Clinical and mycological profile of fungal keratitis from North and North-East India
Purpose: To study the clinical presentation, mycological profile, and risk factors of fungal keratitis (FK) cases presenting at two tertiary-care centers, one each at North (Chandigarh) and Northeast (Assam) India, and to compare the spectrum of fungi recovered from the clinical and environmental sa...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2022;volume=70;issue=6;spage=1990;epage=1996;aulast=Tawde |
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| author | Yamini Tawde Shreya Singh Sourav Das Shivaprakash M Rudramurthy Harsimran Kaur Amit Gupta Mounjuri Kataki Pranami Gogoi Anup K Ghosh |
| author_facet | Yamini Tawde Shreya Singh Sourav Das Shivaprakash M Rudramurthy Harsimran Kaur Amit Gupta Mounjuri Kataki Pranami Gogoi Anup K Ghosh |
| author_sort | Yamini Tawde |
| collection | DOAJ |
| description | Purpose: To study the clinical presentation, mycological profile, and risk factors of fungal keratitis (FK) cases presenting at two tertiary-care centers, one each at North (Chandigarh) and Northeast (Assam) India, and to compare the spectrum of fungi recovered from the clinical and environmental samples at both locations. Methods: All patients with suspected FK were enrolled from both the centers between January 2018 and December 2019. Corneal samples were collected and processed as per standard laboratory protocols. Demographic details and clinical and mycological profiles were noted in all patients. Environmental sampling from the soil, air, and the vegetative matter was performed from both locations and neighboring districts. Results: Of the 475 suspected cases, 337 (71%) were diagnosed as FK (median age: 50 years; 77.2% males). The presence of diabetes, hypertension, blurred vision, and corneal discoloration was significantly higher in patients with FK compared to those without FK. Aspergillus sp. (52.1%) and Fusarium sp. (47.61%) were the predominant etiological agents isolated from cases in North and Northeast India, respectively. FK due to melanized fungi was associated with diabetes, trauma with animal tail, and corneal discoloration. A similar spectrum of fungi was seen in environmental and clinical samples in both the regions. Conclusion: The difference in etiological agents of FK and environmental fungal isolates in North and Northeast India highlights the need to identify the ecological niche of potential fungal pathogens. Prospective, multicenter studies, systematic environmental sampling, and the evaluation of the differences in causative agents and clinical presentation of FK from different parts of the country can substantially improve our understanding of its region-specific clinico-epidemiological profile. |
| first_indexed | 2024-04-12T14:31:30Z |
| format | Article |
| id | doaj.art-65532ddea3be416c955b01e968672172 |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-04-12T14:31:30Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-65532ddea3be416c955b01e9686721722022-12-22T03:29:16ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892022-01-017061990199610.4103/ijo.IJO_1602_21Clinical and mycological profile of fungal keratitis from North and North-East IndiaYamini TawdeShreya SinghSourav DasShivaprakash M RudramurthyHarsimran KaurAmit GuptaMounjuri KatakiPranami GogoiAnup K GhoshPurpose: To study the clinical presentation, mycological profile, and risk factors of fungal keratitis (FK) cases presenting at two tertiary-care centers, one each at North (Chandigarh) and Northeast (Assam) India, and to compare the spectrum of fungi recovered from the clinical and environmental samples at both locations. Methods: All patients with suspected FK were enrolled from both the centers between January 2018 and December 2019. Corneal samples were collected and processed as per standard laboratory protocols. Demographic details and clinical and mycological profiles were noted in all patients. Environmental sampling from the soil, air, and the vegetative matter was performed from both locations and neighboring districts. Results: Of the 475 suspected cases, 337 (71%) were diagnosed as FK (median age: 50 years; 77.2% males). The presence of diabetes, hypertension, blurred vision, and corneal discoloration was significantly higher in patients with FK compared to those without FK. Aspergillus sp. (52.1%) and Fusarium sp. (47.61%) were the predominant etiological agents isolated from cases in North and Northeast India, respectively. FK due to melanized fungi was associated with diabetes, trauma with animal tail, and corneal discoloration. A similar spectrum of fungi was seen in environmental and clinical samples in both the regions. Conclusion: The difference in etiological agents of FK and environmental fungal isolates in North and Northeast India highlights the need to identify the ecological niche of potential fungal pathogens. Prospective, multicenter studies, systematic environmental sampling, and the evaluation of the differences in causative agents and clinical presentation of FK from different parts of the country can substantially improve our understanding of its region-specific clinico-epidemiological profile.http://www.ijo.in/article.asp?issn=0301-4738;year=2022;volume=70;issue=6;spage=1990;epage=1996;aulast=Tawdeaspergillusclinical isolatesenvironmentfungal keratitisfusariumindia |
| spellingShingle | Yamini Tawde Shreya Singh Sourav Das Shivaprakash M Rudramurthy Harsimran Kaur Amit Gupta Mounjuri Kataki Pranami Gogoi Anup K Ghosh Clinical and mycological profile of fungal keratitis from North and North-East India Indian Journal of Ophthalmology aspergillus clinical isolates environment fungal keratitis fusarium india |
| title | Clinical and mycological profile of fungal keratitis from North and North-East India |
| title_full | Clinical and mycological profile of fungal keratitis from North and North-East India |
| title_fullStr | Clinical and mycological profile of fungal keratitis from North and North-East India |
| title_full_unstemmed | Clinical and mycological profile of fungal keratitis from North and North-East India |
| title_short | Clinical and mycological profile of fungal keratitis from North and North-East India |
| title_sort | clinical and mycological profile of fungal keratitis from north and north east india |
| topic | aspergillus clinical isolates environment fungal keratitis fusarium india |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2022;volume=70;issue=6;spage=1990;epage=1996;aulast=Tawde |
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