Immunomodulatory activities of gemifloxacin in mice
Objective(s):Gemifloxacin is a broad spectrum antibiotic and has shown excellent coverage against a wide variety of microorganisms. In this study, an attempt was made to evaluate the immunomodulatory potential of gemifloxacin in male swiss albino mice in vivo. Materials and Methods: Three doses of g...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2016-09-01
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| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | http://ijbms.mums.ac.ir/article_7599_520d003f9030f5748d7645f6d011ac7e.pdf |
| _version_ | 1830273137286053888 |
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| author | Muhammad Umair Aqeel Javeed Aamir Ghafoor Muhammad Ashraf |
| author_facet | Muhammad Umair Aqeel Javeed Aamir Ghafoor Muhammad Ashraf |
| author_sort | Muhammad Umair |
| collection | DOAJ |
| description | Objective(s):Gemifloxacin is a broad spectrum antibiotic and has shown excellent coverage against a wide variety of microorganisms. In this study, an attempt was made to evaluate the immunomodulatory potential of gemifloxacin in male swiss albino mice in vivo.
Materials and Methods: Three doses of gemifloxacin 25 mg/kg, 50 mg/kg and 75 mg/kg were used intraperitoneally (IP) for the evaluation of immune responses in mice. Delayed type hypersensitivity (DTH), heamagglutination assay, jerne hemolytic plaque formation assay and cyclophosphamide induced neutropenia assay were performed to evaluate the effect of gemifloxacin on immune responses.
Results: DTH assay has shown the significant immune suppressant potential of gemifloxacin at 25 mg/kg dose and 75mg/kg dose. Total leukocyte count (TLC) has shown decrease in leukocyte count (P |
| first_indexed | 2024-12-18T23:39:31Z |
| format | Article |
| id | doaj.art-65699237da9c48098558d25a8636f425 |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-12-18T23:39:31Z |
| publishDate | 2016-09-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-65699237da9c48098558d25a8636f4252022-12-21T20:47:25ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742016-09-0119998599210.22038/ijbms.2016.75997599Immunomodulatory activities of gemifloxacin in miceMuhammad Umair0Aqeel Javeed1Aamir Ghafoor2Muhammad Ashraf3Department of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore, PakistanDepartment of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore, PakistanUniversity Diagnostics Laboratory, University of Veterinary and Animal Sciences, Lahore, PakistanDepartment of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore, PakistanObjective(s):Gemifloxacin is a broad spectrum antibiotic and has shown excellent coverage against a wide variety of microorganisms. In this study, an attempt was made to evaluate the immunomodulatory potential of gemifloxacin in male swiss albino mice in vivo. Materials and Methods: Three doses of gemifloxacin 25 mg/kg, 50 mg/kg and 75 mg/kg were used intraperitoneally (IP) for the evaluation of immune responses in mice. Delayed type hypersensitivity (DTH), heamagglutination assay, jerne hemolytic plaque formation assay and cyclophosphamide induced neutropenia assay were performed to evaluate the effect of gemifloxacin on immune responses. Results: DTH assay has shown the significant immune suppressant potential of gemifloxacin at 25 mg/kg dose and 75mg/kg dose. Total leukocyte count (TLC) has shown decrease in leukocyte count (Phttp://ijbms.mums.ac.ir/article_7599_520d003f9030f5748d7645f6d011ac7e.pdfGemifloxacinImmunomodulatoryImmune responseCell mediatedHumoral |
| spellingShingle | Muhammad Umair Aqeel Javeed Aamir Ghafoor Muhammad Ashraf Immunomodulatory activities of gemifloxacin in mice Iranian Journal of Basic Medical Sciences Gemifloxacin Immunomodulatory Immune response Cell mediated Humoral |
| title | Immunomodulatory activities of gemifloxacin in mice |
| title_full | Immunomodulatory activities of gemifloxacin in mice |
| title_fullStr | Immunomodulatory activities of gemifloxacin in mice |
| title_full_unstemmed | Immunomodulatory activities of gemifloxacin in mice |
| title_short | Immunomodulatory activities of gemifloxacin in mice |
| title_sort | immunomodulatory activities of gemifloxacin in mice |
| topic | Gemifloxacin Immunomodulatory Immune response Cell mediated Humoral |
| url | http://ijbms.mums.ac.ir/article_7599_520d003f9030f5748d7645f6d011ac7e.pdf |
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