Efficacy and Safety of Oral Factor XIa Inhibitors in Stroke Prevention: A Systematic Review and Meta-Analysis

Efficacy and Safety of Oral Factor XIa Inhibitors in Stroke Prevention: A Systematic Review and Meta-Analysis

Introduction: Despite preventive measures, stroke rates remain high in the primary and secondary prevention settings. Factor XIa inhibition may offer a novel, safe and effective antithrombotic option for stroke prevention. Methods: We conducted a systematic review and meta-analysis including all ava...

Full description

Bibliographic Details
Main Authors:	Lina Palaiodimou, Georgia Papagiannopoulou, Aristeidis H. Katsanos, Andreas Eleftheriou, Theodore Karapanayiotides, Panayiotis D. Mitsias, Robin Lemmens, Carlos A. Molina, Andrei Alexandrov, Valeria Caso, Ashkan Shoamanesh, Mukul Sharma, Georgios Tsivgoulis
Format:	Article
Language:	English
Published:	MDPI AG 2023-08-01
Series:	Journal of Clinical Medicine
Subjects:	ischemic stroke stroke prevention antithrombotic treatment anticoagulation factor Xia inhibitors meta-analysis
Online Access:	https://www.mdpi.com/2077-0383/12/17/5562

Similar Items

Improved efficacy/safety profile of factor XIa inhibitor BMS‐724296 versus factor Xa inhibitor apixaban and thrombin inhibitor dabigatran in cynomolgus monkeys
by: Pancras C. Wong, et al.
Published: (2021-05-01)

Lignosulfonic Acid Sodium Is a Noncompetitive Inhibitor of Human Factor XIa
by: Srabani Kar, et al.
Published: (2021-08-01)

Discovery of Benzyl Tetraphosphonate Derivative as Inhibitor of Human Factor Xia
by: Srabani Kar, et al.
Published: (2020-11-01)

A Factor XIa Inhibitor Engineered from Banded Krait Venom Toxin: Efficacy and Safety in Rodent Models of Arterial and Venous Thrombosis
by: Wei Seng Chng, et al.
Published: (2022-07-01)

Miaodigounization and Erlitounization: the formation and evolution of the Hua-Xia ethnic group and Hua-Xia tradition from the perspective of archaeology
by: Cao Bingwu
Published: (2022-05-01)

Rates and Determinants for the Use of Anticoagulation Treatment before Stroke in Patients with Known Atrial Fibrillation
by: Michela Giustozzi, et al.
Published: (2020-05-01)

Synthesis, Docking, and In Vitro Anticoagulant Activity Assay of Hybrid Derivatives of Pyrrolo[3,2,1-<i>ij</i>]Quinolin-2(1<i>H</i>)-one as New Inhibitors of Factor Xa and Factor XIa
by: Nadezhda Novichikhina, et al.
Published: (2020-04-01)

Factor XIa Inhibitors as a Novel Anticoagulation Target: Recent Clinical Research Advances
by: Yunqing Xia, et al.
Published: (2023-06-01)

Poor outcomes associated with antithrombotic undertreatment in patients with atrial fibrillation attending Gondar University Hospital: a retrospective cohort study
by: Eyob Alemayehu Gebreyohannes, et al.
Published: (2018-09-01)

Periprocedural Strategies for Stroke Prevention in Patients Undergoing Transcatheter Aortic Valve Implantation
by: Matthias Linder, et al.
Published: (2022-04-01)

Antithrombotics prescription and adherence among stroke survivors: A systematic review and meta‐analysis
by: Min Yang, et al.
Published: (2022-10-01)

Early Anticoagulation in Patients with Acute Ischemic Stroke Due to Atrial Fibrillation: A Systematic Review and Meta-Analysis
by: Lina Palaiodimou, et al.
Published: (2022-08-01)

Acquisition of "ZHU Xia's discussion on China's petroleum basin": Commemorating the 100th birthday of Mr. ZHU Xia
by: Zhijun JIN
Published: (2020-09-01)

AHDC1 missense mutations in Xia-Gibbs syndrome
by: Michael M. Khayat, et al.
Published: (2021-10-01)

Bleeding risk and mortality according to antithrombotic agents’ exposure in cancer-related stroke patients: nationwide population-based cohort study in South Korea
by: Bo Kyu Choi, et al.
Published: (2023-05-01)

Mortality Risk in Acute Ischemic Stroke Patients With Large Vessel Occlusion Treated With Mechanical Thrombectomy
by: Aristeidis H. Katsanos, et al.
Published: (2019-11-01)

Role of Different Antithrombotic Regimens after Percutaneous Left Atrial Appendage Occlusion: A Large Single Center Experience
by: Patrizio Mazzone, et al.
Published: (2021-05-01)

Use of Oral Anticoagulant for Secondary Prevention of Stroke in Very Elderly Patients With Atrial Fibrillation: An Observational Study
by: Ya-Ju Lin, et al.
Published: (2011-03-01)

Performance of the “CCS Algorithm” in real world patients
by: Stephen A. LaHaye, et al.
Published: (2015-06-01)

Xia-Yu-Xue Decoction Inhibits Intestinal Epithelial Cell Apoptosis in CCl4-Induced Liver Fibrosis
by: Wenting Ma, et al.
Published: (2017-11-01)

Focusing on Autism Spectrum Disorder in Xia–Gibbs Syndrome: Description of a Female with High Functioning Autism and Literature Review
by: Stefania Della Vecchia, et al.
Published: (2021-05-01)

From Xia People to Han People and to Chinese Nation — A Study of the Trajectory of the Cohesion and Integration of Chinese Ethnic Groups
by: Li Dalong, et al.
Published: (2019-03-01)

Assessment of Antithrombotic Therapy in Patients with Atrial Fibrillation for 2015-2017 According to the Registry of the Clinic of the Scientific Research Institute of Medical Problems of the North of Krasnoyarsk City
by: A. A. Tuchkov, et al.
Published: (2019-03-01)

Combining Intravenous Thrombolysis and Antithrombotic Agents in Stroke: An Update
by: Laurent Derex, et al.
Published: (2018-01-01)

Use of the CHADS2 risk score to guide antithrombotic treatment in patients with atrial fibrillation - room for improvement
by: Swiss Medical Weekly
Published: (2010-02-01)

Editorial: Antithrombotic Prophylaxis in Patients With Atrial Fibrillation for Stroke Prevention: Evidence From Randomized Clinical Trials, Observational Studies, Methodological Modeling, and More
by: Junguo Zhang, et al.
Published: (2021-02-01)

A Systematic Review of the Mysterious Caterpillar Fungus Ophiocordyceps sinensis in DongChongXiaCao (冬蟲夏草 Dōng Chóng Xià Cǎo) and Related Bioactive Ingredients
by: Hui-Chen Lo, et al.
Published: (2013-01-01)

Detecting factor XIa in immune globulin products: Commutability of international reference materials for traditional and global hemostasis assays
by: Yideng Liang, et al.
Published: (2021-01-01)

An Updated Meta-Analysis of RCTs of Colchicine for Stroke Prevention in Patients with Coronary Artery Disease
by: Aristeidis H. Katsanos, et al.
Published: (2021-07-01)

WARFARIN IN PATIENTS WITH CARDIOEMBOLIC STROKE
by: E. N. Dankovtseva, et al.
Published: (2015-12-01)

Ischemic stroke and antithrombotic therapy: key aspects
by: M. Yu. Maksimova, et al.
Published: (2019-12-01)

Efficacy and Safety of Edoxaban in Elderly Patients With Atrial Fibrillation in the ENGAGE AF–TIMI 48 Trial
by: Eri Toda Kato, et al.
Published: (2016-05-01)

The case for an elderly-targeted stroke management
by: Osvaldo eFustinoni
Published: (2011-12-01)

Blood Pressure Variability in Acute Stroke: A Narrative Review
by: Christina Zompola, et al.
Published: (2024-03-01)

Endovascular Treatment for Acute Basilar Artery Occlusion: A Fragility Index Meta-Analysis
by: Lina Palaiodimou, et al.
Published: (2023-03-01)

Update of Anticoagulation Use in Cardioembolic Stroke With a Special Reference to Endovascular Treatment
by: Apostolos Safouris, et al.
Published: (2024-01-01)

Ecological Security and Ecosystem Quality: A Case Study of Xia-Zhang-Quan Metropolitan Area in China
by: Fachao Liang, et al.
Published: (2022-05-01)

Editorial: Understanding PFO-associated stroke
by: Theodoros Karapanayiotides, et al.
Published: (2023-08-01)

Periodic Limb Movements during Sleep in Acute Stroke: Prevalence, Severity and Impact on Post-Stroke Recovery
by: Panagiotis Plomaritis, et al.
Published: (2023-09-01)

Prediction of Molecular Mechanisms for LianXia NingXin Formula: A Network Pharmacology Study
by: Yang Yang, et al.
Published: (2018-05-01)