Hiding in Plain Sight: Modern Thiamine Deficiency
Thiamine or vitamin B1 is an essential, water-soluble vitamin required for mitochondrial energetics—the production of adenosine triphosphate (ATP). It is a critical and rate-limiting cofactor to multiple enzymes involved in this process, including those at the entry points and at critical junctures...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-09-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/10/10/2595 |
| _version_ | 1797515005164257280 |
|---|---|
| author | Chandler Marrs Derrick Lonsdale |
| author_facet | Chandler Marrs Derrick Lonsdale |
| author_sort | Chandler Marrs |
| collection | DOAJ |
| description | Thiamine or vitamin B1 is an essential, water-soluble vitamin required for mitochondrial energetics—the production of adenosine triphosphate (ATP). It is a critical and rate-limiting cofactor to multiple enzymes involved in this process, including those at the entry points and at critical junctures for the glucose, fatty acid, and amino acid pathways. It has a very short half-life, limited storage capacity, and is susceptible to degradation and depletion by a number of products that epitomize modern life, including environmental and pharmaceutical chemicals. The RDA for thiamine is 1.1–1.2 mg for adult females and males, respectively. With an average diet, even a poor one, it is not difficult to meet that daily requirement, and yet, measurable thiamine deficiency has been observed across multiple patient populations with incidence rates ranging from 20% to over 90% depending upon the study. This suggests that the RDA requirement may be insufficient to meet the demands of modern living. Inasmuch as thiamine deficiency syndromes pose great risk of chronic morbidity, and if left untreated, mortality, a more comprehensive understanding thiamine chemistry, relative to energy production, modern living, and disease, may prove useful. |
| first_indexed | 2024-03-10T06:39:30Z |
| format | Article |
| id | doaj.art-654c17ded26f4691aee07a240570fd41 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T06:39:30Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-654c17ded26f4691aee07a240570fd412023-11-22T17:46:06ZengMDPI AGCells2073-44092021-09-011010259510.3390/cells10102595Hiding in Plain Sight: Modern Thiamine DeficiencyChandler Marrs0Derrick Lonsdale1Independent Researcher, Henderson, NV 89074, USAEmeritus, Cleveland Clinic, Cleveland, OH 44195, USAThiamine or vitamin B1 is an essential, water-soluble vitamin required for mitochondrial energetics—the production of adenosine triphosphate (ATP). It is a critical and rate-limiting cofactor to multiple enzymes involved in this process, including those at the entry points and at critical junctures for the glucose, fatty acid, and amino acid pathways. It has a very short half-life, limited storage capacity, and is susceptible to degradation and depletion by a number of products that epitomize modern life, including environmental and pharmaceutical chemicals. The RDA for thiamine is 1.1–1.2 mg for adult females and males, respectively. With an average diet, even a poor one, it is not difficult to meet that daily requirement, and yet, measurable thiamine deficiency has been observed across multiple patient populations with incidence rates ranging from 20% to over 90% depending upon the study. This suggests that the RDA requirement may be insufficient to meet the demands of modern living. Inasmuch as thiamine deficiency syndromes pose great risk of chronic morbidity, and if left untreated, mortality, a more comprehensive understanding thiamine chemistry, relative to energy production, modern living, and disease, may prove useful.https://www.mdpi.com/2073-4409/10/10/2595thiamine deficiencythiamine deficiency metabolic diseasethiamine deficiency hyperglycemiathiamine deficiency critical illness |
| spellingShingle | Chandler Marrs Derrick Lonsdale Hiding in Plain Sight: Modern Thiamine Deficiency Cells thiamine deficiency thiamine deficiency metabolic disease thiamine deficiency hyperglycemia thiamine deficiency critical illness |
| title | Hiding in Plain Sight: Modern Thiamine Deficiency |
| title_full | Hiding in Plain Sight: Modern Thiamine Deficiency |
| title_fullStr | Hiding in Plain Sight: Modern Thiamine Deficiency |
| title_full_unstemmed | Hiding in Plain Sight: Modern Thiamine Deficiency |
| title_short | Hiding in Plain Sight: Modern Thiamine Deficiency |
| title_sort | hiding in plain sight modern thiamine deficiency |
| topic | thiamine deficiency thiamine deficiency metabolic disease thiamine deficiency hyperglycemia thiamine deficiency critical illness |
| url | https://www.mdpi.com/2073-4409/10/10/2595 |
| work_keys_str_mv | AT chandlermarrs hidinginplainsightmodernthiaminedeficiency AT derricklonsdale hidinginplainsightmodernthiaminedeficiency |