Exploring the Potential Anti-Inflammatory and Wound-Healing Proprieties of <i>Cepaea hortensis</i> Snail Mucin
Long before its popularization as a skincare ingredient, snail slime was reported to have a variety of health-promoting attributes. Its medicinal use involved the treatment of ailments, such as anthrax, hernias, stomach pain, chest pain, as well as tuberculosis. The main aim of this study was to inv...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Cosmetics |
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| Online Access: | https://www.mdpi.com/2079-9284/10/6/170 |
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| author | Fatima Errajouani Hanane Bakrim Sohaib Hourfane Adnane Louajri João Miguel Rocha Noureddine El Aouad Amin Laglaoui |
| author_facet | Fatima Errajouani Hanane Bakrim Sohaib Hourfane Adnane Louajri João Miguel Rocha Noureddine El Aouad Amin Laglaoui |
| author_sort | Fatima Errajouani |
| collection | DOAJ |
| description | Long before its popularization as a skincare ingredient, snail slime was reported to have a variety of health-promoting attributes. Its medicinal use involved the treatment of ailments, such as anthrax, hernias, stomach pain, chest pain, as well as tuberculosis. The main aim of this study was to investigate the anti-inflammatory and wound-healing properties of snail slime from <i>Cepaea hortensis</i> (Müller, 1774) (brown garden snail). The slime was extracted by a mild method, and the anti-inflammatory characteristics were determined by croton-oil-induced mouse-ear edema. The histological study showed that the snail slime exerts its action at the level of inflammatory mediators, explaining the drastic decrease of edema (59% in comparison to the 47% of indomethacin). The daily application of 50 µL (15 mg/kg) of snail slime on excision wounds in rabbits proved to induce an almost full tissue repair after 24 days of treatment (87.80–92.7% wound closure in width and length, respectively). Analysis of the slime’s safety aspect allowed affirming the nontoxicity of snail slime on both the skin and eyes. |
| first_indexed | 2024-03-08T20:52:42Z |
| format | Article |
| id | doaj.art-6545e6ddbb104f1a990246db2a4ccdd5 |
| institution | Directory Open Access Journal |
| issn | 2079-9284 |
| language | English |
| last_indexed | 2024-03-08T20:52:42Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cosmetics |
| spelling | doaj.art-6545e6ddbb104f1a990246db2a4ccdd52023-12-22T14:01:39ZengMDPI AGCosmetics2079-92842023-12-0110617010.3390/cosmetics10060170Exploring the Potential Anti-Inflammatory and Wound-Healing Proprieties of <i>Cepaea hortensis</i> Snail MucinFatima Errajouani0Hanane Bakrim1Sohaib Hourfane2Adnane Louajri3João Miguel Rocha4Noureddine El Aouad5Amin Laglaoui6Biosciences, Environment and Health Laboratory, Faculty of Sciences—Tetouan, University Abdelmalek Essaâdi, Tetouan 93000, MoroccoBiotechnology and Biomolecules Engineering Research Team (BBERT), Faculty of Science and Technology—Tangier, University Abdelmalik Essaâdi, Tetouan 93000, MoroccoLaboratory of Life and Health Sciences, Faculty of Medicine and Pharmacy, Route de Rabat km 15 Gzenaya BP 365 Tanger, University Abdelmalek Essaâdi, Tetouan 9300, MoroccoBiosciences, Environment and Health Laboratory, Faculty of Sciences—Tetouan, University Abdelmalek Essaâdi, Tetouan 93000, MoroccoUniversidade Católica Portuguesa, CBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, PortugalLaboratory of Life and Health Sciences, Faculty of Medicine and Pharmacy, Route de Rabat km 15 Gzenaya BP 365 Tanger, University Abdelmalek Essaâdi, Tetouan 9300, MoroccoBiotechnology and Biomolecules Engineering Research Team (BBERT), Faculty of Science and Technology—Tangier, University Abdelmalik Essaâdi, Tetouan 93000, MoroccoLong before its popularization as a skincare ingredient, snail slime was reported to have a variety of health-promoting attributes. Its medicinal use involved the treatment of ailments, such as anthrax, hernias, stomach pain, chest pain, as well as tuberculosis. The main aim of this study was to investigate the anti-inflammatory and wound-healing properties of snail slime from <i>Cepaea hortensis</i> (Müller, 1774) (brown garden snail). The slime was extracted by a mild method, and the anti-inflammatory characteristics were determined by croton-oil-induced mouse-ear edema. The histological study showed that the snail slime exerts its action at the level of inflammatory mediators, explaining the drastic decrease of edema (59% in comparison to the 47% of indomethacin). The daily application of 50 µL (15 mg/kg) of snail slime on excision wounds in rabbits proved to induce an almost full tissue repair after 24 days of treatment (87.80–92.7% wound closure in width and length, respectively). Analysis of the slime’s safety aspect allowed affirming the nontoxicity of snail slime on both the skin and eyes.https://www.mdpi.com/2079-9284/10/6/170snail slimeanti-inflammatorywound healingtoxicityedemapharmacological properties |
| spellingShingle | Fatima Errajouani Hanane Bakrim Sohaib Hourfane Adnane Louajri João Miguel Rocha Noureddine El Aouad Amin Laglaoui Exploring the Potential Anti-Inflammatory and Wound-Healing Proprieties of <i>Cepaea hortensis</i> Snail Mucin Cosmetics snail slime anti-inflammatory wound healing toxicity edema pharmacological properties |
| title | Exploring the Potential Anti-Inflammatory and Wound-Healing Proprieties of <i>Cepaea hortensis</i> Snail Mucin |
| title_full | Exploring the Potential Anti-Inflammatory and Wound-Healing Proprieties of <i>Cepaea hortensis</i> Snail Mucin |
| title_fullStr | Exploring the Potential Anti-Inflammatory and Wound-Healing Proprieties of <i>Cepaea hortensis</i> Snail Mucin |
| title_full_unstemmed | Exploring the Potential Anti-Inflammatory and Wound-Healing Proprieties of <i>Cepaea hortensis</i> Snail Mucin |
| title_short | Exploring the Potential Anti-Inflammatory and Wound-Healing Proprieties of <i>Cepaea hortensis</i> Snail Mucin |
| title_sort | exploring the potential anti inflammatory and wound healing proprieties of i cepaea hortensis i snail mucin |
| topic | snail slime anti-inflammatory wound healing toxicity edema pharmacological properties |
| url | https://www.mdpi.com/2079-9284/10/6/170 |
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