Fine mapping and functional analysis of the multiple sclerosis risk gene CD6.

Fine mapping and functional analysis of the multiple sclerosis risk gene CD6.

CD6 has recently been identified and validated as risk gene for multiple sclerosis (MS), based on the association of a single nucleotide polymorphism (SNP), rs17824933, located in intron 1. CD6 is a cell surface scavenger receptor involved in T-cell activation and proliferation, as well as in thymoc...

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Main Authors: Bhairavi Swaminathan, Angélica Cuapio, Iraide Alloza, Fuencisla Matesanz, Antonio Alcina, Maria García-Barcina, Maria Fedetz, Oscar Fernández, Miguel Lucas, Teresa Orpez, M Jesus Pinto-Medel, David Otaegui, Javier Olascoaga, Elena Urcelay, Miguel A Ortiz, Rafael Arroyo, Jorge R Oksenberg, Alfredo Antigüedad, Eva Tolosa, Koen Vandenbroeck
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3634811?pdf=render

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