Body mass index and weight change during initial period of chemotherapy affect survival outcome in advanced biliary tract cancer patients.
The impact of obesity on survival is known to vary in different cancers. Advanced biliary tract cancer was rarely analyzed about the relationship between obesity and prognosis. We performed this study to evaluate the BMI and body weight change as prognostic factors for advanced biliary tract cancer...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5880377?pdf=render |
| _version_ | 1818135317943681024 |
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| author | Jinwoo Kang Sang Hyub Lee Jun Hyuk Son Jae Woo Lee Young Hoon Choi Jin Ho Choi Woo Hyun Paik Ji Kon Ryu Yong-Tae Kim |
| author_facet | Jinwoo Kang Sang Hyub Lee Jun Hyuk Son Jae Woo Lee Young Hoon Choi Jin Ho Choi Woo Hyun Paik Ji Kon Ryu Yong-Tae Kim |
| author_sort | Jinwoo Kang |
| collection | DOAJ |
| description | The impact of obesity on survival is known to vary in different cancers. Advanced biliary tract cancer was rarely analyzed about the relationship between obesity and prognosis. We performed this study to evaluate the BMI and body weight change as prognostic factors for advanced biliary tract cancer patients with palliative chemotherapy.Between January 2005 and December 2016, two hundred and seventy-six patients who underwent chemotherapy for biliary tract cancer were retrospectively analyzed. The relationship between BMI (kg/m2) and clinical outcomes including overall and progression-free survival was assessed. Additionally the relationship between change in body composition and overall survival was evaluated.Median overall survival was 9.7 months for underweight patients, 10.1 months for normal patients, 15.8 months for overweight group, 13.1 months for obese patients, respectively. (p = 0.047) Univariate analysis showed that BMI, stage III, age less than 64 year-old, gallbladder cancer, operation, radiotherapy and ECOG performance were significantly associated with better survival. Compared with normal patients, overweight patients (BMI 23-24.9kg/m2) had a reduced risk of mortality in multivariate analysis (HR 0.632; 95% CI 0.436-0.918, p = 0.016). In the additional analysis for the effect of changes in body weight and BMI to the overall survival, decrease in body weight and BMI (HR 1.410, 95% CI 1.168-1.986, p = 0.046) was associated with a shorter in overall survival.Overweight status and the maintenance of body weight during the initial period of chemotherapy are important and independent predictors of better overall survival in advanced biliary tract cancer patients. |
| first_indexed | 2024-12-11T09:22:36Z |
| format | Article |
| id | doaj.art-654fbd9c4b144fcaac78a16a9ce447c5 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T09:22:36Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-654fbd9c4b144fcaac78a16a9ce447c52022-12-22T01:13:13ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01134e019511810.1371/journal.pone.0195118Body mass index and weight change during initial period of chemotherapy affect survival outcome in advanced biliary tract cancer patients.Jinwoo KangSang Hyub LeeJun Hyuk SonJae Woo LeeYoung Hoon ChoiJin Ho ChoiWoo Hyun PaikJi Kon RyuYong-Tae KimThe impact of obesity on survival is known to vary in different cancers. Advanced biliary tract cancer was rarely analyzed about the relationship between obesity and prognosis. We performed this study to evaluate the BMI and body weight change as prognostic factors for advanced biliary tract cancer patients with palliative chemotherapy.Between January 2005 and December 2016, two hundred and seventy-six patients who underwent chemotherapy for biliary tract cancer were retrospectively analyzed. The relationship between BMI (kg/m2) and clinical outcomes including overall and progression-free survival was assessed. Additionally the relationship between change in body composition and overall survival was evaluated.Median overall survival was 9.7 months for underweight patients, 10.1 months for normal patients, 15.8 months for overweight group, 13.1 months for obese patients, respectively. (p = 0.047) Univariate analysis showed that BMI, stage III, age less than 64 year-old, gallbladder cancer, operation, radiotherapy and ECOG performance were significantly associated with better survival. Compared with normal patients, overweight patients (BMI 23-24.9kg/m2) had a reduced risk of mortality in multivariate analysis (HR 0.632; 95% CI 0.436-0.918, p = 0.016). In the additional analysis for the effect of changes in body weight and BMI to the overall survival, decrease in body weight and BMI (HR 1.410, 95% CI 1.168-1.986, p = 0.046) was associated with a shorter in overall survival.Overweight status and the maintenance of body weight during the initial period of chemotherapy are important and independent predictors of better overall survival in advanced biliary tract cancer patients.http://europepmc.org/articles/PMC5880377?pdf=render |
| spellingShingle | Jinwoo Kang Sang Hyub Lee Jun Hyuk Son Jae Woo Lee Young Hoon Choi Jin Ho Choi Woo Hyun Paik Ji Kon Ryu Yong-Tae Kim Body mass index and weight change during initial period of chemotherapy affect survival outcome in advanced biliary tract cancer patients. PLoS ONE |
| title | Body mass index and weight change during initial period of chemotherapy affect survival outcome in advanced biliary tract cancer patients. |
| title_full | Body mass index and weight change during initial period of chemotherapy affect survival outcome in advanced biliary tract cancer patients. |
| title_fullStr | Body mass index and weight change during initial period of chemotherapy affect survival outcome in advanced biliary tract cancer patients. |
| title_full_unstemmed | Body mass index and weight change during initial period of chemotherapy affect survival outcome in advanced biliary tract cancer patients. |
| title_short | Body mass index and weight change during initial period of chemotherapy affect survival outcome in advanced biliary tract cancer patients. |
| title_sort | body mass index and weight change during initial period of chemotherapy affect survival outcome in advanced biliary tract cancer patients |
| url | http://europepmc.org/articles/PMC5880377?pdf=render |
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