Evaluation of 2D and 3D Erythroid Differentiation Protocols Using Sickle Cell Disease and Healthy Donor Induced Pluripotent Stem Cells

Evaluation of 2D and 3D Erythroid Differentiation Protocols Using Sickle Cell Disease and Healthy Donor Induced Pluripotent Stem Cells

Background: Sickle cell disease (SCD) is a highly prevalent genetic disease caused by a point mutation in the <i>HBB</i> gene, which can lead to chronic hemolytic anemia and vaso-occlusive events. Patient-derived induced pluripotent stem cells (iPSCs) hold promise for the development of...

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Main Authors: Gabriele Louise Soares Martins, Carolina Kymie Vasques Nonaka, Erik Aranha Rossi, Adne Vitória Rocha de Lima, Corynne Stephanie Ahouefa Adanho, Moisés Santana Oliveira, Setondji Cocou Modeste Alexandre Yahouedehou, Clarissa Lima e Moura de Souza, Marilda de Souza Gonçalves, Bruno Diaz Paredes, Bruno Solano de Freitas Souza
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Cells
Subjects:
sickle cell disease
erythropoiesis
iPSCs
Online Access:https://www.mdpi.com/2073-4409/12/8/1121

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