Preoperative FMRI associated with decreased mortality and morbidity in brain tumor patients
Background: Functional Magnetic Resonance Imaging (fMRI) is a presurgical planning technique used to localize functional cortex so as to maximize resection of diseased tissue and avoid viable tissue. In this retrospective study, we examined differences in morbidity and mortality of brain tumor patie...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-09-01
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| Series: | Interdisciplinary Neurosurgery |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214751917302293 |
| _version_ | 1798043631063400448 |
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| author | S. Vysotski C. Madura B. Swan R. Holdsworth Y. Lin A. Munoz Del Rio J. Wood B. Kundu A. Penwarden J. Voss T. Gallagher V.A. Nair A. Field C. Garcia-Ramos M.E. Meyerand M. Baskaya V. Prabhakaran J.S. Kuo |
| author_facet | S. Vysotski C. Madura B. Swan R. Holdsworth Y. Lin A. Munoz Del Rio J. Wood B. Kundu A. Penwarden J. Voss T. Gallagher V.A. Nair A. Field C. Garcia-Ramos M.E. Meyerand M. Baskaya V. Prabhakaran J.S. Kuo |
| author_sort | S. Vysotski |
| collection | DOAJ |
| description | Background: Functional Magnetic Resonance Imaging (fMRI) is a presurgical planning technique used to localize functional cortex so as to maximize resection of diseased tissue and avoid viable tissue. In this retrospective study, we examined differences in morbidity and mortality of brain tumor patients who received preoperative fMRI in comparison to those who did not. Methods: Brain tumor patients (n = 206) were selected from a retrospective review of neurosurgical case logs from 2001 to 2009 at the University of Wisconsin-Madison. Results: Univariate analysis showed improved mortality in the fMRI group and the fMRI + Electrical Cortical Stimulation Mapping (ECM) group compared to the No-fMRI group. Multivariate analyses showed improved mortality of the fMRI group and the fMRI + ECM group compared to the No-fMRI group, with age and tumor grade being the most significant influencers. Overall, the fMRI group showed survival benefits at 3 years; twice that of the No-fMRI group. Furthermore, patients with high-grade tumors showed significant survival benefits in the fMRI group, while patients with low-grade tumors did not (controlling for age and ECM). There was also a significant difference in the two groups with respect to morbidity, with patients receiving fMRI showing improved outcomes in the motor and language domains. Conclusions: This study analyzing a large retrospective series of brain tumor patients with and without the use of fMRI in the preoperative planning has resulted in improved mortality and morbidity outcomes with the use of fMRI. These results point to the importance of incorporating fMRI in presurgical planning in the clinical management of patients with brain tumors. Keywords: Brain mapping, Brain tumors, Functional neuroimaging |
| first_indexed | 2024-04-11T22:51:46Z |
| format | Article |
| id | doaj.art-6562bd762fdb4e52be967135b6012ce4 |
| institution | Directory Open Access Journal |
| issn | 2214-7519 |
| language | English |
| last_indexed | 2024-04-11T22:51:46Z |
| publishDate | 2018-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Interdisciplinary Neurosurgery |
| spelling | doaj.art-6562bd762fdb4e52be967135b6012ce42022-12-22T03:58:33ZengElsevierInterdisciplinary Neurosurgery2214-75192018-09-01134045Preoperative FMRI associated with decreased mortality and morbidity in brain tumor patientsS. Vysotski0C. Madura1B. Swan2R. Holdsworth3Y. Lin4A. Munoz Del Rio5J. Wood6B. Kundu7A. Penwarden8J. Voss9T. Gallagher10V.A. Nair11A. Field12C. Garcia-Ramos13M.E. Meyerand14M. Baskaya15V. Prabhakaran16J.S. Kuo17Department of Radiology, University of Wisconsin-Madison, School of Medicine and Public Health, 600 Highland Avenue, Madison, WI 53792-3252, USANeurological Surgery, University of Wisconsin-Madison, School of Medicine and Public Health, 600 Highland Avenue, Madison, WI 53792-3252, USADepartment of Radiology, Mount Auburn Hospital, 330 Mount Auburn Street, Cambridge, MA 02138, USADepartment of Radiology, University of Wisconsin-Madison, School of Medicine and Public Health, 600 Highland Avenue, Madison, WI 53792-3252, USADepartment of Statistics, University of Wisconsin Madison, 1300 University Avenue, Madison, WI 53705, USADepartment of Radiology, University of Wisconsin-Madison, School of Medicine and Public Health, 600 Highland Avenue, Madison, WI 53792-3252, USA; Department of Medical Physics, University of Wisconsin-Madison, Wisconsin Institutes for Medical Research (WIMR), 1111 Highland Avenue Rm 1005, Madison, WI 53705, USADepartment of General Surgery, UW Hospitals and Clinics, 600 Highland Avenue, Madison, WI 53792-3252, USAMedical Scientist Training Program, University of Wisconsin Madison, 6001 Research Park Blvd. Rm 1056, Madison, WI 51719, USADepartment of Anesthesiology, University of North Carolina -, Chapel Hill, 106 Bel Arbor Ln Carrboro, NC 27510, USADepartment of Radiology, University of Wisconsin-Madison, School of Medicine and Public Health, 600 Highland Avenue, Madison, WI 53792-3252, USADepartment of Radiology, Northwestern University Feinberg School of Medicine, NMH/Arkes Family Pavilion Suite 800, 676 N Saint Clair, Chicago, IL 60611, USADepartment of Radiology, University of Wisconsin-Madison, School of Medicine and Public Health, 600 Highland Avenue, Madison, WI 53792-3252, USADepartment of Radiology, University of Wisconsin Madison, School of Medicine and Public Health, 600 Highland Ave. M/C 3252, Madison, WI 53792-3252, USA; Department of Biomedical Engineering, University of Wisconsin-Madison, 1550 Engineering Dr, Madison, WI 53706, USADepartment of Medical Physics, University of Wisconsin-Madison, Wisconsin Institutes for Medical Research (WIMR), 1111 Highland Avenue Rm 1005, Madison, WI 53705, USADepartment of Biomedical Engineering, University of Wisconsin-Madison, 1550 Engineering Dr, Madison, WI 53706, USA; Department of Medical Physics, University of Wisconsin-Madison, 1111 Highland Ave., Suite 1129, Wisconsin Institutes for Medical Research (WIMR), Madison, WI 53705, USANeurological Surgery, University of Wisconsin-Madison, School of Medicine and Public Health, K3/803 Clinical Science Center, Mail Code 8660, 600 Highland Avenue, Madison, WI 53792-3252, USADepartment of Radiology, Director of Functional Neuroimaging in Radiology, University of Wisconsin Madison, School of Medicine and Public Health, 600 Highland Avenue, Madison, WI 53792-3252, USA; Corresponding author at: UWHealth UW Hospital and Clinics Department of Radiology, Wisconsin Institutes for Medical Research, Rm 1314, 1111 Highland Avenue, Madison, WI 53705, USA.UW Carbone Cancer Center, University of Wisconsin-Madison, 600 Highland Ave, Madison, WI 53792, USA; UW Center for Stem Cell and Regenerative Medicine, University of Wisconsin-Madison, School of Medicine and Public Health, K3/803 Clinical Science Center, Mail Code 8660, 600 Highland Avenue, Madison, WI 53792-3252, USABackground: Functional Magnetic Resonance Imaging (fMRI) is a presurgical planning technique used to localize functional cortex so as to maximize resection of diseased tissue and avoid viable tissue. In this retrospective study, we examined differences in morbidity and mortality of brain tumor patients who received preoperative fMRI in comparison to those who did not. Methods: Brain tumor patients (n = 206) were selected from a retrospective review of neurosurgical case logs from 2001 to 2009 at the University of Wisconsin-Madison. Results: Univariate analysis showed improved mortality in the fMRI group and the fMRI + Electrical Cortical Stimulation Mapping (ECM) group compared to the No-fMRI group. Multivariate analyses showed improved mortality of the fMRI group and the fMRI + ECM group compared to the No-fMRI group, with age and tumor grade being the most significant influencers. Overall, the fMRI group showed survival benefits at 3 years; twice that of the No-fMRI group. Furthermore, patients with high-grade tumors showed significant survival benefits in the fMRI group, while patients with low-grade tumors did not (controlling for age and ECM). There was also a significant difference in the two groups with respect to morbidity, with patients receiving fMRI showing improved outcomes in the motor and language domains. Conclusions: This study analyzing a large retrospective series of brain tumor patients with and without the use of fMRI in the preoperative planning has resulted in improved mortality and morbidity outcomes with the use of fMRI. These results point to the importance of incorporating fMRI in presurgical planning in the clinical management of patients with brain tumors. Keywords: Brain mapping, Brain tumors, Functional neuroimaginghttp://www.sciencedirect.com/science/article/pii/S2214751917302293 |
| spellingShingle | S. Vysotski C. Madura B. Swan R. Holdsworth Y. Lin A. Munoz Del Rio J. Wood B. Kundu A. Penwarden J. Voss T. Gallagher V.A. Nair A. Field C. Garcia-Ramos M.E. Meyerand M. Baskaya V. Prabhakaran J.S. Kuo Preoperative FMRI associated with decreased mortality and morbidity in brain tumor patients Interdisciplinary Neurosurgery |
| title | Preoperative FMRI associated with decreased mortality and morbidity in brain tumor patients |
| title_full | Preoperative FMRI associated with decreased mortality and morbidity in brain tumor patients |
| title_fullStr | Preoperative FMRI associated with decreased mortality and morbidity in brain tumor patients |
| title_full_unstemmed | Preoperative FMRI associated with decreased mortality and morbidity in brain tumor patients |
| title_short | Preoperative FMRI associated with decreased mortality and morbidity in brain tumor patients |
| title_sort | preoperative fmri associated with decreased mortality and morbidity in brain tumor patients |
| url | http://www.sciencedirect.com/science/article/pii/S2214751917302293 |
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