Electrospun Nanofibrous Membranes for Tissue Engineering and Cell Growth
In biotechnology, the field of cell cultivation is highly relevant. Cultivated cells can be used, for example, for the development of biopharmaceuticals and in tissue engineering. Commonly, mammalian cells are grown in bioreactors, T-flasks, well plates, etc., without a specific substrate. Nanofibro...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-07-01
|
| Series: | Applied Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3417/11/15/6929 |
| _version_ | 1827686648253513728 |
|---|---|
| author | Ewin Tanzli Andrea Ehrmann |
| author_facet | Ewin Tanzli Andrea Ehrmann |
| author_sort | Ewin Tanzli |
| collection | DOAJ |
| description | In biotechnology, the field of cell cultivation is highly relevant. Cultivated cells can be used, for example, for the development of biopharmaceuticals and in tissue engineering. Commonly, mammalian cells are grown in bioreactors, T-flasks, well plates, etc., without a specific substrate. Nanofibrous mats, however, have been reported to promote cell growth, adhesion, and proliferation. Here, we give an overview of the different attempts at cultivating mammalian cells on electrospun nanofiber mats for biotechnological and biomedical purposes. Starting with a brief overview of the different electrospinning methods, resulting in random or defined fiber orientations in the nanofiber mats, we describe the typical materials used in cell growth applications in biotechnology and tissue engineering. The influence of using different surface morphologies and polymers or polymer blends on the possible application of such nanofiber mats for tissue engineering and other biotechnological applications is discussed. Polymer blends, in particular, can often be used to reach the required combination of mechanical and biological properties, making such nanofiber mats highly suitable for tissue engineering and other biotechnological or biomedical cell growth applications. |
| first_indexed | 2024-03-10T09:18:48Z |
| format | Article |
| id | doaj.art-6568f737930d49139feca905398961b7 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T09:18:48Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-6568f737930d49139feca905398961b72023-11-22T05:21:44ZengMDPI AGApplied Sciences2076-34172021-07-011115692910.3390/app11156929Electrospun Nanofibrous Membranes for Tissue Engineering and Cell GrowthEwin Tanzli0Andrea Ehrmann1Faculty of Engineering and Mathematics, Bielefeld University of Applied Sciences, Interaktion 1, 33619 Bielefeld, GermanyFaculty of Engineering and Mathematics, Bielefeld University of Applied Sciences, Interaktion 1, 33619 Bielefeld, GermanyIn biotechnology, the field of cell cultivation is highly relevant. Cultivated cells can be used, for example, for the development of biopharmaceuticals and in tissue engineering. Commonly, mammalian cells are grown in bioreactors, T-flasks, well plates, etc., without a specific substrate. Nanofibrous mats, however, have been reported to promote cell growth, adhesion, and proliferation. Here, we give an overview of the different attempts at cultivating mammalian cells on electrospun nanofiber mats for biotechnological and biomedical purposes. Starting with a brief overview of the different electrospinning methods, resulting in random or defined fiber orientations in the nanofiber mats, we describe the typical materials used in cell growth applications in biotechnology and tissue engineering. The influence of using different surface morphologies and polymers or polymer blends on the possible application of such nanofiber mats for tissue engineering and other biotechnological applications is discussed. Polymer blends, in particular, can often be used to reach the required combination of mechanical and biological properties, making such nanofiber mats highly suitable for tissue engineering and other biotechnological or biomedical cell growth applications.https://www.mdpi.com/2076-3417/11/15/6929cell growthelectrospinningnanofibrous membraneadherent cellsbiomedicine |
| spellingShingle | Ewin Tanzli Andrea Ehrmann Electrospun Nanofibrous Membranes for Tissue Engineering and Cell Growth Applied Sciences cell growth electrospinning nanofibrous membrane adherent cells biomedicine |
| title | Electrospun Nanofibrous Membranes for Tissue Engineering and Cell Growth |
| title_full | Electrospun Nanofibrous Membranes for Tissue Engineering and Cell Growth |
| title_fullStr | Electrospun Nanofibrous Membranes for Tissue Engineering and Cell Growth |
| title_full_unstemmed | Electrospun Nanofibrous Membranes for Tissue Engineering and Cell Growth |
| title_short | Electrospun Nanofibrous Membranes for Tissue Engineering and Cell Growth |
| title_sort | electrospun nanofibrous membranes for tissue engineering and cell growth |
| topic | cell growth electrospinning nanofibrous membrane adherent cells biomedicine |
| url | https://www.mdpi.com/2076-3417/11/15/6929 |
| work_keys_str_mv | AT ewintanzli electrospunnanofibrousmembranesfortissueengineeringandcellgrowth AT andreaehrmann electrospunnanofibrousmembranesfortissueengineeringandcellgrowth |