The Influence of Tramadol on Intravaginal Ejaculatory Latency Time and Sexual Satisfaction Score in Treating Patients With Premature Ejaculation: A Network Meta-Analysis
This network meta-analysis aimed at assessing the influence of tramadol on the intravaginal ejaculatory latency time (IELT) and sexual satisfaction score (SSS) in treating patients with premature ejaculation (PE). The PubMed, Embase, Cochrane Library databases (until July 2021), and original referen...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2021-11-01
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| Series: | American Journal of Men's Health |
| Online Access: | https://doi.org/10.1177/15579883211057713 |
| _version_ | 1819103473344446464 |
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| author | Youyi Lu MD Zhongbao Zhou MD Xiaoyi Zhang MD Yuanshan Cui MD Yong Zhang MD Yongqiang Wang MD |
| author_facet | Youyi Lu MD Zhongbao Zhou MD Xiaoyi Zhang MD Yuanshan Cui MD Yong Zhang MD Yongqiang Wang MD |
| author_sort | Youyi Lu MD |
| collection | DOAJ |
| description | This network meta-analysis aimed at assessing the influence of tramadol on the intravaginal ejaculatory latency time (IELT) and sexual satisfaction score (SSS) in treating patients with premature ejaculation (PE). The PubMed, Embase, Cochrane Library databases (until July 2021), and original references of the included articles was systematically retrieved. The PRISMA checklist was followed. Finally, 14 articles including 1971 patients were included in this analysis. The results indicated that patients who were treated with tramadol (50 mg, 62 mg, 89 mg, and 100 mg) were superior to those treated with placebo in terms of IELT ( p = .003, p < .00001, p < .00001, and p < .00001, respectively), but 25 mg tramadol did not show a significant advantage ( p = .06). Patients who were treated with tramadol (50 mg and 100 mg) had a better efficacy than who were treated with 25 mg tramadol in the IELT ( p < .00001 and p < .00001), but the effect of 50 mg tramadol and 100 mg tramadol were not significantly different ( p = .17). The tramadol group had the better effect than the placebo group in the SSS ( p < .0001). And 50 mg tramadol showed a significant improvement compared with 20 mg paroxetine, as assessed by the IELT ( p = .03) and SSS ( p = .03). Safety assessments including adverse events suggested that tramadol was well tolerated. Tramadol showed a better improvement of IELT and SSS than placebo or paroxetine, and 50 mg tramadol may be a more reasonable therapeutic dose for patients with PE. |
| first_indexed | 2024-12-22T01:51:01Z |
| format | Article |
| id | doaj.art-655f59c6971340f3893b3da2d94883d3 |
| institution | Directory Open Access Journal |
| issn | 1557-9891 |
| language | English |
| last_indexed | 2024-12-22T01:51:01Z |
| publishDate | 2021-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | American Journal of Men's Health |
| spelling | doaj.art-655f59c6971340f3893b3da2d94883d32022-12-21T18:42:55ZengSAGE PublishingAmerican Journal of Men's Health1557-98912021-11-011510.1177/15579883211057713The Influence of Tramadol on Intravaginal Ejaculatory Latency Time and Sexual Satisfaction Score in Treating Patients With Premature Ejaculation: A Network Meta-AnalysisYouyi Lu MD0Zhongbao Zhou MD1Xiaoyi Zhang MD2Yuanshan Cui MD3Yong Zhang MD4Yongqiang Wang MD5Department of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, ChinaDepartment of Urology, Beijing TianTan Hospital, Capital Medical University, Fengtai District, Beijing, ChinaDepartment of Urology, PLA Rocket Force Characteristic Medical Center, Xicheng District, Beijing, ChinaDepartment of Urology, Beijing TianTan Hospital, Capital Medical University, Fengtai District, Beijing, ChinaDepartment of Urology, Beijing TianTan Hospital, Capital Medical University, Fengtai District, Beijing, ChinaDepartment of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, ChinaThis network meta-analysis aimed at assessing the influence of tramadol on the intravaginal ejaculatory latency time (IELT) and sexual satisfaction score (SSS) in treating patients with premature ejaculation (PE). The PubMed, Embase, Cochrane Library databases (until July 2021), and original references of the included articles was systematically retrieved. The PRISMA checklist was followed. Finally, 14 articles including 1971 patients were included in this analysis. The results indicated that patients who were treated with tramadol (50 mg, 62 mg, 89 mg, and 100 mg) were superior to those treated with placebo in terms of IELT ( p = .003, p < .00001, p < .00001, and p < .00001, respectively), but 25 mg tramadol did not show a significant advantage ( p = .06). Patients who were treated with tramadol (50 mg and 100 mg) had a better efficacy than who were treated with 25 mg tramadol in the IELT ( p < .00001 and p < .00001), but the effect of 50 mg tramadol and 100 mg tramadol were not significantly different ( p = .17). The tramadol group had the better effect than the placebo group in the SSS ( p < .0001). And 50 mg tramadol showed a significant improvement compared with 20 mg paroxetine, as assessed by the IELT ( p = .03) and SSS ( p = .03). Safety assessments including adverse events suggested that tramadol was well tolerated. Tramadol showed a better improvement of IELT and SSS than placebo or paroxetine, and 50 mg tramadol may be a more reasonable therapeutic dose for patients with PE.https://doi.org/10.1177/15579883211057713 |
| spellingShingle | Youyi Lu MD Zhongbao Zhou MD Xiaoyi Zhang MD Yuanshan Cui MD Yong Zhang MD Yongqiang Wang MD The Influence of Tramadol on Intravaginal Ejaculatory Latency Time and Sexual Satisfaction Score in Treating Patients With Premature Ejaculation: A Network Meta-Analysis American Journal of Men's Health |
| title | The Influence of Tramadol on Intravaginal Ejaculatory Latency Time and Sexual Satisfaction Score in Treating Patients With Premature Ejaculation: A Network Meta-Analysis |
| title_full | The Influence of Tramadol on Intravaginal Ejaculatory Latency Time and Sexual Satisfaction Score in Treating Patients With Premature Ejaculation: A Network Meta-Analysis |
| title_fullStr | The Influence of Tramadol on Intravaginal Ejaculatory Latency Time and Sexual Satisfaction Score in Treating Patients With Premature Ejaculation: A Network Meta-Analysis |
| title_full_unstemmed | The Influence of Tramadol on Intravaginal Ejaculatory Latency Time and Sexual Satisfaction Score in Treating Patients With Premature Ejaculation: A Network Meta-Analysis |
| title_short | The Influence of Tramadol on Intravaginal Ejaculatory Latency Time and Sexual Satisfaction Score in Treating Patients With Premature Ejaculation: A Network Meta-Analysis |
| title_sort | influence of tramadol on intravaginal ejaculatory latency time and sexual satisfaction score in treating patients with premature ejaculation a network meta analysis |
| url | https://doi.org/10.1177/15579883211057713 |
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