Absence of cytotoxic and inflammatory effects following in vitro exposure of chondrogenically-differentiated human mesenchymal stem cells to adenosine, lidocaine and Mg2+ solution

Absence of cytotoxic and inflammatory effects following in vitro exposure of chondrogenically-differentiated human mesenchymal stem cells to adenosine, lidocaine and Mg2+ solution

Abstract Background ALM solution, a combination of adenosine, lidocaine and Mg2+, is an emerging small volume therapy that has been shown to prevent and correct coagulopathy and surgery-related inflammation in preclinical models, though its application in orthopaedic surgery is yet to be demonstrate...

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Bibliographic Details
Main Authors: Andrew McCutchan, Geoffrey P. Dobson, Natalie Stewart, Hayley L. Letson, Andrea L. Grant, Ivana-Aleksandra Jovanovic, Kaushik Hazratwala, Matthew Wilkinson, Peter McEwen, Jodie Morris
Format: Article
Language:English
Published: Wiley 2019-04-01
Series:Journal of Experimental Orthopaedics
Subjects:
Chondro-MSC
Chondrocyte
ALM
Tranexamic acid
Viability
Inflammation
Online Access:http://link.springer.com/article/10.1186/s40634-019-0185-5

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