The Clinical Features and Prognostic Factors for Treatment Outcomes of Dematiaceous Fungal Keratitis over 9 Years at a Tertiary Eye Care in Northern Thailand
Dematiaceous fungal keratitis is an important etiology of visual loss, particularly in an agricultural society. From a retrospective review of medical records from 2012 to 2020, 50 keratitis cases of cultured-positive for dematiaceous fungi were presented at a tertiary care hospital in Northern Thai...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-06-01
|
| Series: | Journal of Fungi |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2309-608X/7/7/526 |
| _version_ | 1827688436165771264 |
|---|---|
| author | Chulaluck Tangmonkongvoragul Susama Chokesuwattanaskul Napaporn Tananuvat Monsicha Pongpom Phit Upaphong Sinthirath Saysithidej Muanploy Niparugs Siriporn Chongkae |
| author_facet | Chulaluck Tangmonkongvoragul Susama Chokesuwattanaskul Napaporn Tananuvat Monsicha Pongpom Phit Upaphong Sinthirath Saysithidej Muanploy Niparugs Siriporn Chongkae |
| author_sort | Chulaluck Tangmonkongvoragul |
| collection | DOAJ |
| description | Dematiaceous fungal keratitis is an important etiology of visual loss, particularly in an agricultural society. From a retrospective review of medical records from 2012 to 2020, 50 keratitis cases of cultured-positive for dematiaceous fungi were presented at a tertiary care hospital in Northern Thailand. The study aimed to identify the isolated causative dematiaceous species using the PCR technique and to explore their related clinical features, including treatment prognoses. Sequencing of the amplified D1/D2 domains and/or ITS region were applied and sequenced. Of the 50 dematiaceous fungal keratitis cases, 41 patients were males (82%). In most cases, the onset happened during the monsoon season (June to September) (48%). The majority of the patients (72%) had a history of ocular trauma from an organic foreign body. The most common species identified were <i>Lasiodiplodia</i> spp. (19.35%), followed by <i>Cladosporium</i> spp. and <i>Curvularia</i> spp. (12.90% each). About half of the patients (52%) were in the medical failure group where surgical intervention was required. In summary, ocular trauma from an organic foreign body was the major risk factor of dematiaceous fungal keratitis in Northern Thailand. The brown pigmentation could be observed in only 26%. Significant prognostic factors for medical failure were visual acuity at presentation, area of infiltrate, depth of the lesions, and hypopyon. |
| first_indexed | 2024-03-10T09:55:43Z |
| format | Article |
| id | doaj.art-6560c481f7d14eb7a67c5069f74e8ffd |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-10T09:55:43Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-6560c481f7d14eb7a67c5069f74e8ffd2023-11-22T02:21:28ZengMDPI AGJournal of Fungi2309-608X2021-06-017752610.3390/jof7070526The Clinical Features and Prognostic Factors for Treatment Outcomes of Dematiaceous Fungal Keratitis over 9 Years at a Tertiary Eye Care in Northern ThailandChulaluck Tangmonkongvoragul0Susama Chokesuwattanaskul1Napaporn Tananuvat2Monsicha Pongpom3Phit Upaphong4Sinthirath Saysithidej5Muanploy Niparugs6Siriporn Chongkae7Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandNational Ophthalmology Center, Vientiane 0100, LaosDepartment of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandDematiaceous fungal keratitis is an important etiology of visual loss, particularly in an agricultural society. From a retrospective review of medical records from 2012 to 2020, 50 keratitis cases of cultured-positive for dematiaceous fungi were presented at a tertiary care hospital in Northern Thailand. The study aimed to identify the isolated causative dematiaceous species using the PCR technique and to explore their related clinical features, including treatment prognoses. Sequencing of the amplified D1/D2 domains and/or ITS region were applied and sequenced. Of the 50 dematiaceous fungal keratitis cases, 41 patients were males (82%). In most cases, the onset happened during the monsoon season (June to September) (48%). The majority of the patients (72%) had a history of ocular trauma from an organic foreign body. The most common species identified were <i>Lasiodiplodia</i> spp. (19.35%), followed by <i>Cladosporium</i> spp. and <i>Curvularia</i> spp. (12.90% each). About half of the patients (52%) were in the medical failure group where surgical intervention was required. In summary, ocular trauma from an organic foreign body was the major risk factor of dematiaceous fungal keratitis in Northern Thailand. The brown pigmentation could be observed in only 26%. Significant prognostic factors for medical failure were visual acuity at presentation, area of infiltrate, depth of the lesions, and hypopyon.https://www.mdpi.com/2309-608X/7/7/526dematiaceous fungifungal keratitisPCRprognostic factor |
| spellingShingle | Chulaluck Tangmonkongvoragul Susama Chokesuwattanaskul Napaporn Tananuvat Monsicha Pongpom Phit Upaphong Sinthirath Saysithidej Muanploy Niparugs Siriporn Chongkae The Clinical Features and Prognostic Factors for Treatment Outcomes of Dematiaceous Fungal Keratitis over 9 Years at a Tertiary Eye Care in Northern Thailand Journal of Fungi dematiaceous fungi fungal keratitis PCR prognostic factor |
| title | The Clinical Features and Prognostic Factors for Treatment Outcomes of Dematiaceous Fungal Keratitis over 9 Years at a Tertiary Eye Care in Northern Thailand |
| title_full | The Clinical Features and Prognostic Factors for Treatment Outcomes of Dematiaceous Fungal Keratitis over 9 Years at a Tertiary Eye Care in Northern Thailand |
| title_fullStr | The Clinical Features and Prognostic Factors for Treatment Outcomes of Dematiaceous Fungal Keratitis over 9 Years at a Tertiary Eye Care in Northern Thailand |
| title_full_unstemmed | The Clinical Features and Prognostic Factors for Treatment Outcomes of Dematiaceous Fungal Keratitis over 9 Years at a Tertiary Eye Care in Northern Thailand |
| title_short | The Clinical Features and Prognostic Factors for Treatment Outcomes of Dematiaceous Fungal Keratitis over 9 Years at a Tertiary Eye Care in Northern Thailand |
| title_sort | clinical features and prognostic factors for treatment outcomes of dematiaceous fungal keratitis over 9 years at a tertiary eye care in northern thailand |
| topic | dematiaceous fungi fungal keratitis PCR prognostic factor |
| url | https://www.mdpi.com/2309-608X/7/7/526 |
| work_keys_str_mv | AT chulalucktangmonkongvoragul theclinicalfeaturesandprognosticfactorsfortreatmentoutcomesofdematiaceousfungalkeratitisover9yearsatatertiaryeyecareinnorthernthailand AT susamachokesuwattanaskul theclinicalfeaturesandprognosticfactorsfortreatmentoutcomesofdematiaceousfungalkeratitisover9yearsatatertiaryeyecareinnorthernthailand AT napaporntananuvat theclinicalfeaturesandprognosticfactorsfortreatmentoutcomesofdematiaceousfungalkeratitisover9yearsatatertiaryeyecareinnorthernthailand AT monsichapongpom theclinicalfeaturesandprognosticfactorsfortreatmentoutcomesofdematiaceousfungalkeratitisover9yearsatatertiaryeyecareinnorthernthailand AT phitupaphong theclinicalfeaturesandprognosticfactorsfortreatmentoutcomesofdematiaceousfungalkeratitisover9yearsatatertiaryeyecareinnorthernthailand AT sinthirathsaysithidej theclinicalfeaturesandprognosticfactorsfortreatmentoutcomesofdematiaceousfungalkeratitisover9yearsatatertiaryeyecareinnorthernthailand AT muanployniparugs theclinicalfeaturesandprognosticfactorsfortreatmentoutcomesofdematiaceousfungalkeratitisover9yearsatatertiaryeyecareinnorthernthailand AT siripornchongkae theclinicalfeaturesandprognosticfactorsfortreatmentoutcomesofdematiaceousfungalkeratitisover9yearsatatertiaryeyecareinnorthernthailand AT chulalucktangmonkongvoragul clinicalfeaturesandprognosticfactorsfortreatmentoutcomesofdematiaceousfungalkeratitisover9yearsatatertiaryeyecareinnorthernthailand AT susamachokesuwattanaskul clinicalfeaturesandprognosticfactorsfortreatmentoutcomesofdematiaceousfungalkeratitisover9yearsatatertiaryeyecareinnorthernthailand AT napaporntananuvat clinicalfeaturesandprognosticfactorsfortreatmentoutcomesofdematiaceousfungalkeratitisover9yearsatatertiaryeyecareinnorthernthailand AT monsichapongpom clinicalfeaturesandprognosticfactorsfortreatmentoutcomesofdematiaceousfungalkeratitisover9yearsatatertiaryeyecareinnorthernthailand AT phitupaphong clinicalfeaturesandprognosticfactorsfortreatmentoutcomesofdematiaceousfungalkeratitisover9yearsatatertiaryeyecareinnorthernthailand AT sinthirathsaysithidej clinicalfeaturesandprognosticfactorsfortreatmentoutcomesofdematiaceousfungalkeratitisover9yearsatatertiaryeyecareinnorthernthailand AT muanployniparugs clinicalfeaturesandprognosticfactorsfortreatmentoutcomesofdematiaceousfungalkeratitisover9yearsatatertiaryeyecareinnorthernthailand AT siripornchongkae clinicalfeaturesandprognosticfactorsfortreatmentoutcomesofdematiaceousfungalkeratitisover9yearsatatertiaryeyecareinnorthernthailand |