Age-dependent differences in the prognostic relevance of body composition-related variables in type A aortic dissection patients
Abstract Background The current research is allocated to appraise the association between the parameters of body composition and findings in type A aortic dissection (TAAD) cases in diverse age groups. Methods Data from consecutive TAAD patients undergoing implantation of modified triple-branched st...
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| Format: | Article |
| Language: | English |
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BMC
2021-12-01
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| Series: | Journal of Cardiothoracic Surgery |
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| Online Access: | https://doi.org/10.1186/s13019-021-01742-1 |
| _version_ | 1819095263576326144 |
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| author | Zeng-Rong Luo Xiao-Dong Chen Liang-wan Chen |
| author_facet | Zeng-Rong Luo Xiao-Dong Chen Liang-wan Chen |
| author_sort | Zeng-Rong Luo |
| collection | DOAJ |
| description | Abstract Background The current research is allocated to appraise the association between the parameters of body composition and findings in type A aortic dissection (TAAD) cases in diverse age groups. Methods Data from consecutive TAAD patients undergoing implantation of modified triple-branched stent-graft from January 2017 and December 2019 were prospectively collected and analyzed. A regression model of Cox proportional hazard was employed to assess correlations among body composition-related variables (body mass index [BMI], lean body mass [LBM], body surface area [BSA], and LBM index) as well as cumulative mortality. Results Overall, 258 patients (53.9 ± 11.1 years old; 72.9% male) were separated into young (n = 110) and elderly (n = 148) age groups based upon whether they were younger or older than 50 years of age. Of these patients, 247 survivors were included in subsequent analyses over an average 26.8 ± 11.6 month follow-up duration. Multivariate analyses in the elderly group instead of young group indicated that increased BMI (p = 0.042), BMI ≤ 18.5 kg/m2 (p = 0.025), and lower LBM index values (p = 0.019) were significant predictors of increased total all-cause cumulative mortality. BMI was considerably positively correlated with estimated all-cause cumulative mortality in elderly but not young TAAD cases. Conclusion Briefly, these results suggest that BMI and LBM indices are only significant predictors of TAAD patient all-cause mortality in elderly patient cohorts, whereas they do not offer significant prognostic value for younger patients. As such, these age differences must be taken into consideration when conducting stratified risk assessments based upon TAAD patient body composition characteristics. |
| first_indexed | 2024-12-21T23:40:31Z |
| format | Article |
| id | doaj.art-654fd4801df24c4a8460b49a8b235af2 |
| institution | Directory Open Access Journal |
| issn | 1749-8090 |
| language | English |
| last_indexed | 2024-12-21T23:40:31Z |
| publishDate | 2021-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cardiothoracic Surgery |
| spelling | doaj.art-654fd4801df24c4a8460b49a8b235af22022-12-21T18:46:15ZengBMCJournal of Cardiothoracic Surgery1749-80902021-12-0116111010.1186/s13019-021-01742-1Age-dependent differences in the prognostic relevance of body composition-related variables in type A aortic dissection patientsZeng-Rong Luo0Xiao-Dong Chen1Liang-wan Chen2Department of Cardiovascular Surgery and Cardiac Disease Center, Union Hospital, Fujian Medical UniversityDepartment of Cardiovascular Surgery and Cardiac Disease Center, Union Hospital, Fujian Medical UniversityDepartment of Cardiovascular Surgery and Cardiac Disease Center, Union Hospital, Fujian Medical UniversityAbstract Background The current research is allocated to appraise the association between the parameters of body composition and findings in type A aortic dissection (TAAD) cases in diverse age groups. Methods Data from consecutive TAAD patients undergoing implantation of modified triple-branched stent-graft from January 2017 and December 2019 were prospectively collected and analyzed. A regression model of Cox proportional hazard was employed to assess correlations among body composition-related variables (body mass index [BMI], lean body mass [LBM], body surface area [BSA], and LBM index) as well as cumulative mortality. Results Overall, 258 patients (53.9 ± 11.1 years old; 72.9% male) were separated into young (n = 110) and elderly (n = 148) age groups based upon whether they were younger or older than 50 years of age. Of these patients, 247 survivors were included in subsequent analyses over an average 26.8 ± 11.6 month follow-up duration. Multivariate analyses in the elderly group instead of young group indicated that increased BMI (p = 0.042), BMI ≤ 18.5 kg/m2 (p = 0.025), and lower LBM index values (p = 0.019) were significant predictors of increased total all-cause cumulative mortality. BMI was considerably positively correlated with estimated all-cause cumulative mortality in elderly but not young TAAD cases. Conclusion Briefly, these results suggest that BMI and LBM indices are only significant predictors of TAAD patient all-cause mortality in elderly patient cohorts, whereas they do not offer significant prognostic value for younger patients. As such, these age differences must be taken into consideration when conducting stratified risk assessments based upon TAAD patient body composition characteristics.https://doi.org/10.1186/s13019-021-01742-1Body composition parametersBMIType A aortic dissectionAge |
| spellingShingle | Zeng-Rong Luo Xiao-Dong Chen Liang-wan Chen Age-dependent differences in the prognostic relevance of body composition-related variables in type A aortic dissection patients Journal of Cardiothoracic Surgery Body composition parameters BMI Type A aortic dissection Age |
| title | Age-dependent differences in the prognostic relevance of body composition-related variables in type A aortic dissection patients |
| title_full | Age-dependent differences in the prognostic relevance of body composition-related variables in type A aortic dissection patients |
| title_fullStr | Age-dependent differences in the prognostic relevance of body composition-related variables in type A aortic dissection patients |
| title_full_unstemmed | Age-dependent differences in the prognostic relevance of body composition-related variables in type A aortic dissection patients |
| title_short | Age-dependent differences in the prognostic relevance of body composition-related variables in type A aortic dissection patients |
| title_sort | age dependent differences in the prognostic relevance of body composition related variables in type a aortic dissection patients |
| topic | Body composition parameters BMI Type A aortic dissection Age |
| url | https://doi.org/10.1186/s13019-021-01742-1 |
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