Anticancer activity and mechanisms of action of Taisui fermentation broth in human colorectal cancer HCT116 cells in vitro and in vivo
Taisui, an unclassified biological object, is considered as a functional food with rich medicinal value in ancient Chinese books. However, there are few studies on Taisui, particularly on its anticancer activity and underlying mechanisms. Herein, we evaluated the anticancer potential of Taisui ferme...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623001925 |
| _version_ | 1797801772241125376 |
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| author | Xiaoming Zhao Tianzhuo Sui Zhendong Fu Leichao Zhang Yiyao Gao Liping Wang Hui Zhang |
| author_facet | Xiaoming Zhao Tianzhuo Sui Zhendong Fu Leichao Zhang Yiyao Gao Liping Wang Hui Zhang |
| author_sort | Xiaoming Zhao |
| collection | DOAJ |
| description | Taisui, an unclassified biological object, is considered as a functional food with rich medicinal value in ancient Chinese books. However, there are few studies on Taisui, particularly on its anticancer activity and underlying mechanisms. Herein, we evaluated the anticancer potential of Taisui fermentation broth using HCT116 cells and nude mice xenografts in vitro and in vivo. Taisui fermentation broth inhibited HCT116 cells proliferation by inducing S-phase arrest, apoptosis, and autophagy, by regulating related proteins. Taisui fermentation broth-induced HCT116 cells death was reversed by inhibiting apoptosis and autophagy. Autophagy inhibition suppressed Taisui fermentation broth-induced apoptosis, whereas apoptosis inhibition attenuated Taisui fermentation broth-induced autophagy. Taisui fermentation broth induced apoptosis and autophagy by regulating reactive oxygen species-mediated c-Jun NH2-terminal kinase/p38 signaling in HCT116 cells. Additionally, Taisui fermentation broth inhibited tumor growth in a mouse xenograft model. Taisui fermentation broth may be a promising anticancer agent for the treatment of colorectal cancer. |
| first_indexed | 2024-03-13T04:55:33Z |
| format | Article |
| id | doaj.art-656ace2b3e9942939101ea41c6409c56 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-13T04:55:33Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-656ace2b3e9942939101ea41c6409c562023-06-18T05:01:21ZengElsevierJournal of Functional Foods1756-46462023-07-01106105592Anticancer activity and mechanisms of action of Taisui fermentation broth in human colorectal cancer HCT116 cells in vitro and in vivoXiaoming Zhao0Tianzhuo Sui1Zhendong Fu2Leichao Zhang3Yiyao Gao4Liping Wang5Hui Zhang6Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun, ChinaScientific Research Center, China-Japan Union Hospital of Jilin University, Changchun, China; School of Life Sciences, Jilin University, Changchun, ChinaSchool of Life Sciences, Jilin University, Changchun, ChinaDepartment of Pathology, China-Japan Union Hospital of Jilin University, Changchun, ChinaScientific Research Center, China-Japan Union Hospital of Jilin University, Changchun, ChinaSchool of Life Sciences, Jilin University, Changchun, ChinaThe Second Hospital of Jilin University, Changchun, China; Corresponding author at: The Second Hospital of Jilin University, Changchun 130041, China.Taisui, an unclassified biological object, is considered as a functional food with rich medicinal value in ancient Chinese books. However, there are few studies on Taisui, particularly on its anticancer activity and underlying mechanisms. Herein, we evaluated the anticancer potential of Taisui fermentation broth using HCT116 cells and nude mice xenografts in vitro and in vivo. Taisui fermentation broth inhibited HCT116 cells proliferation by inducing S-phase arrest, apoptosis, and autophagy, by regulating related proteins. Taisui fermentation broth-induced HCT116 cells death was reversed by inhibiting apoptosis and autophagy. Autophagy inhibition suppressed Taisui fermentation broth-induced apoptosis, whereas apoptosis inhibition attenuated Taisui fermentation broth-induced autophagy. Taisui fermentation broth induced apoptosis and autophagy by regulating reactive oxygen species-mediated c-Jun NH2-terminal kinase/p38 signaling in HCT116 cells. Additionally, Taisui fermentation broth inhibited tumor growth in a mouse xenograft model. Taisui fermentation broth may be a promising anticancer agent for the treatment of colorectal cancer.http://www.sciencedirect.com/science/article/pii/S1756464623001925AnticancerColorectal CancerTaisuiApoptosisAutophagy |
| spellingShingle | Xiaoming Zhao Tianzhuo Sui Zhendong Fu Leichao Zhang Yiyao Gao Liping Wang Hui Zhang Anticancer activity and mechanisms of action of Taisui fermentation broth in human colorectal cancer HCT116 cells in vitro and in vivo Journal of Functional Foods Anticancer Colorectal Cancer Taisui Apoptosis Autophagy |
| title | Anticancer activity and mechanisms of action of Taisui fermentation broth in human colorectal cancer HCT116 cells in vitro and in vivo |
| title_full | Anticancer activity and mechanisms of action of Taisui fermentation broth in human colorectal cancer HCT116 cells in vitro and in vivo |
| title_fullStr | Anticancer activity and mechanisms of action of Taisui fermentation broth in human colorectal cancer HCT116 cells in vitro and in vivo |
| title_full_unstemmed | Anticancer activity and mechanisms of action of Taisui fermentation broth in human colorectal cancer HCT116 cells in vitro and in vivo |
| title_short | Anticancer activity and mechanisms of action of Taisui fermentation broth in human colorectal cancer HCT116 cells in vitro and in vivo |
| title_sort | anticancer activity and mechanisms of action of taisui fermentation broth in human colorectal cancer hct116 cells in vitro and in vivo |
| topic | Anticancer Colorectal Cancer Taisui Apoptosis Autophagy |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623001925 |
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