Unlucky punches: the vulnerability-stress model for the development of impulse control disorders in Parkinson’s disease
Abstract Impulse-control disorders are commonly observed during dopamine-replacement therapy in Parkinson’s disease, but the majority of patients seems “immune” to this side effect. Epidemiological evidence suggests that a major risk factor may be a specific difference in the layout of the dopaminer...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-12-01
|
| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-021-00253-z |
| _version_ | 1797641206880010240 |
|---|---|
| author | Hendrik Theis Catharina Probst Pierre-Olivier Fernagut Thilo van Eimeren |
| author_facet | Hendrik Theis Catharina Probst Pierre-Olivier Fernagut Thilo van Eimeren |
| author_sort | Hendrik Theis |
| collection | DOAJ |
| description | Abstract Impulse-control disorders are commonly observed during dopamine-replacement therapy in Parkinson’s disease, but the majority of patients seems “immune” to this side effect. Epidemiological evidence suggests that a major risk factor may be a specific difference in the layout of the dopaminergic-reinforcement system, of which the ventral striatum is a central player. A series of imaging studies of the dopaminergic system point toward a presynaptic reduction of dopamine-reuptake transporter density and dopamine synthesis capacity. Here, we review current evidence for a vulnerability-stress model in which a relative reduction of dopaminergic projections to the ventral striatum and concomitant sensitization of postsynaptic neurons represent a predisposing (hypodopaminergic) vulnerability. Stress (hyperdopaminergic) is delivered when dopamine replacement therapy leads to a relative overdosing of the already-sensitized ventral striatum. These alterations are consistent with consecutive changes in reinforcement mechanisms, which stimulate learning from reward and impede learning from punishment, thereby fostering the development of impulse-control disorders. This vulnerability-stress model might also provide important insights into the development of addictions in the non-Parkinsonian population. |
| first_indexed | 2024-03-11T13:42:15Z |
| format | Article |
| id | doaj.art-6568bcc4d3d74378b5a605904e087140 |
| institution | Directory Open Access Journal |
| issn | 2373-8057 |
| language | English |
| last_indexed | 2024-03-11T13:42:15Z |
| publishDate | 2021-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj.art-6568bcc4d3d74378b5a605904e0871402023-11-02T11:37:35ZengNature Portfolionpj Parkinson's Disease2373-80572021-12-01711810.1038/s41531-021-00253-zUnlucky punches: the vulnerability-stress model for the development of impulse control disorders in Parkinson’s diseaseHendrik Theis0Catharina Probst1Pierre-Olivier Fernagut2Thilo van Eimeren3University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Nuclear Medicine and Department of NeurologyUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Nuclear Medicine and Department of NeurologyUniversité de Poitiers, INSERM, Laboratoire de Neurosciences Expérimentales et CliniquesUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Nuclear Medicine and Department of NeurologyAbstract Impulse-control disorders are commonly observed during dopamine-replacement therapy in Parkinson’s disease, but the majority of patients seems “immune” to this side effect. Epidemiological evidence suggests that a major risk factor may be a specific difference in the layout of the dopaminergic-reinforcement system, of which the ventral striatum is a central player. A series of imaging studies of the dopaminergic system point toward a presynaptic reduction of dopamine-reuptake transporter density and dopamine synthesis capacity. Here, we review current evidence for a vulnerability-stress model in which a relative reduction of dopaminergic projections to the ventral striatum and concomitant sensitization of postsynaptic neurons represent a predisposing (hypodopaminergic) vulnerability. Stress (hyperdopaminergic) is delivered when dopamine replacement therapy leads to a relative overdosing of the already-sensitized ventral striatum. These alterations are consistent with consecutive changes in reinforcement mechanisms, which stimulate learning from reward and impede learning from punishment, thereby fostering the development of impulse-control disorders. This vulnerability-stress model might also provide important insights into the development of addictions in the non-Parkinsonian population.https://doi.org/10.1038/s41531-021-00253-z |
| spellingShingle | Hendrik Theis Catharina Probst Pierre-Olivier Fernagut Thilo van Eimeren Unlucky punches: the vulnerability-stress model for the development of impulse control disorders in Parkinson’s disease npj Parkinson's Disease |
| title | Unlucky punches: the vulnerability-stress model for the development of impulse control disorders in Parkinson’s disease |
| title_full | Unlucky punches: the vulnerability-stress model for the development of impulse control disorders in Parkinson’s disease |
| title_fullStr | Unlucky punches: the vulnerability-stress model for the development of impulse control disorders in Parkinson’s disease |
| title_full_unstemmed | Unlucky punches: the vulnerability-stress model for the development of impulse control disorders in Parkinson’s disease |
| title_short | Unlucky punches: the vulnerability-stress model for the development of impulse control disorders in Parkinson’s disease |
| title_sort | unlucky punches the vulnerability stress model for the development of impulse control disorders in parkinson s disease |
| url | https://doi.org/10.1038/s41531-021-00253-z |
| work_keys_str_mv | AT hendriktheis unluckypunchesthevulnerabilitystressmodelforthedevelopmentofimpulsecontroldisordersinparkinsonsdisease AT catharinaprobst unluckypunchesthevulnerabilitystressmodelforthedevelopmentofimpulsecontroldisordersinparkinsonsdisease AT pierreolivierfernagut unluckypunchesthevulnerabilitystressmodelforthedevelopmentofimpulsecontroldisordersinparkinsonsdisease AT thilovaneimeren unluckypunchesthevulnerabilitystressmodelforthedevelopmentofimpulsecontroldisordersinparkinsonsdisease |