Role of gamma-delta T cells in host response against <it>Staphylococcus aureus</it>-induced pneumonia
<p>Abstract</p> <p>Background</p> <p><it>Staphylococcus aureus</it> is the major cause of hospital-acquired and community-acquired pneumonia. Host defense to <it>S.aureus</it> infection is largely mediated by the innate immune system. γδ T cells...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-07-01
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| Series: | BMC Immunology |
| Online Access: | http://www.biomedcentral.com/1471-2172/13/38 |
| _version_ | 1818039934419730432 |
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| author | Cheng Ping Liu Tao Zhou Wei-Ying Zhuang Yuan Peng Liu-sheng Zhang Jin-yu Yin Zhi-Nan Mao Xu-hu Guo Gang Shi Yun Zou Quan-ming |
| author_facet | Cheng Ping Liu Tao Zhou Wei-Ying Zhuang Yuan Peng Liu-sheng Zhang Jin-yu Yin Zhi-Nan Mao Xu-hu Guo Gang Shi Yun Zou Quan-ming |
| author_sort | Cheng Ping |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p><it>Staphylococcus aureus</it> is the major cause of hospital-acquired and community-acquired pneumonia. Host defense to <it>S.aureus</it> infection is largely mediated by the innate immune system. γδ T cells play an important role in innate immunity to many infectious diseases. However, less is known about the role of these cells during <it>S.aureus</it>-induced pneumonia. In this study, we examined the response and the role of γδ T cells to pulmonary <it>S.aureus</it> infection.</p> <p>Results</p> <p>Mice infected with <it>S. aureus</it> intranasally showed rapid γδ T cells accumulation in the lung. Deficiency of γδ T cells led to attenuated bacterial clearance and less tissue damage in lung compared with WT mice. Moreover, TCR-δ<sup>−/−</sup> mice exhibited impaired neutrophil recruitment and reduced cytokine production at the site of infection. The γδ T cells in response to pulmonary <it>S. aureus</it> infection mainly secreted IL-17 and γδ T cells deficiency reduced IL-17 production, which might regulate the production of neutrophil-inducing cytokine/chemokine in the <it>S. aureus</it>-infected lungs.</p> <p>Conclusions</p> <p>Accumulation of γδ T cells in the lungs to <it>S. aureus</it> infection is beneficial for bacteria clearance and also contributes to the tissue damage. These cells were the primary source of IL-17, which might influence the recruitment of neutrophils at the early stage of infection.</p> |
| first_indexed | 2024-12-10T08:06:31Z |
| format | Article |
| id | doaj.art-6567687c30274cd89c80a3bfb10aa52c |
| institution | Directory Open Access Journal |
| issn | 1471-2172 |
| language | English |
| last_indexed | 2024-12-10T08:06:31Z |
| publishDate | 2012-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Immunology |
| spelling | doaj.art-6567687c30274cd89c80a3bfb10aa52c2022-12-22T01:56:39ZengBMCBMC Immunology1471-21722012-07-011313810.1186/1471-2172-13-38Role of gamma-delta T cells in host response against <it>Staphylococcus aureus</it>-induced pneumoniaCheng PingLiu TaoZhou Wei-YingZhuang YuanPeng Liu-shengZhang Jin-yuYin Zhi-NanMao Xu-huGuo GangShi YunZou Quan-ming<p>Abstract</p> <p>Background</p> <p><it>Staphylococcus aureus</it> is the major cause of hospital-acquired and community-acquired pneumonia. Host defense to <it>S.aureus</it> infection is largely mediated by the innate immune system. γδ T cells play an important role in innate immunity to many infectious diseases. However, less is known about the role of these cells during <it>S.aureus</it>-induced pneumonia. In this study, we examined the response and the role of γδ T cells to pulmonary <it>S.aureus</it> infection.</p> <p>Results</p> <p>Mice infected with <it>S. aureus</it> intranasally showed rapid γδ T cells accumulation in the lung. Deficiency of γδ T cells led to attenuated bacterial clearance and less tissue damage in lung compared with WT mice. Moreover, TCR-δ<sup>−/−</sup> mice exhibited impaired neutrophil recruitment and reduced cytokine production at the site of infection. The γδ T cells in response to pulmonary <it>S. aureus</it> infection mainly secreted IL-17 and γδ T cells deficiency reduced IL-17 production, which might regulate the production of neutrophil-inducing cytokine/chemokine in the <it>S. aureus</it>-infected lungs.</p> <p>Conclusions</p> <p>Accumulation of γδ T cells in the lungs to <it>S. aureus</it> infection is beneficial for bacteria clearance and also contributes to the tissue damage. These cells were the primary source of IL-17, which might influence the recruitment of neutrophils at the early stage of infection.</p>http://www.biomedcentral.com/1471-2172/13/38 |
| spellingShingle | Cheng Ping Liu Tao Zhou Wei-Ying Zhuang Yuan Peng Liu-sheng Zhang Jin-yu Yin Zhi-Nan Mao Xu-hu Guo Gang Shi Yun Zou Quan-ming Role of gamma-delta T cells in host response against <it>Staphylococcus aureus</it>-induced pneumonia BMC Immunology |
| title | Role of gamma-delta T cells in host response against <it>Staphylococcus aureus</it>-induced pneumonia |
| title_full | Role of gamma-delta T cells in host response against <it>Staphylococcus aureus</it>-induced pneumonia |
| title_fullStr | Role of gamma-delta T cells in host response against <it>Staphylococcus aureus</it>-induced pneumonia |
| title_full_unstemmed | Role of gamma-delta T cells in host response against <it>Staphylococcus aureus</it>-induced pneumonia |
| title_short | Role of gamma-delta T cells in host response against <it>Staphylococcus aureus</it>-induced pneumonia |
| title_sort | role of gamma delta t cells in host response against it staphylococcus aureus it induced pneumonia |
| url | http://www.biomedcentral.com/1471-2172/13/38 |
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