Evaluation of Antitussive, Expectorant and Analgesic Activities of Aqueous Extracts of Di-herbal Formulation of Whole Plant of Euphobia hirta and Lactuca virosa Leaf on Rodents
Euphorbia hirta and lactuca virosa are used to treat various ailment traditionally. This study aims at evaluating the antitussive, expectorant and analgesic effects of aqueous extracts of di-herbal formulation of Euphobia hirta and Lactuca virosa leaf. Citric acid induced, ammonia induced cough and...
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| Format: | Article |
| Language: | English |
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Joint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP)
2023-09-01
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| Series: | Journal of Applied Sciences and Environmental Management |
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| Online Access: | https://www.ajol.info/index.php/jasem/article/view/254240 |
| _version_ | 1797231541988884480 |
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| author | D. O. Uwaya A. K. Bello I. Aikpitanyi |
| author_facet | D. O. Uwaya A. K. Bello I. Aikpitanyi |
| author_sort | D. O. Uwaya |
| collection | DOAJ |
| description |
Euphorbia hirta and lactuca virosa are used to treat various ailment traditionally. This study aims at evaluating the antitussive, expectorant and analgesic effects of aqueous extracts of di-herbal formulation of Euphobia hirta and Lactuca virosa leaf. Citric acid induced, ammonia induced cough and phenol red dye secretion models were used. Hot plate and acetic acid induced writhing were used for analgesia. Combined 100mg/kg Euphorbia hirta and 50mg/kg lactuca virosa, 100mg/kg Euphorbia hirta and 100mg/kg lactuca virosa, 100mg/kg lactuca virosa only and 25 mg/kg of codeine phosphate reduces the number of cough bouts in the citric acid induced cough (P<0.05) compared to control. Combined 50mg/kg Euphorbia hirta and 100mg/kg lactuca virosa,100mg/kg Euphorbia hirta, 100mg/kg lactuca virosa and codeine phosphate reduces the number of cough bouts in the ammonia induced cough (P<0.001; P<0.0001) compared to the control. Combined 50mg/kg Euphorbia hirta and 100mg/kg lactuca virosa, 100mg/kg Euphorbia hirta and 50mg/kg lactuca virosa, 100mg/kg Euphorbia hirta and 100mg/kg lactuca virosa and 15mg/kg of Bromo-hexane increases the secretion of dye (P<0.0001; p<0.05) compared to control in phenol red dye secretion in mice. 100mg/kg Euphorbia hirta and 50mg/kg lactuca virosa,100mg/kg of Euphorbia hirta and 100mg/kg lactuca virosa and 3mg/kg Pentazocin increases the latency of pain threshold of mice (P<0.05). All the doses of the extract including 3mg/kg pentazocin increases the latency to pain threshold in the mice (P<0.001) after 2 hours. All the doses of the extract including aspirin reduces number of writhing (P<0.01). Euphorbia hirta and lactuca virosa has antitussive, expectorant and analgesic properties.
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| first_indexed | 2024-04-24T15:46:02Z |
| format | Article |
| id | doaj.art-655701a9d3ac43aebeddc5d5cbec2c90 |
| institution | Directory Open Access Journal |
| issn | 2659-1502 2659-1499 |
| language | English |
| last_indexed | 2024-04-24T15:46:02Z |
| publishDate | 2023-09-01 |
| publisher | Joint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP) |
| record_format | Article |
| series | Journal of Applied Sciences and Environmental Management |
| spelling | doaj.art-655701a9d3ac43aebeddc5d5cbec2c902024-04-01T15:05:16ZengJoint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP)Journal of Applied Sciences and Environmental Management2659-15022659-14992023-09-0127810.4314/jasem.v27i8.35Evaluation of Antitussive, Expectorant and Analgesic Activities of Aqueous Extracts of Di-herbal Formulation of Whole Plant of Euphobia hirta and Lactuca virosa Leaf on RodentsD. O. UwayaA. K. BelloI. Aikpitanyi Euphorbia hirta and lactuca virosa are used to treat various ailment traditionally. This study aims at evaluating the antitussive, expectorant and analgesic effects of aqueous extracts of di-herbal formulation of Euphobia hirta and Lactuca virosa leaf. Citric acid induced, ammonia induced cough and phenol red dye secretion models were used. Hot plate and acetic acid induced writhing were used for analgesia. Combined 100mg/kg Euphorbia hirta and 50mg/kg lactuca virosa, 100mg/kg Euphorbia hirta and 100mg/kg lactuca virosa, 100mg/kg lactuca virosa only and 25 mg/kg of codeine phosphate reduces the number of cough bouts in the citric acid induced cough (P<0.05) compared to control. Combined 50mg/kg Euphorbia hirta and 100mg/kg lactuca virosa,100mg/kg Euphorbia hirta, 100mg/kg lactuca virosa and codeine phosphate reduces the number of cough bouts in the ammonia induced cough (P<0.001; P<0.0001) compared to the control. Combined 50mg/kg Euphorbia hirta and 100mg/kg lactuca virosa, 100mg/kg Euphorbia hirta and 50mg/kg lactuca virosa, 100mg/kg Euphorbia hirta and 100mg/kg lactuca virosa and 15mg/kg of Bromo-hexane increases the secretion of dye (P<0.0001; p<0.05) compared to control in phenol red dye secretion in mice. 100mg/kg Euphorbia hirta and 50mg/kg lactuca virosa,100mg/kg of Euphorbia hirta and 100mg/kg lactuca virosa and 3mg/kg Pentazocin increases the latency of pain threshold of mice (P<0.05). All the doses of the extract including 3mg/kg pentazocin increases the latency to pain threshold in the mice (P<0.001) after 2 hours. All the doses of the extract including aspirin reduces number of writhing (P<0.01). Euphorbia hirta and lactuca virosa has antitussive, expectorant and analgesic properties. https://www.ajol.info/index.php/jasem/article/view/254240Euphorbia hirta;lactuca virosa;anti-tussive;analgesic;inflammation |
| spellingShingle | D. O. Uwaya A. K. Bello I. Aikpitanyi Evaluation of Antitussive, Expectorant and Analgesic Activities of Aqueous Extracts of Di-herbal Formulation of Whole Plant of Euphobia hirta and Lactuca virosa Leaf on Rodents Journal of Applied Sciences and Environmental Management Euphorbia hirta; lactuca virosa; anti-tussive; analgesic; inflammation |
| title | Evaluation of Antitussive, Expectorant and Analgesic Activities of Aqueous Extracts of Di-herbal Formulation of Whole Plant of Euphobia hirta and Lactuca virosa Leaf on Rodents |
| title_full | Evaluation of Antitussive, Expectorant and Analgesic Activities of Aqueous Extracts of Di-herbal Formulation of Whole Plant of Euphobia hirta and Lactuca virosa Leaf on Rodents |
| title_fullStr | Evaluation of Antitussive, Expectorant and Analgesic Activities of Aqueous Extracts of Di-herbal Formulation of Whole Plant of Euphobia hirta and Lactuca virosa Leaf on Rodents |
| title_full_unstemmed | Evaluation of Antitussive, Expectorant and Analgesic Activities of Aqueous Extracts of Di-herbal Formulation of Whole Plant of Euphobia hirta and Lactuca virosa Leaf on Rodents |
| title_short | Evaluation of Antitussive, Expectorant and Analgesic Activities of Aqueous Extracts of Di-herbal Formulation of Whole Plant of Euphobia hirta and Lactuca virosa Leaf on Rodents |
| title_sort | evaluation of antitussive expectorant and analgesic activities of aqueous extracts of di herbal formulation of whole plant of euphobia hirta and lactuca virosa leaf on rodents |
| topic | Euphorbia hirta; lactuca virosa; anti-tussive; analgesic; inflammation |
| url | https://www.ajol.info/index.php/jasem/article/view/254240 |
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