Innate lymphoid cells and their role in immune response regulation
Innate lymphoid cells (ILCs) are lymphocytes lacking antigen recognition receptors and become activated in response to cytokines and through microbe-associated molecular pattern (MAMP) receptors. ILCs are found mainly in mucosal tissues and participate in the immune response against infections and i...
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| Format: | Article |
| Language: | English |
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Colegio Mexicano de Inmunología Clínica y Alergia, A.C.
2017-10-01
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| Series: | Revista Alergia México |
| Subjects: | |
| Online Access: | http://revistaalergia.mx/ojs/index.php/ram/article/view/284 |
| _version_ | 1797723620098703360 |
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| author | Bibiana Patricia Ruiz-Sánchez David Cruz-Zárate Iris Estrada-García Isabel Wong-Baeza |
| author_facet | Bibiana Patricia Ruiz-Sánchez David Cruz-Zárate Iris Estrada-García Isabel Wong-Baeza |
| author_sort | Bibiana Patricia Ruiz-Sánchez |
| collection | DOAJ |
| description | Innate lymphoid cells (ILCs) are lymphocytes lacking antigen recognition receptors and become activated in response to cytokines and through microbe-associated molecular pattern (MAMP) receptors. ILCs are found mainly in mucosal tissues and participate in the immune response against infections and in chronic inflammatory conditions. ILCs are divided in ILC-1, ILC-2 and ILC-3, and these cells have analogue functions to those of immune adaptive response lymphocytes Th1, Th2 and Th17. ILC-1 express T-bet, produce IFNγ, protect against infections with intracellular microorganisms and are related to inflammatory bowel disease immunopathology. ILC-2 express GATA3, produce IL-4, IL-5, IL-13 and amphiregulin, protect against parasitic infections and related to allergy and obesity immunopathology. ILC-3 express ROR(γt), produce IL-17 and IL-22, protect against fungal infections and contribute to tolerance to intestinal microbiota and intestinal repair. They are related to inflammatory bowel disease and psoriasis immunopathology. In general terms, ILCs maintain homeostasis and coadjuvate in the protection against infections. |
| first_indexed | 2024-03-12T10:05:21Z |
| format | Article |
| id | doaj.art-65457534af8f4dd28a2ae0093d9ca3c6 |
| institution | Directory Open Access Journal |
| issn | 0002-5151 2448-9190 |
| language | English |
| last_indexed | 2024-03-12T10:05:21Z |
| publishDate | 2017-10-01 |
| publisher | Colegio Mexicano de Inmunología Clínica y Alergia, A.C. |
| record_format | Article |
| series | Revista Alergia México |
| spelling | doaj.art-65457534af8f4dd28a2ae0093d9ca3c62023-09-02T11:20:23ZengColegio Mexicano de Inmunología Clínica y Alergia, A.C.Revista Alergia México0002-51512448-91902017-10-0164334736310.29262/ram.v64i3.284195Innate lymphoid cells and their role in immune response regulationBibiana Patricia Ruiz-Sánchez0David Cruz-Zárate1Iris Estrada-García2Isabel Wong-Baeza3Instituto Politécnico Nacional, Escuela Nacional de Ciencias Biológicas, Posgrado en Inmunología, Ciudad de MéxicoInstituto Politécnico Nacional, Escuela Nacional de Ciencias Biológicas, Posgrado en Inmunología, Ciudad de MéxicoInstituto Politécnico Nacional, Escuela Nacional de Ciencias Biológicas, Departamento de Inmunología, Laboratorio de Inmunología Molecular II, Ciudad de MéxicoInstituto Politécnico Nacional, Escuela Nacional de Ciencias Biológicas, Departamento de Inmunología, Laboratorio de Inmunología Molecular II, Ciudad de MéxicoInnate lymphoid cells (ILCs) are lymphocytes lacking antigen recognition receptors and become activated in response to cytokines and through microbe-associated molecular pattern (MAMP) receptors. ILCs are found mainly in mucosal tissues and participate in the immune response against infections and in chronic inflammatory conditions. ILCs are divided in ILC-1, ILC-2 and ILC-3, and these cells have analogue functions to those of immune adaptive response lymphocytes Th1, Th2 and Th17. ILC-1 express T-bet, produce IFNγ, protect against infections with intracellular microorganisms and are related to inflammatory bowel disease immunopathology. ILC-2 express GATA3, produce IL-4, IL-5, IL-13 and amphiregulin, protect against parasitic infections and related to allergy and obesity immunopathology. ILC-3 express ROR(γt), produce IL-17 and IL-22, protect against fungal infections and contribute to tolerance to intestinal microbiota and intestinal repair. They are related to inflammatory bowel disease and psoriasis immunopathology. In general terms, ILCs maintain homeostasis and coadjuvate in the protection against infections.http://revistaalergia.mx/ojs/index.php/ram/article/view/284Células linfoides innatasInfecciónRespuesta inmuneInflamación crónica |
| spellingShingle | Bibiana Patricia Ruiz-Sánchez David Cruz-Zárate Iris Estrada-García Isabel Wong-Baeza Innate lymphoid cells and their role in immune response regulation Revista Alergia México Células linfoides innatas Infección Respuesta inmune Inflamación crónica |
| title | Innate lymphoid cells and their role in immune response regulation |
| title_full | Innate lymphoid cells and their role in immune response regulation |
| title_fullStr | Innate lymphoid cells and their role in immune response regulation |
| title_full_unstemmed | Innate lymphoid cells and their role in immune response regulation |
| title_short | Innate lymphoid cells and their role in immune response regulation |
| title_sort | innate lymphoid cells and their role in immune response regulation |
| topic | Células linfoides innatas Infección Respuesta inmune Inflamación crónica |
| url | http://revistaalergia.mx/ojs/index.php/ram/article/view/284 |
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