharmacokinetics
protein precipitation method
Online Access:http://www.mdpi.com/1420-3049/17/3/2663/

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