Effects of exercise interventions in Alzheimer's disease: A meta‐analysis
Abstract Objective The aim of this study was to investigate the clinical efficacy of exercise intervention in the treatment of patients with Alzheimer's disease (AD) by meta‐analysis. Methods From January 2000 to January 2022, PubMed, Web of Science, Embase, CNKI, and WanFang databases were sea...
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| Format: | Article |
| Language: | English |
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Wiley
2023-07-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.3051 |
| _version_ | 1797781995223252992 |
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| author | Sagor Kumar Roy Jing‐jing Wang Yu‐ming Xu |
| author_facet | Sagor Kumar Roy Jing‐jing Wang Yu‐ming Xu |
| author_sort | Sagor Kumar Roy |
| collection | DOAJ |
| description | Abstract Objective The aim of this study was to investigate the clinical efficacy of exercise intervention in the treatment of patients with Alzheimer's disease (AD) by meta‐analysis. Methods From January 2000 to January 2022, PubMed, Web of Science, Embase, CNKI, and WanFang databases were searched for all studies on the clinical efficacy of exercise intervention in the treatment of AD patients. Stata 17.0 statistical software was used for meta‐analysis. Results Specifically, data of 983 patients were subjected to meta‐analysis, including 463 patients in the control group (conventional drug therapy) and 520 patients in the treatment group (physical exercise on the basis of conventional therapy). The results of meta‐analysis showed that Mini‐Mental State Examination (MMSE) score and Activities of Daily Living Scale (ADL) score in the treatment group were significantly higher than those in the control group. Further subgroup analysis of exercise intervention >16 weeks found that MMSE and ADL scores in the treatment group were significantly higher than those in the control group. Subgroup analysis of exercise intervention ≤16 weeks demonstrated that MMSE and ADL in the treatment group were higher than those in the control group. In addition, the treatment group had a significant lower Neuropsychiatric Inventory (NPI) score compared with the control group (SMD = –0.76, 95% CI (–1.37, –0.16), p = .013); subgroup analysis showed that the NPI score in the treatment group were lower than that in the control group when exercise intervention was >16 weeks [SMD = –1.01, 95% CI (–1.99, –0.04), p = .042] and ≤16 weeks [SMD = 0.43, 95% CI (–0.82, –0.03), p = .034]. Conclusion Exercise intervention can improve the neuropsychiatric symptoms, activities of daily living and cognitive function of AD patients, but the improvement is not significant in case of exercise intervention ≤16 weeks. |
| first_indexed | 2024-03-13T00:04:49Z |
| format | Article |
| id | doaj.art-653def2f083d4bed93b464832fbbcbed |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-03-13T00:04:49Z |
| publishDate | 2023-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-653def2f083d4bed93b464832fbbcbed2023-07-13T04:43:15ZengWileyBrain and Behavior2162-32792023-07-01137n/an/a10.1002/brb3.3051Effects of exercise interventions in Alzheimer's disease: A meta‐analysisSagor Kumar Roy0Jing‐jing Wang1Yu‐ming Xu2Department of Neurology The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan ChinaDepartment of Neurology The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan ChinaDepartment of Neurology The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan ChinaAbstract Objective The aim of this study was to investigate the clinical efficacy of exercise intervention in the treatment of patients with Alzheimer's disease (AD) by meta‐analysis. Methods From January 2000 to January 2022, PubMed, Web of Science, Embase, CNKI, and WanFang databases were searched for all studies on the clinical efficacy of exercise intervention in the treatment of AD patients. Stata 17.0 statistical software was used for meta‐analysis. Results Specifically, data of 983 patients were subjected to meta‐analysis, including 463 patients in the control group (conventional drug therapy) and 520 patients in the treatment group (physical exercise on the basis of conventional therapy). The results of meta‐analysis showed that Mini‐Mental State Examination (MMSE) score and Activities of Daily Living Scale (ADL) score in the treatment group were significantly higher than those in the control group. Further subgroup analysis of exercise intervention >16 weeks found that MMSE and ADL scores in the treatment group were significantly higher than those in the control group. Subgroup analysis of exercise intervention ≤16 weeks demonstrated that MMSE and ADL in the treatment group were higher than those in the control group. In addition, the treatment group had a significant lower Neuropsychiatric Inventory (NPI) score compared with the control group (SMD = –0.76, 95% CI (–1.37, –0.16), p = .013); subgroup analysis showed that the NPI score in the treatment group were lower than that in the control group when exercise intervention was >16 weeks [SMD = –1.01, 95% CI (–1.99, –0.04), p = .042] and ≤16 weeks [SMD = 0.43, 95% CI (–0.82, –0.03), p = .034]. Conclusion Exercise intervention can improve the neuropsychiatric symptoms, activities of daily living and cognitive function of AD patients, but the improvement is not significant in case of exercise intervention ≤16 weeks.https://doi.org/10.1002/brb3.3051Alzheimer ’s diseasedietary interventionexercise therapymeta‐analysis |
| spellingShingle | Sagor Kumar Roy Jing‐jing Wang Yu‐ming Xu Effects of exercise interventions in Alzheimer's disease: A meta‐analysis Brain and Behavior Alzheimer ’s disease dietary intervention exercise therapy meta‐analysis |
| title | Effects of exercise interventions in Alzheimer's disease: A meta‐analysis |
| title_full | Effects of exercise interventions in Alzheimer's disease: A meta‐analysis |
| title_fullStr | Effects of exercise interventions in Alzheimer's disease: A meta‐analysis |
| title_full_unstemmed | Effects of exercise interventions in Alzheimer's disease: A meta‐analysis |
| title_short | Effects of exercise interventions in Alzheimer's disease: A meta‐analysis |
| title_sort | effects of exercise interventions in alzheimer s disease a meta analysis |
| topic | Alzheimer ’s disease dietary intervention exercise therapy meta‐analysis |
| url | https://doi.org/10.1002/brb3.3051 |
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