Relationship of the AKR1B1 rs759853 and rs9640883 with the development of diabetic retinopathy
Background: In type 2 diabetes mellitus (DM2), hyperglycemia activates the polyol pathway of glucose metabolism, resulting in accumulation of sorbitol and fructose. Polymorphism of aldose reductase (a key enzyme of the poliol pathway) gene (AKR1B1) influences the activity of the polyol pathway and m...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Ukrainian Society of Ophthalmologists
2017-04-01
|
| Series: | Journal of Ophthalmology |
| Subjects: | |
| Online Access: | https://www.ozhurnal.com/en/archive/2017/2/1-fulltext |