Anti-inflammatory Effects of Quercetin and Vitexin on Activated Human Peripheral Blood Neutrophils - The effects of quercetin and vitexin on human neutrophils -
Objectives: Polymorphonuclear neutrophils (PMNs) constitute the first line of defense against invading microbial pathogens. Early events in inflammation involve the recruitment of neutrophils to the site of injury or damage where changes in intracellular calcium can cause the activation of pro-infla...
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| Format: | Article |
| Language: | English |
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Korean Pharmacopuncture Institute
2017-06-01
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| Series: | Journal of Pharmacopuncture |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3831/KPI.2017.20.017 |
| _version_ | 1818505924359225344 |
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| author | Bahareh Abd Nikfarjam Farid Hajiali Mohtaram Adineh Marjan Nassiri-Asl |
| author_facet | Bahareh Abd Nikfarjam Farid Hajiali Mohtaram Adineh Marjan Nassiri-Asl |
| author_sort | Bahareh Abd Nikfarjam |
| collection | DOAJ |
| description | Objectives: Polymorphonuclear neutrophils (PMNs) constitute the first line of defense against invading microbial pathogens. Early events in inflammation involve the recruitment of neutrophils to the site of injury or damage where changes in intracellular calcium can cause the activation of pro-inflammatory mediators from neutrophils including superoxide generation, degranulation and release of myeloperoxidase (MPO), productions of interleukin (IL)-8 and tumor necrosis factor α (TNF-α), and adhesion to the vascular endothelium. To address the anti-inflammatory role of flavonoids, in the present study, we investigated the effects of the flavonoids quercetin and vitexin on the stimulus-induced nitric oxide (NO), TNF-α, and MPO productions in human neutrophils. Methods: Human peripheral blood neutrophils were isolated, and their viabilities were determined by using the Trypan Blue exclusion test. The polymorphonuclear leukocyte (PMNL) preparations contained more than 98% neutrophils as determin |
| first_indexed | 2024-12-10T21:57:28Z |
| format | Article |
| id | doaj.art-655941cdc39144aa98495c00e56ff05c |
| institution | Directory Open Access Journal |
| issn | 2093-6966 2234-6856 |
| language | English |
| last_indexed | 2024-12-10T21:57:28Z |
| publishDate | 2017-06-01 |
| publisher | Korean Pharmacopuncture Institute |
| record_format | Article |
| series | Journal of Pharmacopuncture |
| spelling | doaj.art-655941cdc39144aa98495c00e56ff05c2022-12-22T01:32:00ZengKorean Pharmacopuncture InstituteJournal of Pharmacopuncture2093-69662234-68562017-06-0120212713110.3831/KPI.2017.20.017DHOCBS_2017_v20n2_127Anti-inflammatory Effects of Quercetin and Vitexin on Activated Human Peripheral Blood Neutrophils - The effects of quercetin and vitexin on human neutrophils -Bahareh Abd Nikfarjam0Farid Hajiali1Mohtaram Adineh2Marjan Nassiri-Asl3Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, IranCellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, IranDepartment of Immunology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, IranCellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, IranObjectives: Polymorphonuclear neutrophils (PMNs) constitute the first line of defense against invading microbial pathogens. Early events in inflammation involve the recruitment of neutrophils to the site of injury or damage where changes in intracellular calcium can cause the activation of pro-inflammatory mediators from neutrophils including superoxide generation, degranulation and release of myeloperoxidase (MPO), productions of interleukin (IL)-8 and tumor necrosis factor α (TNF-α), and adhesion to the vascular endothelium. To address the anti-inflammatory role of flavonoids, in the present study, we investigated the effects of the flavonoids quercetin and vitexin on the stimulus-induced nitric oxide (NO), TNF-α, and MPO productions in human neutrophils. Methods: Human peripheral blood neutrophils were isolated, and their viabilities were determined by using the Trypan Blue exclusion test. The polymorphonuclear leukocyte (PMNL) preparations contained more than 98% neutrophils as determinhttp://dx.doi.org/10.3831/KPI.2017.20.017human neutrophilsmyeloperoxidasenitric oxidequercetintumor necrosis factor-αvitexin |
| spellingShingle | Bahareh Abd Nikfarjam Farid Hajiali Mohtaram Adineh Marjan Nassiri-Asl Anti-inflammatory Effects of Quercetin and Vitexin on Activated Human Peripheral Blood Neutrophils - The effects of quercetin and vitexin on human neutrophils - Journal of Pharmacopuncture human neutrophils myeloperoxidase nitric oxide quercetin tumor necrosis factor-α vitexin |
| title | Anti-inflammatory Effects of Quercetin and Vitexin on Activated Human Peripheral Blood Neutrophils - The effects of quercetin and vitexin on human neutrophils - |
| title_full | Anti-inflammatory Effects of Quercetin and Vitexin on Activated Human Peripheral Blood Neutrophils - The effects of quercetin and vitexin on human neutrophils - |
| title_fullStr | Anti-inflammatory Effects of Quercetin and Vitexin on Activated Human Peripheral Blood Neutrophils - The effects of quercetin and vitexin on human neutrophils - |
| title_full_unstemmed | Anti-inflammatory Effects of Quercetin and Vitexin on Activated Human Peripheral Blood Neutrophils - The effects of quercetin and vitexin on human neutrophils - |
| title_short | Anti-inflammatory Effects of Quercetin and Vitexin on Activated Human Peripheral Blood Neutrophils - The effects of quercetin and vitexin on human neutrophils - |
| title_sort | anti inflammatory effects of quercetin and vitexin on activated human peripheral blood neutrophils the effects of quercetin and vitexin on human neutrophils |
| topic | human neutrophils myeloperoxidase nitric oxide quercetin tumor necrosis factor-α vitexin |
| url | http://dx.doi.org/10.3831/KPI.2017.20.017 |
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