Peptide-Based Electrospun Fibers: Current Status and Emerging Developments
Electrospinning is a well-known, straightforward, and versatile technique, widely used for the preparation of fibers by electrifying a polymer solution. However, a high molecular weight is not essential for obtaining uniform electrospun fibers; in fact, the primary criterion to succeed is the presen...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/11/5/1262 |
| _version_ | 1797534518724263936 |
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| author | Raffaella Bucci Evangelos Georgilis Alexander M. Bittner Maria L. Gelmi Francesca Clerici |
| author_facet | Raffaella Bucci Evangelos Georgilis Alexander M. Bittner Maria L. Gelmi Francesca Clerici |
| author_sort | Raffaella Bucci |
| collection | DOAJ |
| description | Electrospinning is a well-known, straightforward, and versatile technique, widely used for the preparation of fibers by electrifying a polymer solution. However, a high molecular weight is not essential for obtaining uniform electrospun fibers; in fact, the primary criterion to succeed is the presence of sufficient intermolecular interactions, which function similar to chain entanglements. Some small molecules able to self-assemble have been electrospun from solution into fibers and, among them, peptides containing both natural and non-natural amino acids are of particular relevance. Nowadays, the use of peptides for this purpose is at an early stage, but it is gaining more and more interest, and we are now witnessing the transition from basic research towards applications. Considering the novelty in the relevant processing, the aim of this review is to analyze the state of the art from the early 2000s on. Moreover, advantages and drawbacks in using peptides as the main or sole component for generating electrospun nanofibers will be discussed. Characterization techniques that are specifically targeted to the produced peptide fibers are presented. |
| first_indexed | 2024-03-10T11:30:38Z |
| format | Article |
| id | doaj.art-654d1d7e533748958d8cc01822e66411 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T11:30:38Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-654d1d7e533748958d8cc01822e664112023-11-21T19:15:18ZengMDPI AGNanomaterials2079-49912021-05-01115126210.3390/nano11051262Peptide-Based Electrospun Fibers: Current Status and Emerging DevelopmentsRaffaella Bucci0Evangelos Georgilis1Alexander M. Bittner2Maria L. Gelmi3Francesca Clerici4Department of Pharmaceutical Sciences, University of Milan, Via Venezian 21, 20133 Milan, ItalyCIC nanoGUNE, (BRTA) Tolosa Hiribidea 76, 20018 Donostia-San Sebastián, SpainCIC nanoGUNE, (BRTA) Tolosa Hiribidea 76, 20018 Donostia-San Sebastián, SpainDepartment of Pharmaceutical Sciences, University of Milan, Via Venezian 21, 20133 Milan, ItalyDepartment of Pharmaceutical Sciences, University of Milan, Via Venezian 21, 20133 Milan, ItalyElectrospinning is a well-known, straightforward, and versatile technique, widely used for the preparation of fibers by electrifying a polymer solution. However, a high molecular weight is not essential for obtaining uniform electrospun fibers; in fact, the primary criterion to succeed is the presence of sufficient intermolecular interactions, which function similar to chain entanglements. Some small molecules able to self-assemble have been electrospun from solution into fibers and, among them, peptides containing both natural and non-natural amino acids are of particular relevance. Nowadays, the use of peptides for this purpose is at an early stage, but it is gaining more and more interest, and we are now witnessing the transition from basic research towards applications. Considering the novelty in the relevant processing, the aim of this review is to analyze the state of the art from the early 2000s on. Moreover, advantages and drawbacks in using peptides as the main or sole component for generating electrospun nanofibers will be discussed. Characterization techniques that are specifically targeted to the produced peptide fibers are presented.https://www.mdpi.com/2079-4991/11/5/1262peptidespeptidomimeticspeptide-based electrospun nanofibersself-assemblyelectrospinning |
| spellingShingle | Raffaella Bucci Evangelos Georgilis Alexander M. Bittner Maria L. Gelmi Francesca Clerici Peptide-Based Electrospun Fibers: Current Status and Emerging Developments Nanomaterials peptides peptidomimetics peptide-based electrospun nanofibers self-assembly electrospinning |
| title | Peptide-Based Electrospun Fibers: Current Status and Emerging Developments |
| title_full | Peptide-Based Electrospun Fibers: Current Status and Emerging Developments |
| title_fullStr | Peptide-Based Electrospun Fibers: Current Status and Emerging Developments |
| title_full_unstemmed | Peptide-Based Electrospun Fibers: Current Status and Emerging Developments |
| title_short | Peptide-Based Electrospun Fibers: Current Status and Emerging Developments |
| title_sort | peptide based electrospun fibers current status and emerging developments |
| topic | peptides peptidomimetics peptide-based electrospun nanofibers self-assembly electrospinning |
| url | https://www.mdpi.com/2079-4991/11/5/1262 |
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