Astragaloside IV protects diabetic cardiomyopathy against inflammation and apoptosis via regulating TLR4/MyD88/NF-κB signaling pathway

Astragaloside IV protects diabetic cardiomyopathy against inflammation and apoptosis via regulating TLR4/MyD88/NF-κB signaling pathway

Inflammatory response-mediated excessive apoptosis is the main pathological alteration in the development of diabetic cardiomyopathy (DCM). The role of astragaloside IV (AS-IV) in the treatment of DCM is still unclear. In vivo model was established by high-fat diet plus 1% STZ, and in vitro model wa...

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Bibliographic Details
Main Authors: Liang Wang, Hui Shi, Chun-chun Zhao, Jing-ya Li, Jian-fei Peng, An-lu Shen, Peng Zhou, Hui-min Bian
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Journal of Functional Foods
Subjects:
Diabetic cardiomyopathy
Astragaloside IV
TLR4/MyD88/NF-κB signaling pathway
Inflammation
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464621005545

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