Phloroglucinol Derivatives in Plant-Beneficial <i>Pseudomonas</i> spp.: Biosynthesis, Regulation, and Functions
Plant-beneficial <i>Pseudomonas</i> spp. aggressively colonize the rhizosphere and produce numerous secondary metabolites, such as 2,4-diacetylphloroglucinol (DAPG). DAPG is a phloroglucinol derivative that contributes to disease suppression, thanks to its broad-spectrum antimicrobial ac...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/11/3/182 |
| _version_ | 1797540624733306880 |
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| author | Adrien Biessy Martin Filion |
| author_facet | Adrien Biessy Martin Filion |
| author_sort | Adrien Biessy |
| collection | DOAJ |
| description | Plant-beneficial <i>Pseudomonas</i> spp. aggressively colonize the rhizosphere and produce numerous secondary metabolites, such as 2,4-diacetylphloroglucinol (DAPG). DAPG is a phloroglucinol derivative that contributes to disease suppression, thanks to its broad-spectrum antimicrobial activity. A famous example of this biocontrol activity has been previously described in the context of wheat monoculture where a decline in take-all disease (caused by the ascomycete <i>Gaeumannomyces tritici</i>) has been shown to be associated with rhizosphere colonization by DAPG-producing <i>Pseudomonas</i> spp. In this review, we discuss the biosynthesis and regulation of phloroglucinol derivatives in the genus <i>Pseudomonas</i>, as well as investigate the role played by DAPG-producing <i>Pseudomonas</i> spp. in natural soil suppressiveness. We also tackle the mode of action of phloroglucinol derivatives, which can act as antibiotics, signalling molecules and, in some cases, even as pathogenicity factors. Finally, we discuss the genetic and genomic diversity of DAPG-producing <i>Pseudomonas</i> spp. as well as its importance for improving the biocontrol of plant pathogens. |
| first_indexed | 2024-03-10T13:03:51Z |
| format | Article |
| id | doaj.art-654ca86792a44f5d9491595e50d6a5ca |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T13:03:51Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-654ca86792a44f5d9491595e50d6a5ca2023-11-21T11:16:25ZengMDPI AGMetabolites2218-19892021-03-0111318210.3390/metabo11030182Phloroglucinol Derivatives in Plant-Beneficial <i>Pseudomonas</i> spp.: Biosynthesis, Regulation, and FunctionsAdrien Biessy0Martin Filion1Agriculture and Agri-Food Canada, Saint-Jean-sur-Richelieu Research and Development Center, Saint-Jean-sur-Richelieu, QC J3B 7B5, CanadaAgriculture and Agri-Food Canada, Saint-Jean-sur-Richelieu Research and Development Center, Saint-Jean-sur-Richelieu, QC J3B 7B5, CanadaPlant-beneficial <i>Pseudomonas</i> spp. aggressively colonize the rhizosphere and produce numerous secondary metabolites, such as 2,4-diacetylphloroglucinol (DAPG). DAPG is a phloroglucinol derivative that contributes to disease suppression, thanks to its broad-spectrum antimicrobial activity. A famous example of this biocontrol activity has been previously described in the context of wheat monoculture where a decline in take-all disease (caused by the ascomycete <i>Gaeumannomyces tritici</i>) has been shown to be associated with rhizosphere colonization by DAPG-producing <i>Pseudomonas</i> spp. In this review, we discuss the biosynthesis and regulation of phloroglucinol derivatives in the genus <i>Pseudomonas</i>, as well as investigate the role played by DAPG-producing <i>Pseudomonas</i> spp. in natural soil suppressiveness. We also tackle the mode of action of phloroglucinol derivatives, which can act as antibiotics, signalling molecules and, in some cases, even as pathogenicity factors. Finally, we discuss the genetic and genomic diversity of DAPG-producing <i>Pseudomonas</i> spp. as well as its importance for improving the biocontrol of plant pathogens.https://www.mdpi.com/2218-1989/11/3/1822,4-diacetylphloroglucinolDAPG<i>Pseudomonas</i>biocontrolantibiotic |
| spellingShingle | Adrien Biessy Martin Filion Phloroglucinol Derivatives in Plant-Beneficial <i>Pseudomonas</i> spp.: Biosynthesis, Regulation, and Functions Metabolites 2,4-diacetylphloroglucinol DAPG <i>Pseudomonas</i> biocontrol antibiotic |
| title | Phloroglucinol Derivatives in Plant-Beneficial <i>Pseudomonas</i> spp.: Biosynthesis, Regulation, and Functions |
| title_full | Phloroglucinol Derivatives in Plant-Beneficial <i>Pseudomonas</i> spp.: Biosynthesis, Regulation, and Functions |
| title_fullStr | Phloroglucinol Derivatives in Plant-Beneficial <i>Pseudomonas</i> spp.: Biosynthesis, Regulation, and Functions |
| title_full_unstemmed | Phloroglucinol Derivatives in Plant-Beneficial <i>Pseudomonas</i> spp.: Biosynthesis, Regulation, and Functions |
| title_short | Phloroglucinol Derivatives in Plant-Beneficial <i>Pseudomonas</i> spp.: Biosynthesis, Regulation, and Functions |
| title_sort | phloroglucinol derivatives in plant beneficial i pseudomonas i spp biosynthesis regulation and functions |
| topic | 2,4-diacetylphloroglucinol DAPG <i>Pseudomonas</i> biocontrol antibiotic |
| url | https://www.mdpi.com/2218-1989/11/3/182 |
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