Pro12Ala gene polymorphism in the peroxisome proliferator-activated receptor gamma as a risk factor for the onset of type 2 diabetes mellitus in the Serbian population
The peroxisome proliferator-activated receptor gamma (PPARγ) is a gene candidate for the onset of type 2 diabetes mellitus (T2DM). We investigated the association of the PPARγ Pro12Ala gene with the onset of T2DM for the first time in the Serbian population. The study population consisted of 197 con...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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University of Belgrade, University of Novi Sad
2010-01-01
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| Series: | Archives of Biological Sciences |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-4664/2010/0354-46641002263S.pdf |
| _version_ | 1829497190971604992 |
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| author | Šoškić Sanja Stanković Aleksandra Đurić Tamara Živković Maja Ristić P. Anđelković Z. Šumarac-Dumanović Mirjana Alavantić D. |
| author_facet | Šoškić Sanja Stanković Aleksandra Đurić Tamara Živković Maja Ristić P. Anđelković Z. Šumarac-Dumanović Mirjana Alavantić D. |
| author_sort | Šoškić Sanja |
| collection | DOAJ |
| description | The peroxisome proliferator-activated receptor gamma (PPARγ) is a gene candidate for the onset of type 2 diabetes mellitus (T2DM). We investigated the association of the PPARγ Pro12Ala gene with the onset of T2DM for the first time in the Serbian population. The study population consisted of 197 controls and 163 T2DM patients. The 12Ala allele tended to be more frequent in the group of T2DM patients (0.11) compared to the control subjects (0.09). The results from this study indicate that the PPARγ2 12Ala allele presents a non-significant risk factor for T2DM development in the Serbian population. |
| first_indexed | 2024-12-16T07:45:07Z |
| format | Article |
| id | doaj.art-656d69add418422581fa8c49d51234d0 |
| institution | Directory Open Access Journal |
| issn | 0354-4664 |
| language | English |
| last_indexed | 2024-12-16T07:45:07Z |
| publishDate | 2010-01-01 |
| publisher | University of Belgrade, University of Novi Sad |
| record_format | Article |
| series | Archives of Biological Sciences |
| spelling | doaj.art-656d69add418422581fa8c49d51234d02022-12-21T22:38:58ZengUniversity of Belgrade, University of Novi SadArchives of Biological Sciences0354-46642010-01-0162226327010.2298/ABS1002263SPro12Ala gene polymorphism in the peroxisome proliferator-activated receptor gamma as a risk factor for the onset of type 2 diabetes mellitus in the Serbian populationŠoškić SanjaStanković AleksandraĐurić TamaraŽivković MajaRistić P.Anđelković Z.Šumarac-Dumanović MirjanaAlavantić D.The peroxisome proliferator-activated receptor gamma (PPARγ) is a gene candidate for the onset of type 2 diabetes mellitus (T2DM). We investigated the association of the PPARγ Pro12Ala gene with the onset of T2DM for the first time in the Serbian population. The study population consisted of 197 controls and 163 T2DM patients. The 12Ala allele tended to be more frequent in the group of T2DM patients (0.11) compared to the control subjects (0.09). The results from this study indicate that the PPARγ2 12Ala allele presents a non-significant risk factor for T2DM development in the Serbian population.http://www.doiserbia.nb.rs/img/doi/0354-4664/2010/0354-46641002263S.pdfPPARγ2Pro12Ala polymorphismtype 2 diabetes mellitusinsulin |
| spellingShingle | Šoškić Sanja Stanković Aleksandra Đurić Tamara Živković Maja Ristić P. Anđelković Z. Šumarac-Dumanović Mirjana Alavantić D. Pro12Ala gene polymorphism in the peroxisome proliferator-activated receptor gamma as a risk factor for the onset of type 2 diabetes mellitus in the Serbian population Archives of Biological Sciences PPARγ2 Pro12Ala polymorphism type 2 diabetes mellitus insulin |
| title | Pro12Ala gene polymorphism in the peroxisome proliferator-activated receptor gamma as a risk factor for the onset of type 2 diabetes mellitus in the Serbian population |
| title_full | Pro12Ala gene polymorphism in the peroxisome proliferator-activated receptor gamma as a risk factor for the onset of type 2 diabetes mellitus in the Serbian population |
| title_fullStr | Pro12Ala gene polymorphism in the peroxisome proliferator-activated receptor gamma as a risk factor for the onset of type 2 diabetes mellitus in the Serbian population |
| title_full_unstemmed | Pro12Ala gene polymorphism in the peroxisome proliferator-activated receptor gamma as a risk factor for the onset of type 2 diabetes mellitus in the Serbian population |
| title_short | Pro12Ala gene polymorphism in the peroxisome proliferator-activated receptor gamma as a risk factor for the onset of type 2 diabetes mellitus in the Serbian population |
| title_sort | pro12ala gene polymorphism in the peroxisome proliferator activated receptor gamma as a risk factor for the onset of type 2 diabetes mellitus in the serbian population |
| topic | PPARγ2 Pro12Ala polymorphism type 2 diabetes mellitus insulin |
| url | http://www.doiserbia.nb.rs/img/doi/0354-4664/2010/0354-46641002263S.pdf |
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