The D405N Mutation in the Spike Protein of SARS-CoV-2 Omicron BA.5 Inhibits Spike/Integrins Interaction and Viral Infection of Human Lung Microvascular Endothelial Cells

The D405N Mutation in the Spike Protein of SARS-CoV-2 Omicron BA.5 Inhibits Spike/Integrins Interaction and Viral Infection of Human Lung Microvascular Endothelial Cells

Severe COVID-19 is characterized by angiogenic features, such as intussusceptive angiogenesis, endothelialitis, and activation of procoagulant pathways. This pathological state can be ascribed to a direct SARS-CoV-2 infection of human lung ECs. Recently, we showed the capability of SARS-CoV-2 to inf...

Full description

Bibliographic Details
Main Authors: Antonella Bugatti, Federica Filippini, Serena Messali, Marta Giovanetti, Cosetta Ravelli, Alberto Zani, Massimo Ciccozzi, Arnaldo Caruso, Francesca Caccuri
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Viruses
Subjects:
SARS-CoV-2
Omicron variant
endothelial cell dysfunction
integrins
Online Access:https://www.mdpi.com/1999-4915/15/2/332

Similar Items

Similar Items