Improving Accuracy of Brainstem MRI Volumetry: Effects of Age and Sex, and Normalization Strategies

Improving Accuracy of Brainstem MRI Volumetry: Effects of Age and Sex, and Normalization Strategies

Background: Brainstem-mediated functions are impaired in neurodegenerative diseases and aging. Atrophy can be visualized by MRI. This study investigates extrinsic sources of brainstem volume variability, intrinsic sources of anatomical variability, and the influence of age and sex on the brainstem v...

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Bibliographic Details
Main Authors: Laura Sander, Antal Horvath, Simon Pezold, Simon Andermatt, Michael Amann, Tim Sinnecker, Maria J. Wendebourg, Eva Kesenheimer, Özgür Yaldizli, Ludwig Kappos, Cristina Granziera, Jens Wuerfel, Philippe Cattin, Regina Schlaeger
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Neuroscience
Subjects:
brainstem
covariate
normalization
segmentation
volumetry
MD-GRU
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2020.609422/full

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