3-O-Methyltolcapone and Its Lipophilic Analogues Are Potent Inhibitors of Transthyretin Amyloidogenesis with High Permeability and Low Toxicity

3-O-Methyltolcapone and Its Lipophilic Analogues Are Potent Inhibitors of Transthyretin Amyloidogenesis with High Permeability and Low Toxicity

Transthyretin (TTR) is an amyloidogenic homotetramer involved in the transport of thyroxine in blood and cerebrospinal fluid. To date, more than 130 TTR point mutations are known to destabilise the TTR tetramer, leading to its extracellular pathological aggregation accumulating in several organs, su...

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Bibliographic Details
Main Authors: Thanalai Poonsiri, Davide Dell’Accantera, Valentina Loconte, Alessandro Casnati, Laura Cervoni, Alessandro Arcovito, Stefano Benini, Alberto Ferrari, Marco Cipolloni, Elisa Cacioni, Francesca De Franco, Nicola Giacchè, Serena Rinaldo, Claudia Folli, Francesco Sansone, Rodolfo Berni, Michele Cianci
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:International Journal of Molecular Sciences
Subjects:
transthyretin
amyloidogenesis inhibitors
neuronal and hepatic safety
tolcapone analogues
molecular docking and structure
Online Access:https://www.mdpi.com/1422-0067/25/1/479

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https://www.mdpi.com/1422-0067/25/1/479

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