Nasopharyngeal bacterial carriage and antimicrobial resistance in underfive children with community acquired pneumonia
Lung puncture is the best way to determine the etiology of pneumonia since it yields the highest rate of positive cultures. However, this procedure is difficult, especially for a study in the community. According to WHO, isolates to be tested for antimicrobial resistance in the community should be o...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Indonesian Pediatric Society Publishing House
2001-12-01
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| Series: | Paediatrica Indonesiana |
| Subjects: | |
| Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1045 |
| _version_ | 1818196000857128960 |
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| author | Cissy B. Kartasasmita Heda Melinda Duddy Sunaryati Sudigdoadi Dwi Agustian Ina Setiowati Tri Hanggono Ahmad Ramdan Panigoro |
| author_facet | Cissy B. Kartasasmita Heda Melinda Duddy Sunaryati Sudigdoadi Dwi Agustian Ina Setiowati Tri Hanggono Ahmad Ramdan Panigoro |
| author_sort | Cissy B. Kartasasmita |
| collection | DOAJ |
| description | Lung puncture is the best way to determine the etiology of pneumonia since it yields the highest rate of positive cultures. However, this procedure is difficult, especially for a study in the community. According to WHO, isolates to be tested for antimicrobial resistance in the community should be obtained from nasopharyngeal (NP) swabs. Previous studies support the use of NP isolates to determine antimicrobial resistance patterns of isolates from children with pneumonia. The aim of our study was to know the bacterial patterns of the nasopharynx in underfive children with community acquired pneumonia and their antimicrobial resistance. The study was carried out in 4 Primary Health Clinics in Majalaya sub-district, Bandung, Indonesia. All underfives with cough or difficult breathing and classified as having non-severe pneumonia (WHO guidelines), were included in the study. Nasopharyngeal swabs (CDC/WHO Manual) were obtained by the doctor, the swabs were placed in Amies transport medium and stored in a sterile jar before taken to the laboratory in the same day. All children were treated with co-trimoxazole. During the nine month study, 698 children with clinical signs of non-severe pneumonia were enrolled. About 25% of the nasopharyngeal specimens yielded bacterial isolates; the two most frequently found were S. pneumoniae and S. epidermidis. The antimicrobial resistance test to co-trimoxazole showed 48.2% S. pneumoniae strain had full resistance and 32.7% showed intermediate resistance to co-trimoxazole. This result is almost similar to other studies from Asian countries. It seems that H. influenzae is not a problem in the study area; however, further studies are needed. |
| first_indexed | 2024-12-12T01:27:08Z |
| format | Article |
| id | doaj.art-656a2d0e1fdc4e1cacbab7d7700de7c1 |
| institution | Directory Open Access Journal |
| issn | 0030-9311 2338-476X |
| language | English |
| last_indexed | 2024-12-12T01:27:08Z |
| publishDate | 2001-12-01 |
| publisher | Indonesian Pediatric Society Publishing House |
| record_format | Article |
| series | Paediatrica Indonesiana |
| spelling | doaj.art-656a2d0e1fdc4e1cacbab7d7700de7c12022-12-22T00:43:04ZengIndonesian Pediatric Society Publishing HousePaediatrica Indonesiana0030-93112338-476X2001-12-01416292510.14238/pi41.6.2001.292-5867Nasopharyngeal bacterial carriage and antimicrobial resistance in underfive children with community acquired pneumoniaCissy B. Kartasasmita0Heda Melinda Duddy1Sunaryati Sudigdoadi2Dwi Agustian3Ina Setiowati4Tri Hanggono Ahmad5Ramdan Panigoro6Departments of Child Health, Universitas Padjadjaran Medical School/Dr. Hasan Sadikin General Hospital, Bandung, West JavaDepartments of Child Health, Universitas Padjadjaran Medical School/Dr. Hasan Sadikin General Hospital, Bandung, West JavaMicrobiology, Universitas Padjadjaran Medical School/Dr. Hasan Sadikin General Hospital, Bandung, West JavaThe Research Unit, Universitas Padjadjaran Medical School/Dr. Hasan Sadikin General Hospital, Bandung, West JavaThe Research Unit, Universitas Padjadjaran Medical School/Dr. Hasan Sadikin General Hospital, Bandung, West JavaThe Research Unit, Universitas Padjadjaran Medical School/Dr. Hasan Sadikin General Hospital, Bandung, West JavaThe Research Unit, Universitas Padjadjaran Medical School/Dr. Hasan Sadikin General Hospital, Bandung, West JavaLung puncture is the best way to determine the etiology of pneumonia since it yields the highest rate of positive cultures. However, this procedure is difficult, especially for a study in the community. According to WHO, isolates to be tested for antimicrobial resistance in the community should be obtained from nasopharyngeal (NP) swabs. Previous studies support the use of NP isolates to determine antimicrobial resistance patterns of isolates from children with pneumonia. The aim of our study was to know the bacterial patterns of the nasopharynx in underfive children with community acquired pneumonia and their antimicrobial resistance. The study was carried out in 4 Primary Health Clinics in Majalaya sub-district, Bandung, Indonesia. All underfives with cough or difficult breathing and classified as having non-severe pneumonia (WHO guidelines), were included in the study. Nasopharyngeal swabs (CDC/WHO Manual) were obtained by the doctor, the swabs were placed in Amies transport medium and stored in a sterile jar before taken to the laboratory in the same day. All children were treated with co-trimoxazole. During the nine month study, 698 children with clinical signs of non-severe pneumonia were enrolled. About 25% of the nasopharyngeal specimens yielded bacterial isolates; the two most frequently found were S. pneumoniae and S. epidermidis. The antimicrobial resistance test to co-trimoxazole showed 48.2% S. pneumoniae strain had full resistance and 32.7% showed intermediate resistance to co-trimoxazole. This result is almost similar to other studies from Asian countries. It seems that H. influenzae is not a problem in the study area; however, further studies are needed.https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1045community acquired pneumonianasopharyngeal carriageS. pneumoniaeantimicrobial resistance |
| spellingShingle | Cissy B. Kartasasmita Heda Melinda Duddy Sunaryati Sudigdoadi Dwi Agustian Ina Setiowati Tri Hanggono Ahmad Ramdan Panigoro Nasopharyngeal bacterial carriage and antimicrobial resistance in underfive children with community acquired pneumonia Paediatrica Indonesiana community acquired pneumonia nasopharyngeal carriage S. pneumoniae antimicrobial resistance |
| title | Nasopharyngeal bacterial carriage and antimicrobial resistance in underfive children with community acquired pneumonia |
| title_full | Nasopharyngeal bacterial carriage and antimicrobial resistance in underfive children with community acquired pneumonia |
| title_fullStr | Nasopharyngeal bacterial carriage and antimicrobial resistance in underfive children with community acquired pneumonia |
| title_full_unstemmed | Nasopharyngeal bacterial carriage and antimicrobial resistance in underfive children with community acquired pneumonia |
| title_short | Nasopharyngeal bacterial carriage and antimicrobial resistance in underfive children with community acquired pneumonia |
| title_sort | nasopharyngeal bacterial carriage and antimicrobial resistance in underfive children with community acquired pneumonia |
| topic | community acquired pneumonia nasopharyngeal carriage S. pneumoniae antimicrobial resistance |
| url | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/1045 |
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