Molecular Deconvolution Platform to Establish Disease Mechanisms by Surveying GPCR Signaling

Molecular Deconvolution Platform to Establish Disease Mechanisms by Surveying GPCR Signaling

Summary: Despite the wealth of genetic information available, mechanisms underlying pathological effects of disease-associated mutations in components of G protein-coupled receptor (GPCR) signaling cascades remain elusive. In this study, we developed a scalable approach for the functional analysis o...

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Main Authors: Ikuo Masuho, Sreenivas Chavali, Brian S. Muntean, Nickolas K. Skamangas, Kristina Simonyan, Dipak N. Patil, Grant M. Kramer, Laurie Ozelius, M. Madan Babu, Kirill A. Martemyanov
Format: Article
Language:English
Published: Elsevier 2018-07-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718310076

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