A Comprehensive Review of COVID-19-Infection- and Steroid-Treatment-Associated Bone Avascular Necrosis: A Multi-Study Analysis
Background: The COVID-19 pandemic has presented numerous challenges to the global healthcare system and emerging evidence suggests a potential link between COVID-19 treatment, specifically steroid therapy, and the development of avascular necrosis (AVN) of the hip. This review aims to provide a comp...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/14/3/247 |
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| author | Evangelos Sakellariou Evangelia Argyropoulou Panagiotis Karampinas Athanasios Galanis Iordanis Varsamos Vasileios Giannatos Elias Vasiliadis Angelos Kaspiris John Vlamis Spiros Pneumaticos |
| author_facet | Evangelos Sakellariou Evangelia Argyropoulou Panagiotis Karampinas Athanasios Galanis Iordanis Varsamos Vasileios Giannatos Elias Vasiliadis Angelos Kaspiris John Vlamis Spiros Pneumaticos |
| author_sort | Evangelos Sakellariou |
| collection | DOAJ |
| description | Background: The COVID-19 pandemic has presented numerous challenges to the global healthcare system and emerging evidence suggests a potential link between COVID-19 treatment, specifically steroid therapy, and the development of avascular necrosis (AVN) of the hip. This review aims to provide a comprehensive overview of recent studies and case reports investigating the relationship between COVID-19, corticosteroid therapy, and the development of AVN. Understanding the nuances of AVN in the context of COVID-19 is crucial for healthcare professionals to navigate treatment decisions and mitigate potential complications. Materials and Methods: The Preferred Reporting Items for Systematic Reviews and a Meta-Analysis (PRISMA) were used in the systematic review until 1 September 2023. The full texts of the remaining twenty-three (<i>n</i> = 23) articles were independently reviewed by the authors of this review. Conclusions: The association between steroid therapy for COVID-19 and the development of hip AVN is a noteworthy concern even though no relationship is evident between the duration of treatment, cumulative dosage of medication, maximum daily dosage received, and presence of AVN. Further research with larger cohorts and long-term follow up is needed to better understand the causative relationship and optimal management strategies for hip AVN in the context of COVID-19 and steroid therapy. |
| first_indexed | 2024-03-08T03:59:34Z |
| format | Article |
| id | doaj.art-6559ff0f0bfb4d4ea747aecab302b7b8 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-08T03:59:34Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-6559ff0f0bfb4d4ea747aecab302b7b82024-02-09T15:09:57ZengMDPI AGDiagnostics2075-44182024-01-0114324710.3390/diagnostics14030247A Comprehensive Review of COVID-19-Infection- and Steroid-Treatment-Associated Bone Avascular Necrosis: A Multi-Study AnalysisEvangelos Sakellariou0Evangelia Argyropoulou1Panagiotis Karampinas2Athanasios Galanis3Iordanis Varsamos4Vasileios Giannatos5Elias Vasiliadis6Angelos Kaspiris7John Vlamis8Spiros Pneumaticos9Department of Orthopaedic Surgery, National & Kapodistrian University of Athens, KAT General Hospital, 14561 Athens, GreeceDepartment of Orthopaedics and Traumatology, University General Hospital of Patras, 26504 Patras, GreeceDepartment of Orthopaedic Surgery, National & Kapodistrian University of Athens, KAT General Hospital, 14561 Athens, GreeceDepartment of Orthopaedic Surgery, National & Kapodistrian University of Athens, KAT General Hospital, 14561 Athens, GreeceDepartment of Orthopaedic Surgery, National & Kapodistrian University of Athens, KAT General Hospital, 14561 Athens, GreeceDepartment of Orthopaedics and Traumatology, University General Hospital of Patras, 26504 Patras, GreeceDepartment of Orthopaedic Surgery, National & Kapodistrian University of Athens, KAT General Hospital, 14561 Athens, GreeceDepartment of Orthopaedic Surgery, National & Kapodistrian University of Athens, KAT General Hospital, 14561 Athens, GreeceDepartment of Orthopaedic Surgery, National & Kapodistrian University of Athens, KAT General Hospital, 14561 Athens, GreeceDepartment of Orthopaedic Surgery, National & Kapodistrian University of Athens, KAT General Hospital, 14561 Athens, GreeceBackground: The COVID-19 pandemic has presented numerous challenges to the global healthcare system and emerging evidence suggests a potential link between COVID-19 treatment, specifically steroid therapy, and the development of avascular necrosis (AVN) of the hip. This review aims to provide a comprehensive overview of recent studies and case reports investigating the relationship between COVID-19, corticosteroid therapy, and the development of AVN. Understanding the nuances of AVN in the context of COVID-19 is crucial for healthcare professionals to navigate treatment decisions and mitigate potential complications. Materials and Methods: The Preferred Reporting Items for Systematic Reviews and a Meta-Analysis (PRISMA) were used in the systematic review until 1 September 2023. The full texts of the remaining twenty-three (<i>n</i> = 23) articles were independently reviewed by the authors of this review. Conclusions: The association between steroid therapy for COVID-19 and the development of hip AVN is a noteworthy concern even though no relationship is evident between the duration of treatment, cumulative dosage of medication, maximum daily dosage received, and presence of AVN. Further research with larger cohorts and long-term follow up is needed to better understand the causative relationship and optimal management strategies for hip AVN in the context of COVID-19 and steroid therapy.https://www.mdpi.com/2075-4418/14/3/247COVID-19AVNbone avascular necrosisosteonecrosiship painsteroids |
| spellingShingle | Evangelos Sakellariou Evangelia Argyropoulou Panagiotis Karampinas Athanasios Galanis Iordanis Varsamos Vasileios Giannatos Elias Vasiliadis Angelos Kaspiris John Vlamis Spiros Pneumaticos A Comprehensive Review of COVID-19-Infection- and Steroid-Treatment-Associated Bone Avascular Necrosis: A Multi-Study Analysis Diagnostics COVID-19 AVN bone avascular necrosis osteonecrosis hip pain steroids |
| title | A Comprehensive Review of COVID-19-Infection- and Steroid-Treatment-Associated Bone Avascular Necrosis: A Multi-Study Analysis |
| title_full | A Comprehensive Review of COVID-19-Infection- and Steroid-Treatment-Associated Bone Avascular Necrosis: A Multi-Study Analysis |
| title_fullStr | A Comprehensive Review of COVID-19-Infection- and Steroid-Treatment-Associated Bone Avascular Necrosis: A Multi-Study Analysis |
| title_full_unstemmed | A Comprehensive Review of COVID-19-Infection- and Steroid-Treatment-Associated Bone Avascular Necrosis: A Multi-Study Analysis |
| title_short | A Comprehensive Review of COVID-19-Infection- and Steroid-Treatment-Associated Bone Avascular Necrosis: A Multi-Study Analysis |
| title_sort | comprehensive review of covid 19 infection and steroid treatment associated bone avascular necrosis a multi study analysis |
| topic | COVID-19 AVN bone avascular necrosis osteonecrosis hip pain steroids |
| url | https://www.mdpi.com/2075-4418/14/3/247 |
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