Organomegaly in Mali before and after praziquantel treatment. A possible association with Schistosoma haematobium
Continuous exposure to schistosome-infested water results in acute and chronic morbidity in all ages. We analysed occurence of organomegaly via ultrasonography and investigated a possible additive effect of dual-dose drug administration in 401 Schistosoma haematobium infected individuals from a high...
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Elsevier
2017-11-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844017300968 |
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| author | Chalotte Willemann Stecher Henry Madsen Shona Wilson Moussa Sacko Christian Wejse Adama D. Keita Aly Landouré Mamadou S. Traoré Per Kallestrup Eskild Petersen Birgitte Vennervald |
| author_facet | Chalotte Willemann Stecher Henry Madsen Shona Wilson Moussa Sacko Christian Wejse Adama D. Keita Aly Landouré Mamadou S. Traoré Per Kallestrup Eskild Petersen Birgitte Vennervald |
| author_sort | Chalotte Willemann Stecher |
| collection | DOAJ |
| description | Continuous exposure to schistosome-infested water results in acute and chronic morbidity in all ages. We analysed occurence of organomegaly via ultrasonography and investigated a possible additive effect of dual-dose drug administration in 401 Schistosoma haematobium infected individuals from a highly endemic area in Mali. Mean intensity of infection at baseline (22.0 eggs per 10 ml) was reduced to 0.22 eggs per 10 ml 9 weeks after treatment (both treatments combined). Odds of persistent infection among those given dual-dose treatment was 41% of that in people given single dose (b = 0.41; p = 0.05; 95% CI 0.17–1.00), but after two years, 70.7% of the 157 participants, who completed the survey, were re-infected with no significant difference in prevalence and intensity of infection between treatment groups. Resolution of organomegaly occurred in all age groups after treatment. A novel association between Schistosoma haematobium infection and moderate portal vein enlargement was found in 35% (n: 55). Severe portal vein diameter enlargement was found in 3.2%. After two years, moderate hepatomegaly was present in 50.6%, moderate splenomegaly in 45.6% and moderate portal vein diameter enlargement in 19%. A subsequent dose of PZQ did not provide any additional long-term advantages. |
| first_indexed | 2024-12-12T21:32:22Z |
| format | Article |
| id | doaj.art-654f749c5984472db654786a7fef91d3 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-12T21:32:22Z |
| publishDate | 2017-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-654f749c5984472db654786a7fef91d32022-12-22T00:11:17ZengElsevierHeliyon2405-84402017-11-01311e00440Organomegaly in Mali before and after praziquantel treatment. A possible association with Schistosoma haematobiumChalotte Willemann Stecher0Henry Madsen1Shona Wilson2Moussa Sacko3Christian Wejse4Adama D. Keita5Aly Landouré6Mamadou S. Traoré7Per Kallestrup8Eskild Petersen9Birgitte Vennervald10Department of Infectious Diseases, Aarhus University Hospital, Denmark; Center for Global Health (GloHAU), Department of Public Health, Aarhus University, Denmark; Corresponding author.Section for Parasitology and Aquatic Diseases, SUND, University of Copenhagen, DenmarkDepartment of Pathology, University of Cambridge, United KingdomLaboratory of Parasitology, Institut National de Recerche en Sante Publique, Bamako, MaliDepartment of Infectious Diseases, Aarhus University Hospital, Denmark; Center for Global Health (GloHAU), Department of Public Health, Aarhus University, DenmarkUniversity of Sciences, Techniques and Technology, Bamako, MaliLaboratory of Parasitology, Institut National de Recerche en Sante Publique, Bamako, MaliLaboratory of Parasitology, Institut National de Recerche en Sante Publique, Bamako, MaliCenter for Global Health (GloHAU), Department of Public Health, Aarhus University, DenmarkDepartment of Infectious Diseases, The Royal Hospital, P.O. Box 1331, Muscat, Oman; Institute for Clinical Medicine, University of Aarhus, DenmarkSection for Parasitology and Aquatic Diseases, SUND, University of Copenhagen, DenmarkContinuous exposure to schistosome-infested water results in acute and chronic morbidity in all ages. We analysed occurence of organomegaly via ultrasonography and investigated a possible additive effect of dual-dose drug administration in 401 Schistosoma haematobium infected individuals from a highly endemic area in Mali. Mean intensity of infection at baseline (22.0 eggs per 10 ml) was reduced to 0.22 eggs per 10 ml 9 weeks after treatment (both treatments combined). Odds of persistent infection among those given dual-dose treatment was 41% of that in people given single dose (b = 0.41; p = 0.05; 95% CI 0.17–1.00), but after two years, 70.7% of the 157 participants, who completed the survey, were re-infected with no significant difference in prevalence and intensity of infection between treatment groups. Resolution of organomegaly occurred in all age groups after treatment. A novel association between Schistosoma haematobium infection and moderate portal vein enlargement was found in 35% (n: 55). Severe portal vein diameter enlargement was found in 3.2%. After two years, moderate hepatomegaly was present in 50.6%, moderate splenomegaly in 45.6% and moderate portal vein diameter enlargement in 19%. A subsequent dose of PZQ did not provide any additional long-term advantages.http://www.sciencedirect.com/science/article/pii/S2405844017300968Infectious disease |
| spellingShingle | Chalotte Willemann Stecher Henry Madsen Shona Wilson Moussa Sacko Christian Wejse Adama D. Keita Aly Landouré Mamadou S. Traoré Per Kallestrup Eskild Petersen Birgitte Vennervald Organomegaly in Mali before and after praziquantel treatment. A possible association with Schistosoma haematobium Heliyon Infectious disease |
| title | Organomegaly in Mali before and after praziquantel treatment. A possible association with Schistosoma haematobium |
| title_full | Organomegaly in Mali before and after praziquantel treatment. A possible association with Schistosoma haematobium |
| title_fullStr | Organomegaly in Mali before and after praziquantel treatment. A possible association with Schistosoma haematobium |
| title_full_unstemmed | Organomegaly in Mali before and after praziquantel treatment. A possible association with Schistosoma haematobium |
| title_short | Organomegaly in Mali before and after praziquantel treatment. A possible association with Schistosoma haematobium |
| title_sort | organomegaly in mali before and after praziquantel treatment a possible association with schistosoma haematobium |
| topic | Infectious disease |
| url | http://www.sciencedirect.com/science/article/pii/S2405844017300968 |
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