On the Usefulness of Two Small-Scale In Vitro Setups in the Evaluation of Luminal Precipitation of Lipophilic Weak Bases in Early Formulation Development

On the Usefulness of Two Small-Scale In Vitro Setups in the Evaluation of Luminal Precipitation of Lipophilic Weak Bases in Early Formulation Development

A small-scale biphasic dissolution setup and a small-scale dissolution-permeation (D-P) setup were evaluated for their usefulness in simulating the luminal precipitation of three lipophilic weak bases—dipyridamole, ketoconazole and itraconazole. The transition from the gastric to intestina...

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Bibliographic Details
Main Authors: Patrick J. O’Dwyer, Georgios Imanidis, Karl J. Box, Christos Reppas
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Pharmaceutics
Subjects:
precipitation
supersaturation
biorelevant
in vitro techniques
pbpk modelling
biphasic dissolution
dissolution-permeation
Online Access:https://www.mdpi.com/1999-4923/12/3/272

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