Preventing SARS-CoV-2 infection by blocking a tissue serine protease
Currently, there are no proven pharmacologic interventions to reduce the clinical impact and prevent complications of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, the cause of the ongoing Coronavirus Disease of 2019 (COVID-19) pandemic. Selecting specific pharmacologic...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2020-06-01
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| Series: | Therapeutic Advances in Infectious Disease |
| Online Access: | https://doi.org/10.1177/2049936120933076 |
| _version_ | 1818657877968027648 |
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| author | Katherine C. Jankousky Jonathan Schultz Samuel Windham Andrés F. Henao-Martínez Carlos Franco-Paredes Leland Shapiro |
| author_facet | Katherine C. Jankousky Jonathan Schultz Samuel Windham Andrés F. Henao-Martínez Carlos Franco-Paredes Leland Shapiro |
| author_sort | Katherine C. Jankousky |
| collection | DOAJ |
| description | Currently, there are no proven pharmacologic interventions to reduce the clinical impact and prevent complications of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, the cause of the ongoing Coronavirus Disease of 2019 (COVID-19) pandemic. Selecting specific pharmacological targets for the treatment of viral pathogens has traditionally relied in blockage of specific steps in their replicative lifecycle in human cells. However, an alternative approach is reducing the molecular cleavage of the viral surface spike protein of SARS-CoV-2 to prevent viral entry into epithelial cells. |
| first_indexed | 2024-12-17T03:48:28Z |
| format | Article |
| id | doaj.art-65464378dc944b55b98cd84f68fb76e2 |
| institution | Directory Open Access Journal |
| issn | 2049-937X |
| language | English |
| last_indexed | 2024-12-17T03:48:28Z |
| publishDate | 2020-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Infectious Disease |
| spelling | doaj.art-65464378dc944b55b98cd84f68fb76e22022-12-21T22:04:50ZengSAGE PublishingTherapeutic Advances in Infectious Disease2049-937X2020-06-01710.1177/2049936120933076Preventing SARS-CoV-2 infection by blocking a tissue serine proteaseKatherine C. JankouskyJonathan SchultzSamuel WindhamAndrés F. Henao-MartínezCarlos Franco-ParedesLeland ShapiroCurrently, there are no proven pharmacologic interventions to reduce the clinical impact and prevent complications of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, the cause of the ongoing Coronavirus Disease of 2019 (COVID-19) pandemic. Selecting specific pharmacological targets for the treatment of viral pathogens has traditionally relied in blockage of specific steps in their replicative lifecycle in human cells. However, an alternative approach is reducing the molecular cleavage of the viral surface spike protein of SARS-CoV-2 to prevent viral entry into epithelial cells.https://doi.org/10.1177/2049936120933076 |
| spellingShingle | Katherine C. Jankousky Jonathan Schultz Samuel Windham Andrés F. Henao-Martínez Carlos Franco-Paredes Leland Shapiro Preventing SARS-CoV-2 infection by blocking a tissue serine protease Therapeutic Advances in Infectious Disease |
| title | Preventing SARS-CoV-2 infection by blocking a tissue serine protease |
| title_full | Preventing SARS-CoV-2 infection by blocking a tissue serine protease |
| title_fullStr | Preventing SARS-CoV-2 infection by blocking a tissue serine protease |
| title_full_unstemmed | Preventing SARS-CoV-2 infection by blocking a tissue serine protease |
| title_short | Preventing SARS-CoV-2 infection by blocking a tissue serine protease |
| title_sort | preventing sars cov 2 infection by blocking a tissue serine protease |
| url | https://doi.org/10.1177/2049936120933076 |
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