Spermidine Rescues Bioenergetic and Mitophagy Deficits Induced by Disease-Associated Tau Protein

Spermidine Rescues Bioenergetic and Mitophagy Deficits Induced by Disease-Associated Tau Protein

Abnormal tau build-up is a hallmark of Alzheimer’s disease (AD) and more than 20 other serious neurodegenerative diseases. Mitochondria are paramount organelles playing a predominant role in cellular bioenergetics, namely by providing the main source of cellular energy via adenosine triphosphate gen...

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Bibliographic Details
Main Authors: Lauren H. Fairley, Imane Lejri, Amandine Grimm, Anne Eckert
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
tau
mitochondria
spermidine
bioenergetics
autophagy
mitophagy
Online Access:https://www.mdpi.com/1422-0067/24/6/5297

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