Activation of the Erk Pathway Is Required for TGF-β1-Induced EMT In Vitro

Activation of the Erk Pathway Is Required for TGF-β1-Induced EMT In Vitro

Transforming growth factor-β1 (TGF-β1) can be tumorsuppressive through the activation of the Smadmediated signaling pathway. TGF-β1 can also enhance tumor progression by stimulating epithelial-tomesenchymal transition (EMT) through additional pathways. EMT is characterized by the acquisition of a fi...

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Bibliographic Details
Main Authors: Lu Xie, Brian K. Law, Anna M. Chytil, Kimberly A. Brown, Mary E. Aakre, Harold L. Moses
Format: Article
Language:English
Published: Elsevier 2004-09-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
TGF-β
Erk
pathway
EMT
in vitro
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558604800393

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