Associations of Vitamin B6 Intake and Plasma Pyridoxal 5′-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003–2004
Previous evidence suggests a potential dual impact of aging and vitamin B6 (B6) deficiency on polyunsaturated fatty acid (PUFA) metabolism; gender may influence PUFA biosynthesis. Perturbation of PUFA compositions during B6 deficiency could be linked to age-related health outcomes. However, little i...
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MDPI AG
2022-06-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/11/2336 |
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| author | Hyojung Kim Evelyn B. Enrione Vijaya Narayanan Tan Li Adriana Campa |
| author_facet | Hyojung Kim Evelyn B. Enrione Vijaya Narayanan Tan Li Adriana Campa |
| author_sort | Hyojung Kim |
| collection | DOAJ |
| description | Previous evidence suggests a potential dual impact of aging and vitamin B6 (B6) deficiency on polyunsaturated fatty acid (PUFA) metabolism; gender may influence PUFA biosynthesis. Perturbation of PUFA compositions during B6 deficiency could be linked to age-related health outcomes. However, little is known about the interrelationships between vitamin B6, PUFA, and gender in the older population. Therefore, we investigated whether gender-specific associations of B6 intake and plasma pyridoxal 5’-phosphate (PLP) concentration, respectively, with plasma PUFA concentrations and ratios (eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), arachidonic acid (AA), EPA + DHA, EPA/AA, and (EPA + DHA)/AA) existed in older adults. We further examined the relationships of adequate B6 status (PLP ≥ 20 nmol/L) with high (above median) plasma PUFA relative to deficient B6 status. This cross-sectional study analyzed 461 participants aged ≥60 years from NHANES 2003–2004. Nutrient intakes were assessed using two 24-h recalls and supplement questionnaires. PLP and PUFA concentrations were measured. Multivariate linear regression assessed the association of B6 intake and PLP with PUFA; multivariate logistic regression evaluated the relationship of adequate B6 status with high plasma PUFA, adjusting for demographic, socioeconomic, and dietary factors; physical activity; smoking; alcohol; medication; and BMI. There were interactions between gender and B6 intake on EPA (<i>P-<sub>interaction</sub></i> = 0.008) and AA (<i>P-<sub>interaction</sub></i> = 0.004) only, whereas no interaction existed between gender and PLP on PUFA. PLP was directly associated with EPA (β = 0.181, <i>P</i> = 0.002), DHA (β = 0.109, <i>P</i> = 0.005), EPA + DHA (β = 0.14, <i>P</i> = 0.002), EPA/AA (β = 0.186, <i>P</i> = 0.004), and (EPA + DHA)/AA (β = 0.13, <i>P</i> = 0.026). The odds of having high plasma EPA (adjusted (a) OR: 2.03, <i>P</i> = 0.049) and EPA/AA (aOR: 3.83, <i>P</i> < 0.0001) were greater in those with adequate B6 status compared to those with deficient B6 status. In conclusion, in US older adults, a higher PLP level was associated with a greater level of EPA, DHA, EPA + DHA, EPA/AA, and (EPA + DHA)/AA. Adequate B6 status was associated with high EPA and EPA/AA status. These findings suggest that sufficient vitamin B6 status may positively influence PUFA metabolism in older adults. |
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| spelling | doaj.art-65387f6f37304dbaaef28d118db61e162023-11-23T14:37:26ZengMDPI AGNutrients2072-66432022-06-011411233610.3390/nu14112336Associations of Vitamin B6 Intake and Plasma Pyridoxal 5′-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003–2004Hyojung Kim0Evelyn B. Enrione1Vijaya Narayanan2Tan Li3Adriana Campa4Department of Dietetics and Nutrition, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL 33199, USADepartment of Dietetics and Nutrition, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL 33199, USADepartment of Dietetics and Nutrition, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL 33199, USADepartment of Biostatistics, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL 33199, USADepartment of Dietetics and Nutrition, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL 33199, USAPrevious evidence suggests a potential dual impact of aging and vitamin B6 (B6) deficiency on polyunsaturated fatty acid (PUFA) metabolism; gender may influence PUFA biosynthesis. Perturbation of PUFA compositions during B6 deficiency could be linked to age-related health outcomes. However, little is known about the interrelationships between vitamin B6, PUFA, and gender in the older population. Therefore, we investigated whether gender-specific associations of B6 intake and plasma pyridoxal 5’-phosphate (PLP) concentration, respectively, with plasma PUFA concentrations and ratios (eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), arachidonic acid (AA), EPA + DHA, EPA/AA, and (EPA + DHA)/AA) existed in older adults. We further examined the relationships of adequate B6 status (PLP ≥ 20 nmol/L) with high (above median) plasma PUFA relative to deficient B6 status. This cross-sectional study analyzed 461 participants aged ≥60 years from NHANES 2003–2004. Nutrient intakes were assessed using two 24-h recalls and supplement questionnaires. PLP and PUFA concentrations were measured. Multivariate linear regression assessed the association of B6 intake and PLP with PUFA; multivariate logistic regression evaluated the relationship of adequate B6 status with high plasma PUFA, adjusting for demographic, socioeconomic, and dietary factors; physical activity; smoking; alcohol; medication; and BMI. There were interactions between gender and B6 intake on EPA (<i>P-<sub>interaction</sub></i> = 0.008) and AA (<i>P-<sub>interaction</sub></i> = 0.004) only, whereas no interaction existed between gender and PLP on PUFA. PLP was directly associated with EPA (β = 0.181, <i>P</i> = 0.002), DHA (β = 0.109, <i>P</i> = 0.005), EPA + DHA (β = 0.14, <i>P</i> = 0.002), EPA/AA (β = 0.186, <i>P</i> = 0.004), and (EPA + DHA)/AA (β = 0.13, <i>P</i> = 0.026). The odds of having high plasma EPA (adjusted (a) OR: 2.03, <i>P</i> = 0.049) and EPA/AA (aOR: 3.83, <i>P</i> < 0.0001) were greater in those with adequate B6 status compared to those with deficient B6 status. In conclusion, in US older adults, a higher PLP level was associated with a greater level of EPA, DHA, EPA + DHA, EPA/AA, and (EPA + DHA)/AA. Adequate B6 status was associated with high EPA and EPA/AA status. These findings suggest that sufficient vitamin B6 status may positively influence PUFA metabolism in older adults.https://www.mdpi.com/2072-6643/14/11/2336older adultsvitamin B6polyunsaturated fatty acidspyridoxal 5′-phosphatevitamin B6 intakegender |
| spellingShingle | Hyojung Kim Evelyn B. Enrione Vijaya Narayanan Tan Li Adriana Campa Associations of Vitamin B6 Intake and Plasma Pyridoxal 5′-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003–2004 Nutrients older adults vitamin B6 polyunsaturated fatty acids pyridoxal 5′-phosphate vitamin B6 intake gender |
| title | Associations of Vitamin B6 Intake and Plasma Pyridoxal 5′-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003–2004 |
| title_full | Associations of Vitamin B6 Intake and Plasma Pyridoxal 5′-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003–2004 |
| title_fullStr | Associations of Vitamin B6 Intake and Plasma Pyridoxal 5′-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003–2004 |
| title_full_unstemmed | Associations of Vitamin B6 Intake and Plasma Pyridoxal 5′-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003–2004 |
| title_short | Associations of Vitamin B6 Intake and Plasma Pyridoxal 5′-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003–2004 |
| title_sort | associations of vitamin b6 intake and plasma pyridoxal 5 phosphate with plasma polyunsaturated fatty acids in us older adults findings from nhanes 2003 2004 |
| topic | older adults vitamin B6 polyunsaturated fatty acids pyridoxal 5′-phosphate vitamin B6 intake gender |
| url | https://www.mdpi.com/2072-6643/14/11/2336 |
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