Nanoscale Topical Pharmacotherapy in Management of Psoriasis: Contemporary Research and Scope
Psoriasis is a typical dermal condition that has been anticipated since prehistoric times when it was mistakenly implicit in being a variant of leprosy. It is an atypical organ-specific autoimmune disorder, which is triggered by the activation of T-cells and/or B-cells. Until now, the pathophysiolog...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/14/1/19 |
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| author | Mohammad Zaki Ahmad Abdul Aleem Mohammed Mohammed S. Algahtani Awanish Mishra Javed Ahmad |
| author_facet | Mohammad Zaki Ahmad Abdul Aleem Mohammed Mohammed S. Algahtani Awanish Mishra Javed Ahmad |
| author_sort | Mohammad Zaki Ahmad |
| collection | DOAJ |
| description | Psoriasis is a typical dermal condition that has been anticipated since prehistoric times when it was mistakenly implicit in being a variant of leprosy. It is an atypical organ-specific autoimmune disorder, which is triggered by the activation of T-cells and/or B-cells. Until now, the pathophysiology of this disease is not completely explicated and still, many research investigations are ongoing. Different approaches have been investigated to treat this dreadful skin disease using various anti-psoriatic drugs of different modes of action through smart drug-delivery systems. Nevertheless, there is no ideal therapy for a complete cure of psoriasis owing to the dearth of an ideal drug-delivery system for anti-psoriatic drugs. The conventional pharmacotherapy approaches for the treatment of psoriasis demand various classes of anti-psoriatic drugs with optimum benefit/risk ratio and insignificant untoward effects. The advancement in nanoscale drug delivery had a great impact on the establishment of a nanomedicine-based therapy for better management of psoriasis in recent times. Nanodrug carriers are exploited to design and develop nanomedicine-based therapy for psoriasis. It has a promising future in the improvement of the therapeutic efficacy of conventional anti-psoriatic drugs. The present manuscript aims to discuss the pathophysiology, conventional pharmacotherapy, and contemporary research in the area of nanoscale topical drug delivery systems for better management of psoriasis including the significance of targeted pharmacotherapy in psoriasis. |
| first_indexed | 2024-03-09T12:08:39Z |
| format | Article |
| id | doaj.art-6541d2a4a3bd4127b229ab804f34ce11 |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-09T12:08:39Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-6541d2a4a3bd4127b229ab804f34ce112023-11-30T22:54:54ZengMDPI AGJournal of Functional Biomaterials2079-49832022-12-011411910.3390/jfb14010019Nanoscale Topical Pharmacotherapy in Management of Psoriasis: Contemporary Research and ScopeMohammad Zaki Ahmad0Abdul Aleem Mohammed1Mohammed S. Algahtani2Awanish Mishra3Javed Ahmad4Department of Pharmaceutics, College of Pharmacy, Najran University, Najran 11001, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, Najran University, Najran 11001, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, Najran University, Najran 11001, Saudi ArabiaDepartment of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Guwahati 781101, Assam, IndiaDepartment of Pharmaceutics, College of Pharmacy, Najran University, Najran 11001, Saudi ArabiaPsoriasis is a typical dermal condition that has been anticipated since prehistoric times when it was mistakenly implicit in being a variant of leprosy. It is an atypical organ-specific autoimmune disorder, which is triggered by the activation of T-cells and/or B-cells. Until now, the pathophysiology of this disease is not completely explicated and still, many research investigations are ongoing. Different approaches have been investigated to treat this dreadful skin disease using various anti-psoriatic drugs of different modes of action through smart drug-delivery systems. Nevertheless, there is no ideal therapy for a complete cure of psoriasis owing to the dearth of an ideal drug-delivery system for anti-psoriatic drugs. The conventional pharmacotherapy approaches for the treatment of psoriasis demand various classes of anti-psoriatic drugs with optimum benefit/risk ratio and insignificant untoward effects. The advancement in nanoscale drug delivery had a great impact on the establishment of a nanomedicine-based therapy for better management of psoriasis in recent times. Nanodrug carriers are exploited to design and develop nanomedicine-based therapy for psoriasis. It has a promising future in the improvement of the therapeutic efficacy of conventional anti-psoriatic drugs. The present manuscript aims to discuss the pathophysiology, conventional pharmacotherapy, and contemporary research in the area of nanoscale topical drug delivery systems for better management of psoriasis including the significance of targeted pharmacotherapy in psoriasis.https://www.mdpi.com/2079-4983/14/1/19psoriasispathophysiologynanomedicinetopical deliverytargeted pharmacotherapy |
| spellingShingle | Mohammad Zaki Ahmad Abdul Aleem Mohammed Mohammed S. Algahtani Awanish Mishra Javed Ahmad Nanoscale Topical Pharmacotherapy in Management of Psoriasis: Contemporary Research and Scope Journal of Functional Biomaterials psoriasis pathophysiology nanomedicine topical delivery targeted pharmacotherapy |
| title | Nanoscale Topical Pharmacotherapy in Management of Psoriasis: Contemporary Research and Scope |
| title_full | Nanoscale Topical Pharmacotherapy in Management of Psoriasis: Contemporary Research and Scope |
| title_fullStr | Nanoscale Topical Pharmacotherapy in Management of Psoriasis: Contemporary Research and Scope |
| title_full_unstemmed | Nanoscale Topical Pharmacotherapy in Management of Psoriasis: Contemporary Research and Scope |
| title_short | Nanoscale Topical Pharmacotherapy in Management of Psoriasis: Contemporary Research and Scope |
| title_sort | nanoscale topical pharmacotherapy in management of psoriasis contemporary research and scope |
| topic | psoriasis pathophysiology nanomedicine topical delivery targeted pharmacotherapy |
| url | https://www.mdpi.com/2079-4983/14/1/19 |
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